Siglecs in Brain Function and Neurological Disorders

Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing

(2019) Satoshi Uchiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of CD33 as a genetic risk factor for Alzheimer’s disease

(2019) Steven Estus et al.   ACTA NEUROPATHOLOGICA

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains

(2019) John V. Pluvinage et al.   NATURE

The female reproductive tract contains multiple innate sialic acid-binding immunoglobulin-like lectins (Siglecs) that facilitate sperm survival

(2019) Eillen Tecle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

Microglial Lectins in Health and Neurological Diseases

(2018) Jian Jing Siew et al.   Frontiers in Molecular Neuroscience

Advances in the diagnosis, immunopathogenesis and therapies of IgM-anti-MAG antibody-mediated neuropathies

(2018) Marinos C. Dalakas   Therapeutic Advances in Neurological Disorders

Keeping it trim: roles of neuraminidases in CNS function

(2018) Alexey V. Pshezhetsky et al.   GLYCOCONJUGATE JOURNAL

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(2018) Michal A. Stanczak et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution of the exclusively human pathogen Neisseria gonorrhoeae : Human-specific engagement of immunoregulatory Siglecs

(2018) Corinna S. Landig et al.   Evolutionary Applications

Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes

(2017) Hiroyuki Konishi et al.   GLIA

The Alzheimer's disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool

(2017) Shoib S. Siddiqui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

(2017) Gitanjali Dharmadhikari et al.   Scientific Reports

Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina

(2016) Marcus Karlstetter et al.   EMBO Molecular Medicine

Sialoadhesin promotes neuroinflammation-related disease progression in two mouse models of CLN disease

(2016) Janos Groh et al.   GLIA

Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E

(2016) Shoib Siddiqui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Siglec-H protects from virus-triggered severe systemic autoimmunity

(2016) Heike Schmitt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neurological Aspects of Human Glycosylation Disorders

(2015) Hudson H. Freeze et al.   Annual Review of Neuroscience

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

(2015) Douglas G. Walker et al.   NEUROBIOLOGY OF AGING

Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

(2015) Shaun Spence et al.   Science Translational Medicine

Effects of Postinfarct Myelin-Associated Glycoprotein Antibody Treatment on Motor Recovery and Motor Map Plasticity in Squirrel Monkeys

(2015) Scott Barbay et al.   STROKE

Siglec receptors impact mammalian lifespan by modulating oxidative stress

(2015) Flavio Schwarz et al.   eLife

MAG, myelin and overcoming growth inhibition in the CNS

(2015) Lisa McKerracher et al.   Frontiers in Molecular Neuroscience

Siglec functions of microglia

(2014) B. Linnartz-Gerlach et al.   GLYCOBIOLOGY

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

(2014) T. Raj et al.   HUMAN MOLECULAR GENETICS

Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)

(2014) Barry M. Bradford et al.   IMMUNOLOGY

Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model

(2014) Sarah J. McMillan et al.   IMMUNOLOGY LETTERS

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins

(2014) B. Linnartz-Gerlach et al.   NEUROSCIENCE

Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration

(2014) Ronald L. Schnaar et al.   PHYSIOLOGICAL REVIEWS

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1

(2014) Guo-Yun Chen et al.   eLife

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b  2-integrin-dependent signaling

(2013) S. J. McMillan et al.   BLOOD

Siglec-h on activated microglia for recognition and engulfment of glioma cells

(2013) Jens Kopatz et al.   GLIA

Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

(2013) Yusuke Kameda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

Microglial CD33-Related Siglec-E Inhibits Neurotoxicity by Preventing the Phagocytosis-Associated Oxidative Burst

(2013) J. Claude et al.   JOURNAL OF NEUROSCIENCE

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Siglecs as sensors of self in innate and adaptive immune responses

(2012) James C. Paulson et al.   Annals of the New York Academy of Sciences

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-  secretion from monocytes/macrophages through the DAP12-Syk pathway

(2012) R. Takamiya et al.   GLYCOBIOLOGY

Siglec-15 Protein Regulates Formation of Functional Osteoclasts in Concert with DNAX-activating Protein of 12 kDa (DAP12)

(2012) Norihiro Ishida-Kitagawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of Siglec-11 and Siglec-16 Genes in Hominins

(2012) Xiaoxia Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Regulation of B Cell Functions by the Sialic Acid-Binding Receptors Siglec-G and CD22

(2012) Julia Jellusova et al.   Frontiers in Immunology

The participation of sialic acids in microglia–neuron interactions

(2011) Przemyslaw Wielgat et al.   CELLULAR IMMUNOLOGY

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

(2011) A. B. Perez-Oliva et al.   GLYCOBIOLOGY

SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas

(2011) Nivedita Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Pathogenesis and Treatment of Anti-MAG Neuropathy

(2010) Marinos C. Dalakas   Current Treatment Options in Neurology

Alleviation of Neurotoxicity by Microglial Human Siglec-11

(2010) Y. Wang et al.   JOURNAL OF NEUROSCIENCE

Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production

(2009) C. R. Boyd et al.   JOURNAL OF IMMUNOLOGY

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SIGLEC16encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpartSIGLEC11and has functional and non-functional alleles in humans

(2008) Huan Cao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY