Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

(2015) G. F. Weber et al.   SCIENCE

Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation

(2014) D. F. McAuley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Early Management of Severe Sepsis

(2014) Paul E. Marik   CHEST

IL-10 and Macrophages Orchestrate Gut Homeostasis

(2014) Alberto Mantovani et al.   IMMUNITY

Siglec-7 is an inhibitory receptor on human mast cells and basophils

(2014) Sa'ar Mizrahi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation

(2014) Norihito Kawasaki et al.   JOURNAL OF IMMUNOLOGY

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

(2014) Daniela Schmid et al.   MOLECULAR THERAPY

Simvastatin in the Acute Respiratory Distress Syndrome

(2014) Daniel F. McAuley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Effects of Human Mesenchymal Stem Cells inEx VivoHuman Lungs Injured with Live Bacteria

(2013) Jae W. Lee et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Enhanced Antitumor Activity of the Photosensitizer meso-Tetra(N-methyl-4-pyridyl) Porphine Tetra Tosylate through Encapsulation in Antibody-Targeted Chitosan/Alginate Nanoparticles

(2013) Sharif M. Abdelghany et al.   BIOMACROMOLECULES

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b  2-integrin-dependent signaling

(2013) S. J. McMillan et al.   BLOOD

TRAIL receptor agonist conatumumab with modified FOLFOX6 plus bevacizumab for first-line treatment of metastatic colorectal cancer

(2013) Charles S. Fuchs et al.   CANCER

Biomarkers in sepsis

(2013) Mervyn Singer   CURRENT OPINION IN PULMONARY MEDICINE

Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies

(2013) Brian D. Harms et al.   METHODS

Models and mechanisms of acute lung injury caused by direct insults

(2012) Lucy Kathleen Reiss et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Colonic Epithelial Cells Express Specific Ligands for Mucosal Macrophage Immunosuppressive Receptors Siglec-7 and -9

(2012) K. Miyazaki et al.   JOURNAL OF IMMUNOLOGY

Antigen Delivery to Macrophages Using Liposomal Nanoparticles Targeting Sialoadhesin/CD169

(2012) Weihsu C. Chen et al.   PLoS One

Disparate roles of marrow- and parenchymal cell-derived TLR4 signaling in murine LPS-induced systemic inflammation

(2012) Justin E. Juskewitch et al.   Scientific Reports

Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapy

(2011) Camilla Jandus et al.   BIOCHEMICAL PHARMACOLOGY

Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery

(2011) Francois Fay et al.   BIOMATERIALS

Targeting B lymphoma with nanoparticles bearing glycan ligands of CD22

(2011) Weihsu C. Chen et al.   LEUKEMIA & LYMPHOMA

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells

(2011) Emily Hams et al.   SHOCK

PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid

(2010) Lucia Bondioli et al.   BIOMATERIALS

In vivo targeting of B-cell lymphoma with glycan ligands of CD22

(2010) W. C. Chen et al.   BLOOD

Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma

(2010) J D Veltman et al.   BRITISH JOURNAL OF CANCER

Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution

(2010) G. Tosi et al.   JOURNAL OF CONTROLLED RELEASE

Histone Deacetylase Inhibitors Attenuate Acute Lung Injury During Cecal Ligation and Puncture-Induced Polymicrobial Sepsis

(2010) Li Zhang et al.   WORLD JOURNAL OF SURGERY

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Development of animal models for the acute respiratory distress syndrome

(2009) J. A. Bastarache et al.   Disease Models & Mechanisms

Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production

(2009) C. R. Boyd et al.   JOURNAL OF IMMUNOLOGY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung

(2009) J. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglecs as targets for therapy in immune-cell-mediated disease

(2009) Mary K. O’Reilly et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Animal models of acute lung injury

(2008) Gustavo Matute-Bello et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs

(2008) Munetoshi Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antibody Targeting of Camptothecin-Loaded PLGA Nanoparticles to Tumor Cells

(2008) Paul A. McCarron et al.   BIOCONJUGATE CHEMISTRY