New Insights into the Crosstalk between NMDARs and Iron: Implications for Understanding Pathology of Neurological Diseases

Amyloid-beta peptide decreases expression and function of glutamate transporters in nervous system cells

(2017) Huichun Tong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

(2017) Hilmar Bading   JOURNAL OF EXPERIMENTAL MEDICINE

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

(2017) Sandro Altamura et al.   JOURNAL OF ALZHEIMERS DISEASE

Iron Deficiency Impairs Developing Hippocampal Neuron Gene Expression, Energy Metabolism, and Dendrite Complexity

(2016) Thomas W. Bastian et al.   DEVELOPMENTAL NEUROSCIENCE

Role of iron in neurodegenerative diseases

(2016) Kai Li et al.   JOURNAL OF NEURAL TRANSMISSION

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

Brain Iron Metabolism Dysfunction in Parkinson’s Disease

(2016) Hong Jiang et al.   MOLECULAR NEUROBIOLOGY

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

(2016) Li-Na Lu et al.   MOLECULAR NEUROBIOLOGY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Iron overload-induced calcium signals modulate mitochondrial fragmentation in HT-22 hippocampal neuron cells

(2016) Dong Gil Lee et al.   TOXICOLOGY

Activation of ATP-sensitive potassium channels enhances DMT1-mediated iron uptake in SK-N-SH cells in vitro

(2016) Xixun Du et al.   Scientific Reports

Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1

(2016) Rachel S. White et al.   Molecular Brain

Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies

(2016) Francisco J. Carvajal et al.   NEURAL PLASTICITY

Parkinson’s Disease: The Mitochondria-Iron Link

(2016) Yorka Muñoz et al.   Parkinsons Disease

Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment

(2016) J. M. G. van Bergen et al.   Scientific Reports

Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons

(2015) Yan-Na Wu et al.   BRAIN RESEARCH

Ceruloplasmin is Involved in the Nigral Iron Accumulation of 6-OHDA-Lesioned Rats

(2015) Jun Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation

(2015) Yong Chen et al.   FEBS LETTERS

Ischemic stroke, inflammation, iron overload – Connection to a hepcidin

(2015) Julia Petrova et al.   International Journal of Stroke

Quantitative susceptibility mapping of the midbrain in Parkinson's disease

(2015) Guangwei Du et al.   MOVEMENT DISORDERS

Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy

(2015) Victor S. Van Laar et al.   NEUROBIOLOGY OF DISEASE

Is the 1254T>C polymorphism in the DMT1 gene associated with Parkinson’s disease?

(2015) Selva Moheb Saadat et al.   NEUROSCIENCE LETTERS

Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems

(2015) László Köles et al.   Purinergic Signalling

Effect of Dietary Iron Loading on Recognition Memory in Growing Rats

(2015) Murui Han et al.   PLoS One

Focusing Brain Therapeutic Interventions in Space and Time for Parkinson’s Disease

(2014) S. Little et al.   CURRENT BIOLOGY

NMDARs in neurological diseases: a potential therapeutic target

(2014) Janneth Gonzalez et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Molecular mechanisms of cognitive impairment in iron deficiency: Alterations in brain-derived neurotrophic factor and Insulin-like growth factor expression and function in the central nervous system

(2014) José A. Estrada et al.   NUTRITIONAL NEUROSCIENCE

Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling

(2014) Michael J. Courtney et al.   Frontiers in Cellular Neuroscience

Rotigotine protects against glutamate toxicity in primary dopaminergic cell culture

(2013) Sandra Oster et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of α-synuclein aggregation and the nuclear factor E2-related factor 2/heme oxygenase-1 pathway in iron-induced neurotoxicity

(2013) Qing He et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

(2013) Giulia Ambrosi et al.   JOURNAL OF NEURAL TRANSMISSION

Dexras1, a Small GTPase, Is Required for Glutamate-NMDA Neurotoxicity

(2013) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

PKA modulates iron trafficking in the striatum via small GTPase, Rhes

(2013) B.-R. Choi et al.   NEUROSCIENCE

DMT1 (IRE) expression in intestinal and erythroid cells is regulated by peripheral benzodiazepine receptor-associated protein 7

(2012) Yasumasa Okazaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration

(2012) Julia Schiemann et al.   NATURE NEUROSCIENCE

Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity

(2011) Pablo Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity

(2010) Ilaria Pelizzoni et al.   AGING CELL

Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent

(2010) Hong Jiang et al.   CELL RESEARCH

NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling

(2010) Surojit Paul et al.   JOURNAL OF NEUROCHEMISTRY

Ca2+ Influx through NMDA-Gated Channels Activates ATP-Sensitive K+ Currents through a Nitric Oxide-cGMP Pathway in Subthalamic Neurons

(2010) K.-Z. Shen et al.   JOURNAL OF NEUROSCIENCE

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Aβ generation

(2009) Wei Zheng et al.   FASEB JOURNAL

Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease

(2009) Ning Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Iron Is Essential for Neuron Development and Memory Function in Mouse Hippocampus

(2009) Erik S. Carlson et al.   JOURNAL OF NUTRITION

Nitric Oxide Activates ATP-Sensitive Potassium Channels in Mammalian Sensory Neurons: Action by Direct S-Nitrosylation

(2009) Takashi Kawano et al.   Molecular Pain

Memantine treatment decreases levels of secreted Alzheimer's amyloid precursor protein (APP) and amyloid beta (Aβ) peptide in the human neuroblastoma cells

(2009) Balmiki Ray et al.   NEUROSCIENCE LETTERS

Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training

(2009) Paola Haeger et al.   NEUROTOXICITY RESEARCH

Quantitative MR Phase-corrected Imaging to Investigate Increased Brain Iron Deposition of Patients with Alzheimer Disease

(2009) Wen-zhen Zhu et al.   RADIOLOGY

Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons

(2008) Jixu Yu et al.   BRAIN RESEARCH

Oligodendrocytes and myelination: The role of iron

(2008) Bozho Todorich et al.   GLIA

Single Particle Characterization of Iron-induced Pore-forming α-Synuclein Oligomers

(2008) Marcus Kostka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

(2008) Shuzhen Zhang et al.   NEUROBIOLOGY OF AGING

Basic Research on Dopamine in Parkinson’s Disease and the Discovery of the Nigrostriatal Dopamine Pathway: The View of an Eyewitness

(2008) Oleh Hornykiewicz   Neurodegenerative Diseases

Increased vulnerability to rotenone-induced neurotoxicity in ceruloplasmin-deficient mice

(2008) Kazuma Kaneko et al.   NEUROSCIENCE LETTERS

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons

(2007) Francesco Errico et al.   MOLECULAR AND CELLULAR NEUROSCIENCE