Lower Expression of Ndfip1 Is Associated With Alzheimer Disease Pathogenesis Through Decreasing DMT1 Degradation and Increasing Iron Influx

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease

(2018) Ya-Shuo Zhao et al.   ANTIOXIDANTS & REDOX SIGNALING

Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: Implications for age-related neurodegenerative diseases

(2018) Pamela Maher   FREE RADICAL BIOLOGY AND MEDICINE

Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

(2018) Paul A. Adlard et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary lipophilic iron alters amyloidogenesis and microglial morphology in Alzheimer's disease knock-in APP mice

(2018) Douglas G. Peters et al.   Metallomics

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese

(2018) Natascha A. Wolff  et al.   Scientific Reports

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Transport of Non-Transferrin Bound Iron to the Brain: Implications for Alzheimer’s Disease

(2017) Ajai K. Tripathi et al.   JOURNAL OF ALZHEIMERS DISEASE

Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain

(2017) Cheng-Wu Zhang et al.   NEUROMOLECULAR MEDICINE

Protective effects and mechanisms of Ndfipl on SH-SY5Y cell apoptosis in an in vitro Parkinson’s disease model

(2016) L.F. Xing et al.   GENETICS AND MOLECULAR RESEARCH

Activation of ATP-sensitive potassium channels enhances DMT1-mediated iron uptake in SK-N-SH cells in vitro

(2016) Xixun Du et al.   Scientific Reports

Protective effects of Ndfip1 on MPP+-induced apoptosis in MES23.5 cells and its underlying mechanisms

(2015) Kai Liu et al.   EXPERIMENTAL NEUROLOGY

Nedd4 Family Interacting Protein 1 (Ndfip1) Is Required for Ubiquitination and Nuclear Trafficking of BRCA1-associated ATM Activator 1 (BRAT1) during the DNA Damage Response

(2015) Ley-Hian Low et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ndfip1 attenuated 6-OHDA–induced iron accumulation via regulating the degradation of DMT1

(2015) Wenting Jia et al.   NEUROBIOLOGY OF AGING

A Novel Model for Brain Iron Uptake: Introducing the Concept of Regulation

(2014) Ian A Simpson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased Ndfip1 in the Substantia Nigra of Parkinsonian Brains Is Associated with Elevated Iron Levels

(2014) Jason Howitt et al.   PLoS One

Nuclear trafficking of Pten after brain injury leads to neuron survival not death

(2013) Choo-Peng Goh et al.   EXPERIMENTAL NEUROLOGY

Review: Iron metabolism and the role of iron in neurodegenerative disorders

(2013) M. Hadzhieva et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

(2012) Michael D. Garrick et al.   BIOMETALS

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake

(2012) Ling Xie et al.   NEUROCHEMISTRY INTERNATIONAL

Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain

(2012) Chuang Guo et al.   NEUROCHEMISTRY INTERNATIONAL

Iron(II) Binding to Amyloid-β, the Alzheimer’s Peptide

(2011) Fatima Bousejra-ElGarah et al.   INORGANIC CHEMISTRY

Huperzine A Activates Wnt/β-Catenin Signaling and Enhances the Nonamyloidogenic Pathway in an Alzheimer Transgenic Mouse Model

(2011) Chun-Yan Wang et al.   NEUROPSYCHOPHARMACOLOGY

Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis

(2010) N. J. Foot et al.   BLOOD

Up-regulation of divalent metal transporter 1 in 6-hydroxydopamine intoxication is IRE/IRP dependent

(2010) Hong Jiang et al.   CELL RESEARCH

Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

(2010) Beinan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divalent metal transporter 1 is involved in amyloid precursor protein processing and Aβ generation

(2009) Wei Zheng et al.   FASEB JOURNAL

Rg1 protects the MPP+-treated MES23.5 cells via attenuating DMT1 up-regulation and cellular iron uptake

(2009) Huamin Xu et al.   NEUROPHARMACOLOGY

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

(2009) J. Howitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

(2008) N. J. Foot et al.   BLOOD

Up-regulation of divalent metal transporter 1 is involved in 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in MES23.5 cells

(2008) Shuzhen Zhang et al.   NEUROBIOLOGY OF AGING

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA