Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b  2-integrin-dependent signaling

(2013) S. J. McMillan et al.   BLOOD

Macrophage Regulation of Tumor Responses to Anticancer Therapies

(2013) Michele De Palma et al.   CANCER CELL

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates

(2013) Vered Padler-Karavani et al.   FASEB JOURNAL

Binding of a Sialic Acid-recognizing Lectin Siglec-9 Modulates Adhesion Dynamics of Cancer Cells via Calpain-mediated Protein Degradation

(2013) Ilhamjan Sabit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of β-Catenin and Subsequent Cell Growth

(2013) Shuhei Tanida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Modulation of neutrophil granulocytes in the tumor microenvironment: Mechanisms and consequences for tumor progression

(2013) Claudia A. Dumitru et al.   SEMINARS IN CANCER BIOLOGY

CD33-related siglecs as potential modulators of inflammatory responses

(2012) Paul R. Crocker et al.   Annals of the New York Academy of Sciences

Abstract 3919: Novel model to study NFkB driven resistance to endocrine treatment in breast cancer

(2012) Leen Sas et al.   CANCER RESEARCH

Regulatory Circuits Mediated by Lectin-Glycan Interactions in Autoimmunity and Cancer

(2012) Gabriel A. Rabinovich et al.   IMMUNITY

Colonic Epithelial Cells Express Specific Ligands for Mucosal Macrophage Immunosuppressive Receptors Siglec-7 and -9

(2012) K. Miyazaki et al.   JOURNAL OF IMMUNOLOGY

Engagement of Siglec-7 Receptor Induces a Pro-Inflammatory Response Selectively in Monocytes

(2012) Stefania Varchetta et al.   PLoS One

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Transiently Entrapped Circulating Tumor Cells Interact with Neutrophils to Facilitate Lung Metastasis Development

(2010) S. J. Huh et al.   CANCER RESEARCH

A Novel Function of Siglec-9 A391C Polymorphism on T Cell Receptor Signaling

(2010) Kyung Ah Cheong et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Sialylation of 3-Methylcholanthrene-Induced Fibrosarcoma Determines Antitumor Immune Responses during Immunoediting

(2010) M. Cohen et al.   JOURNAL OF IMMUNOLOGY

Selectins promote tumor metastasis

(2010) Heinz Läubli et al.   SEMINARS IN CANCER BIOLOGY

Basic and Clinical Immunology of Siglecs

(2009) Stephan von Gunten et al.   Annals of the New York Academy of Sciences

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors

(2009) B. S. Bochner   CLINICAL AND EXPERIMENTAL ALLERGY

Group BStreptococcussuppression of phagocyte functions by protein-mediated engagement of human Siglec-5

(2009) Aaron F. Carlin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of Non-small Cell Lung Cancer

(2009) Ann G. Schwartz et al.   Journal of Thoracic Oncology

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Macrophage polarization in tumour progression

(2008) Antonio Sica et al.   SEMINARS IN CANCER BIOLOGY