Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing

Platelets Mediate Host Defense againstStaphylococcus aureusthrough Direct Bactericidal Activity and by Enhancing Macrophage Activities

(2016) Ramadan A. Ali et al.   JOURNAL OF IMMUNOLOGY

α-2,3-Sialyltransferase Expression Level Impacts the Kinetics of Lipooligosaccharide Sialylation, Complement Resistance, and the Ability of Neisseria gonorrhoeae to Colonize the Murine Genital Tract

(2015) Lisa A. Lewis et al.   mBio

Platelets and Infections – Complex Interactions with Bacteria

(2015) Hind Hamzeh-Cognasse et al.   Frontiers in Immunology

The interplay between Siglecs and sialylated pathogens

(2014) Y.-C. Chang et al.   GLYCOBIOLOGY

Human platelets express Toll-like receptor 3 and respond to poly I:C

(2014) Antonio-Santos Anabel et al.   HUMAN IMMUNOLOGY

A novel conditional platelet depletion mouse model reveals the importance of platelets in protection againstStaphylococcus aureusbacteremia

(2014) L. M. Wuescher et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelets: at the nexus of antimicrobial defence

(2014) Michael R. Yeaman   NATURE REVIEWS MICROBIOLOGY

Role of Siglec-7 in Apoptosis in Human Platelets

(2014) Kim Anh Nguyen et al.   PLoS One

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Considerations for a phase-III trial to evaluate a group B Streptococcus polysaccharide-protein conjugate vaccine in pregnant women for the prevention of early- and late-onset invasive disease in young-infants

(2013) Shabir A. Madhi et al.   VACCINE

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

(2012) Karen M Edmond et al.   LANCET

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

(2011) Bjoern F. Kraemer et al.   PLoS Pathogens

Bacterial–platelet interactions: virulence meets host defense

(2010) Michael R Yeaman   Future Microbiology

Effects of Sequential Campylobacter jejuni 81-176 Lipooligosaccharide Core Truncations on Biofilm Formation, Stress Survival, and Pathogenesis

(2010) M. Naito et al.   JOURNAL OF BACTERIOLOGY

Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response

(2009) A. F. Carlin et al.   BLOOD

Platelet-Derived Transforming Growth Factor-  Down-Regulates NKG2D Thereby Inhibiting Natural Killer Cell Antitumor Reactivity

(2009) H.-G. Kopp et al.   CANCER RESEARCH

Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X1-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y1 and P2Y12 receptor activation

(2009) Caroline Skoglund et al.   THROMBOSIS AND HAEMOSTASIS

Invasive Group B Streptococcal Disease in Non-pregnant Adults

(2008) P. Sendi et al.   INFECTION

Neonatal group B streptococcal disease: Incidence, presentation, and mortality

(2008) Sudqi Hamada et al.   Journal of Maternal-Fetal & Neonatal Medicine