Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

(2014) R. C. Ferreira et al.   DIABETES

TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6

(2014) Dominika Nackiewicz et al.   DIABETOLOGIA

Siglec-7 is an inhibitory receptor on human mast cells and basophils

(2014) Sa'ar Mizrahi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group BStreptococcus

(2014) Syed Raza Ali et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes

(2014) Amin Ardestani et al.   NATURE MEDICINE

Inflammation in Obesity and Diabetes: Islet Dysfunction and Therapeutic Opportunity

(2013) Marc Y. Donath et al.   Cell Metabolism

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Obesity is associated with activated and insulin resistant immune cells

(2012) A. Viardot et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Evolution of Siglec-11 and Siglec-16 Genes in Hominins

(2012) Xiaoxia Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

PPAR-γ Activation Restores Pancreatic Islet SERCA2 Levels and Prevents β-Cell Dysfunction under Conditions of Hyperglycemic and Cytokine Stress

(2012) Tatsuyoshi Kono et al.   MOLECULAR ENDOCRINOLOGY

Specific inactivation of two immunomodulatory SIGLEC genes during human evolution

(2012) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Siglecs—A novel pharmacological strategy for immuno- and glycotherapy

(2011) Camilla Jandus et al.   BIOCHEMICAL PHARMACOLOGY

Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology

(2011) X. Wang et al.   GLYCOBIOLOGY

SIGLEC12, a Human-specific Segregating (Pseudo)gene, Encodes a Signaling Molecule Expressed in Prostate Carcinomas

(2011) Nivedita Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

(2010) Mohan R. Dasu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Relative Over-Reactivity of Human versus Chimpanzee Lymphocytes: Implications for the Human Diseases Associated with Immune Activation

(2010) P. C. Soto et al.   JOURNAL OF IMMUNOLOGY

Intestinal macrophages and response to microbial encroachment

(2010) P D Smith et al.   Mucosal Immunology

Complementary expression of SN1 and SAT2 in the islets of Langerhans suggests concerted action of glutamine transport in the regulation of insulin secretion

(2009) R. Gammelsaeter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia

(2009) E. Brunetta et al.   BLOOD

CXCL10 Impairs β Cell Function and Viability in Diabetes through TLR4 Signaling

(2009) Fabienne T. Schulthess et al.   Cell Metabolism

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia

(2008) Kankana Mukherjee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY