Post-Translational Modifications in NETosis and NETs-Mediated Diseases

Untangling “NETosis” from NETs

(2019) Shida Yousefi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Histone Deacetylation Inhibitors as Therapy Concept in Sepsis

(2019) Andreas von Knethen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment

(2019) Rocio G Urdinguio et al.   NUCLEIC ACIDS RESEARCH

The Neutrophil’s Role During Health and Disease

(2019) Pei Xiong Liew et al.   PHYSIOLOGICAL REVIEWS

Histone Deacetylase Inhibitors Dose-Dependently Switch Neutrophil Death from NETosis to Apoptosis

(2019) Hussein J. Hamam et al.   Biomolecules

Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

(2018) Gabriel Sollberger et al.   DEVELOPMENTAL CELL

Role of Peptidylarginine Deiminase 4 in Neutrophil Extracellular Trap Formation and Host Defense duringKlebsiella pneumoniae–Induced Pneumonia-Derived Sepsis

(2018) Theodora A. M. Claushuis et al.   JOURNAL OF IMMUNOLOGY

Relative antibacterial functions of complement and NETs: NETs trap and complement effectively kills bacteria

(2018) Louiza Azzouz et al.   MOLECULAR IMMUNOLOGY

Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer

(2018) Charlotte Thålin et al.   PLoS One

Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone

(2018) Cristiane Naffah de Souza et al.   Frontiers in Immunology

ApoNETosis: discovery of a novel form of neutrophil death with concomitant apoptosis and NETosis

(2018) Dhia Azzouz et al.   Cell Death & Disease

Citrullinated Histone H3: Early Biomarker of Neutrophil Extracellular Traps in Septic Liver Damage

(2018) Kozo Nomura et al.   JOURNAL OF SURGICAL RESEARCH

Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology

(2017) Eva Sahakian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma

(2017) Li R. Kong et al.   Molecular Oncology

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

Lipopolysaccharide-induced neutrophil extracellular trap formation in canine neutrophils is dependent on histone H3 citrullination by peptidylarginine deiminase

(2017) Ronald H.L. Li et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Neutrophil extracellular trap formation upon exposure of hydrophobic materials to human whole blood causes thrombogenic reactions

(2017) Claudia Sperling et al.   Biomaterials Science

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Neutrophils and Immunity: From Bactericidal Action to Being Conquered

(2017) Tie-Shan Teng et al.   Journal of Immunology Research

Transcriptional firing helps to drive NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis

(2017) Meraj A. Khan et al.   Scientific Reports

Epigenetic regulation of the formyl peptide receptor 2 gene

(2016) Felice Simiele et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Human Brain Chemokine and Cytokine Expression in Sepsis: A Report of Three Cases

(2016) Jordan Warford et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver

(2016) Braedon McDonald et al.   GASTROENTEROLOGY

Granulopoiesis and granules of human neutrophils

(2016) Jack B. Cowland et al.   IMMUNOLOGICAL REVIEWS

Histone deacetylase inhibition is cytotoxic to oligodendrocyte precursor cells in vitro and in vivo

(2016) Toros A. Dincman et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity

(2016) Andrew Hollands et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alteration of histone H3 lysine 9 dimethylation in peripheral white blood cells of septic patients with trauma and cancer

(2016) Linghui Jiang et al.   Molecular Medicine Reports

NETosing Neutrophils Activate Complement Both on Their Own NETs and Bacteria via Alternative and Non-alternative Pathways

(2016) Joshua Yuen et al.   Frontiers in Immunology

Priming of neutrophils toward NETosis promotes tumor growth

(2016) Mélanie Demers et al.   OncoImmunology

Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury

(2016) Shuai Liu et al.   Scientific Reports

Protein Arginine Methylation and Citrullination in Epigenetic Regulation

(2015) Jakob Fuhrmann et al.   ACS Chemical Biology

Neutrophils: important contributors to tumor progression and metastasis

(2015) Agnieszka Swierczak et al.   CANCER AND METASTASIS REVIEWS

FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma

(2015) H.-Z. Lee et al.   CLINICAL CANCER RESEARCH

Panobinostat: First Global Approval

(2015) Karly P. Garnock-Jones   DRUGS

Histone deacetylase inhibitor restores surfactant protein-C expression in alveolar-epithelial type II cells and attenuates bleomycin-induced pulmonary fibrosisin vivo

(2015) Chiharu Ota et al.   EXPERIMENTAL LUNG RESEARCH

Imaging the dynamic platelet-neutrophil response in sterile liver injury and repair in mice

(2015) Ingrid Slaba et al.   HEPATOLOGY

Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cellsviachromatin remodelling

(2015) Giedre Valiuliene et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SK3 channel and mitochondrial ROS mediate NADPH oxidase-independent NETosis induced by calcium influx

(2015) David Nobuhiro Douda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Acetylation Modifiers in the Pathogenesis of Alzheimer’s Disease

(2015) Xi Lu et al.   Frontiers in Cellular Neuroscience

Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lprmice

(2014) Jason S Knight et al.   ANNALS OF THE RHEUMATIC DISEASES

Epigenetic and molecular mechanisms underlying the antileukemic activity of the histone deacetylase inhibitor belinostat in human acute promyelocytic leukemia cells

(2014) Jurate Savickiene et al.   ANTI-CANCER DRUGS

Neutrophil Extracellular Traps: Mechanisms of formation and role in health and disease

(2014) N. V. Vorobjeva et al.   BIOCHEMISTRY-MOSCOW

Acetylated histones contribute to the immunostimulatory potential of neutrophil extracellular traps in systemic lupus erythematosus

(2014) E. Pieterse et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Nemonoxacin: First Global Approval

(2014) Raewyn M. Poole   DRUGS

Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity

(2014) Nishant Dwivedi et al.   FASEB JOURNAL

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells

(2014) Fengdong Cheng et al.   MOLECULAR IMMUNOLOGY

Regulated necrosis: the expanding network of non-apoptotic cell death pathways

(2014) Tom Vanden Berghe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Efficient Neutrophil Extracellular Trap Induction Requires Mobilization of Both Intracellular and Extracellular Calcium Pools and Is Modulated by Cyclosporine A

(2014) Anurag Kumar Gupta et al.   PLoS One

A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis

(2014) Kathleen D. Metzler et al.   Cell Reports

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Belinostat-induced apoptosis and growth inhibition in pancreatic cancer cells involve activation of TAK1-AMPK signaling axis

(2013) Bing Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Valproic Acid Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

(2013) Mu-huo Ji et al.   INFLAMMATION

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Transmigration: Emergence of an Adhesive Cascade within Venular Walls

(2013) Mathieu-Benoit Voisin et al.   Journal of Innate Immunity

Utility of a Histone Deacetylase Inhibitor (PXD101) for Thyroid Cancer Treatment

(2013) Shu-Fu Lin et al.   PLoS One

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

(2013) Bassem Mohammed et al.   Nutrients

NET balancing: a problem in inflammatory lung diseases

(2013) Olivia Z. Cheng et al.   Frontiers in Immunology

Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release

(2013) Indira Neeli et al.   Frontiers in Immunology

Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes

(2012) Emilie Lukášová et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synergistic effect of panobinostat and bortezomib on chemoresistant acute myelogenous leukemia cells via AKT and NF-κB pathways

(2012) Xue-Jie Jiang et al.   CANCER LETTERS

Curcumin mediated epigenetic modulation inhibits TREM-1 expression in response to lipopolysaccharide

(2012) Zhihong Yuan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

The acute respiratory distress syndrome

(2012) Michael A. Matthay et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies

(2012) Chih Liu et al.   ARTHRITIS RESEARCH & THERAPY

Phase II study of the histone deacetylase inhibitor belinostat (PXD101) for the treatment of myelodysplastic syndrome (MDS)

(2011) Amanda Cashen et al.   ANNALS OF HEMATOLOGY

SUMO1 Negatively Regulates Reactive Oxygen Species Production From NADPH Oxidases

(2011) Deepesh Pandey et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Medicinal Chemistry of Sirtuin Inhibitors

(2011) L. Chen   CURRENT MEDICINAL CHEMISTRY

Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes

(2011) Patrick M Lombardi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Belinostat: clinical applications in solid tumors and lymphoma

(2011) L Rhoda Molife et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo

(2011) E. Rajakumara et al.   GENES & DEVELOPMENT

Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFκB-p300 Cross-talk in Favor of p53-p300 in Breast Cancer

(2011) Gouri Sankar Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase Inhibitor LAQ824 Augments Inflammatory Responses in Macrophages through Transcriptional Regulation of IL-10

(2011) Hongwei Wang et al.   JOURNAL OF IMMUNOLOGY

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

HDA6 Directly Interacts with DNA Methyltransferase MET1 and Maintains Transposable Element Silencing in Arabidopsis

(2011) X. Liu et al.   PLANT PHYSIOLOGY

Regulation of Neutrophil Survival/Apoptosis by Mcl-1

(2011) Eric Milot et al.   TheScientificWorldJOURNAL

Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle

(2010) Nima Alamdari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

(2010) J. Pillay et al.   BLOOD

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle: Establishment of a Vascular System Similar to That in Native Islets

(2010) G. Christoffersson et al.   DIABETES

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

(2010) Venizelos Papayannopoulos et al.   JOURNAL OF CELL BIOLOGY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Mechanism of Rapid Nuclear Neutrophil Extracellular Trap Formation in Response to Staphylococcus aureus

(2010) F. H. Pilsczek et al.   JOURNAL OF IMMUNOLOGY

Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils

(2010) Hannu Kankaanranta et al.   Journal of Inflammation-London

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Histone Deacetylase Inhibitors Attenuate Acute Lung Injury During Cecal Ligation and Puncture-Induced Polymicrobial Sepsis

(2010) Li Zhang et al.   WORLD JOURNAL OF SURGERY

Restoration of NET formation by gene therapy in CGD controls aspergillosis

(2009) M. Bianchi et al.   BLOOD

Fetal calf serum contains heat-stable nucleases that degrade neutrophil extracellular traps

(2009) M. von Kockritz-Blickwede et al.   BLOOD

Development of the pan-DAC inhibitor panobinostat (LBH589): Successes and challenges

(2009) Peter Atadja   CANCER LETTERS

Genome-wide Mapping of HATs and HDACs Reveals Distinct Functions in Active and Inactive Genes

(2009) Zhibin Wang et al.   CELL

Induction of Bim limits cytokine-mediated prolonged survival of neutrophils

(2009) N Andina et al.   CELL DEATH AND DIFFERENTIATION

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Histone deacetylase inhibitors: Potential in cancer therapy

(2009) P.A. Marks et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Functional Connection between Deimination and Deacetylation of Histones

(2009) H. Denis et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Linking DNA methylation and histone modification: patterns and paradigms

(2009) Howard Cedar et al.   NATURE REVIEWS GENETICS

Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing

(2009) Celia J. Webby et al.   SCIENCE

Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation

(2008) M. von Kockritz-Blickwede et al.   BLOOD

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors

(2008) N. L. Steele et al.   CLINICAL CANCER RESEARCH

Neutrophil apoptosis and the resolution of infection

(2008) Adam D. Kennedy et al.   IMMUNOLOGIC RESEARCH

Specificity of the Chromodomain Y Chromosome Family of Chromodomains for Lysine-methylated ARK(S/T) Motifs

(2008) Wolfgang Fischle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic interplay between histone modifications and DNA methylation in gene silencing

(2008) T VAISSIERE et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Systemic Lupus Erythematosus

(2008) Anisur Rahman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophils in cystic fibrosis

(2008) D G Downey et al.   THORAX

Apoptosis: controlled demolition at the cellular level

(2007) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY