Article
Chemistry, Medicinal
Li-Cheng Zhou, Ying-Fan Liang, Yi Huang, Gui-Xiang Yang, Lu-Lu Zheng, Jia-Min Sun, Yang Li, Fu-Li Zhu, He-Wen Qian, Rui Wang, Lei Ma
Summary: The study developed diosgenin-indole compounds with potential neuroprotective effects against H2O2, 6-OHDA, and Aβ damages. Compound 5b showed promising results with strong binding affinity to Aβ(1-42), favorable BBB permeation, and absorption abilities. In vivo experiments demonstrated that 5b attenuated memory and learning impairments of Aβ-injected mice, suggesting its potential as a dual-functional neuroprotective agent against AD.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Shagufta Parveen, Aneeqa Batool, Nusrat Shafiq, Maryam Rashid, Ayesha Sultan, Gezahign Fentahun Wondmie, Yousef A. Bin Jardan, Simone Brogi, Mohammed Bourhia
Summary: In this study, compounds with antioxidant activity were screened from pomegranate peels for the treatment of Alzheimer's disease. The inhibitory effect of estrogen on Alzheimer's disease and its role in protecting the brain were investigated. Computational calculations and experiments identified hesperidin as a potential candidate for drug discovery.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Neurosciences
Chen-Yang He, Ding-Yuan Tian, Si-Han Chen, Wang-Sheng Jin, Yuan Cheng, Jia-Yan Xin, Wei-Wei Li, Gui-Hua Zeng, Cheng-Rong Tan, Jie-Ming Jian, Dong-Yu Fan, Jun-Rong Ren, Yu-Hui Liu, Yan-Jiang Wang, Fan Zeng
Summary: This study found that the levels of p75ECD-NAbs were increased in AD patients and negatively correlated with the levels of p75ECD. Transgenic AD mice immunized with p75ECD showed more severe AD pathology and worse cognitive functions compared to the control groups.
NEUROSCIENCE BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Yi Wang, Kaiyue Wang, Junyuan Yan, Qian Zhou, Xiaoying Wang
Summary: Alzheimer's disease is an incurable type of dementia in the elderly, and our understanding of its etiology and pathogenesis is limited. However, several hypotheses related to risk factors have been proposed, and plant-derived dietary polyphenols have been shown to have protective effects against neurodegenerative diseases. This review summarizes the regulatory effects of these polyphenols on AD-related molecular mechanisms and discusses the issue of bioavailability and potential improvements, aiming to encourage further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Anthony Kin Yip Liew, Chuin Hau Teo, Tomoko Soga
Summary: This article summarizes the evidence for environmental enrichment (EE) as a neuroprotective strategy and discusses the potential molecular pathways that explain its effects from a biochemical perspective. It also explores the differences in early and late life EE exposure and its potential application in humans.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Genetics & Heredity
Yuxin Deng, Hui Song, Yan Xiao, Yi Zhao, Liangzao Chu, Jiuyang Ding, Xiangchun Shen, Xiaolan Qi
Summary: This study explores the effects of A beta and senescence on astrocytes at the transcriptome level and identifies core genes associated with extracellular matrix and focal adhesion. In addition, competing endogenous RNA networks are constructed to uncover the regulatory mechanism of A beta and senescence on astrocytes. This work provides new insights and research perspectives into the pathogenesis of AD.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Clinical Neurology
Lisi Flores-Aguilar, Helene Hall, Chiara Orciani, Morgan K. Foret, Olivia Kovecses, Adriana Ducatenzeiler, A. Claudio Cuello
Summary: The degeneration of the locus coeruleus aggravates the neuroinflammatory process, cognitive impairments, cholinergic deficits, and neurotrophin deregulation at the earliest stages of the human-like brain amyloidosis.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Matthew K. Taylor, Debra K. Sullivan, Jill K. Morris, Eric D. Vidoni, Robyn A. Honea, Jonathan D. Mahnken, Jeffrey M. Burns
Summary: The study aimed to investigate the relationship between high glycemic diet and changes in brain amyloid over a year. Results showed that higher intake of high glycemic diet, sugar, and total carbohydrate were associated with more amyloid accumulation in certain regions of the brain among cognitively normal older adults, especially those with elevated amyloid levels. Further research is needed to determine if there is a causal link between high glycemic diet and brain amyloid accumulation.
FRONTIERS IN NUTRITION
(2021)
Article
Plant Sciences
Antonis Ververis, Kristia Ioannou, Sotiris Kyriakou, Niki Violaki, Mihalis I. Panayiotidis, Michael Plioukas, Kyproula Christodoulou
Summary: Alzheimer's disease (AD) is a prevalent neurodegenerative condition in aging populations with no effective therapy available. Recent research has focused on reducing the toxic amyloid beta aggregates and oxidative stress, which are closely associated with AD. Medicinal plants, such as Sideritis scardica (SS), have shown neuroprotective effects against AD. We investigated the antioxidant and neuroprotective potential of eight solvent fractions derived from SS and found that most fractions were rich in phenolics and flavonoids, with significant antioxidant activity. Four SS extracts were able to partially restore cell viability in A beta(25-35)-treated neuroblastoma cells, indicating their neuroprotective properties. These extracts contained neuroprotective substances like apigenin, myricetin-3-galactoside, and ellagic acid. The findings suggest that specific SS mixtures have potential for the development of herbal drugs and functional food products to alleviate AD symptoms.
Article
Chemistry, Physical
Asra Nasir Khan, Kundlik Gadhave, Mohammad Furkan, Prateek Kumar, Mohammad Khursheed Siddiqi, Rajanish Giri, Rizwan Hasan Khan
Summary: Thionamide antibiotics prothionamide and ethionamide could effectively inhibit amyloid formation of human insulin and A beta 42, and protect neuroblastoma cells from the toxic effects of amyloids. These drugs exert their anti-amyloid potency by stabilizing proteins in their native state and also possess antioxidant properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Isabelle Baussanne, Olga Firstova, Andreea Botezatu Dediu, Camille Larosa, Bianca Furdui, Ioana Ottilia Ghinea, Aline Thomas, Sabine Chierici, Rodica Dinica, Martine Demeunynck
Summary: A small library of molecules combining indolizine and N-alkyl pyridinium was synthesized and evaluated for Alzheimer's disease treatment. The new compounds were classified in three series based on the number of methylene residues linking the two heterocycles, and their activities against AD targets were assessed in vitro.
BIOORGANIC CHEMISTRY
(2021)
Article
Clinical Neurology
Nanet Willumsen, Teresa Poole, Jennifer M. Nicholas, Nick C. Fox, Natalie S. Ryan, Tammaryn Lashley
Summary: This study found significant heterogeneity in A beta pathology among familial Alzheimer's disease cases, with different mutations potentially leading to varying patterns of A beta deposition. Carriage of the APOE4 allele may be associated with increased disease duration but not age at onset.
Review
Biochemistry & Molecular Biology
Arian Kola, Dorota Dudek, Daniela Valensin
Summary: Polyphenols are plant-derived compounds with potent antioxidant properties that have been studied for their benefits in preventing and treating various diseases, including cancer and neurodegenerative diseases. Their relationship with Alzheimer's disease has been extensively researched, focusing on their antioxidant properties and metal chelating features.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
A. Rai, O. A. Ojiakor, R. J. Rylett
Summary: The ApoE4 allele is a genetic risk factor for Alzheimer's disease, increasing the risk of developing the disease by up to three-fold. This study shows that ApoE4 influences multiple genetic and molecular pathways including neural cell maintenance, insulin signaling, amyloid processing and clearance, and synaptic plasticity. Additionally, ApoE4-expressing mice fed a high-fat diet exhibit metabolic disturbances that are associated with an increased risk of Alzheimer's disease in humans.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Behavioral Sciences
Milena Cioana, Bernadeta Michalski, Margaret Fahnestock
Review
Neurosciences
Chiara Nicolini, Margaret Fahnestock, Martin J. Gibala, Aimee J. Nelson
Summary: Exercise is a promising and cost-effective intervention for successful aging and neurorehabilitation by reducing atrophy within the motor system and inducing neuroplasticity. Understanding the neurophysiological and molecular mechanisms underlying exercise-induced brain changes is crucial for developing more effective, personalized exercise protocols.
Article
Clinical Neurology
Minesh Kapadia, M. Firoz Mian, Donglai Ma, Craig P. Hutton, Amber Azam, Klotilda Narkaj, Chuanhai Cao, Breanna Brown, Bernadeta Michalski, David Morgan, Paul Forsythe, Iva B. Zovkic, Margaret Fahnestock, Boris Sakic
Summary: Immunosuppression in 3xTg-AD mice prevented certain AD pathology features in males and maintained AD-like phenotype in females. This suggests a potential key role of autoimmunity in the pathogenesis of AD.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Devon S. Placides, Kevin Ratnasamy, Chao Ma, Jerry B. Hunt, Huimin Liang, John Ivan T. Calahatian, Camilla Michalski, Margaret Fahnestock, Laura J. Blair, April L. Darling, Jeremy D. Baker, Sarah N. Fontaine, Chad A. Dickey, Joshua J. Gamsby, Kevin R. Nash, Erin Abner, Maj-Linda B. Selenica, Daniel C. Lee
Summary: The study reveals an interaction between polyamine metabolism, behavioral impairment, and tau pathology. Dysregulation of polyamine metabolism is associated with tau deposition and cognitive/affective behavioral impairments, with different effects observed for higher-order polyamines and acetylpolyamines on tau seeding and oligomerization. The tau-induced polyamine stress response affects disease progression and may offer potential targets for treating tauopathies, including Alzheimer's disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Chemistry, Medicinal
Maria de los Angeles Robinson-Agramonte, Bernadeta Michalski, Lazaro Gomez Fernandez, Belkis Vidal-Martinez, Hector Vera Cuesta, Carlos Maragoto Rizo, Margaret Fahnestock
Summary: The study aimed to investigate the impact of NIBS therapy on serum levels of BDNF and IGF-1 in individuals with autism spectrum disorder. The results showed a significant reduction in scores on clinical behavioral scales in patients treated with NIBS.
DRUG DEVELOPMENT RESEARCH
(2021)
Review
Neurosciences
Kevin Morris, Mohammad Nami, Joe F. Bolanos, Maria A. Lobo, Melody Sadri-Naini, John Fiallos, Gilberto E. Sanchez, Teshia Bustos, Nikita Chintam, Marco Amaya, Susanne E. Strand, Alero Mayuku-Dore, Indira Sakibova, Grace Maria Nicole Biso, Alejandro DeFilippis, Daniela Bravo, Nevzat Tarhan, Carsten Claussen, Alejandro Mercado, Serge Braun, Louis Yuge, Shigeo Okabe, Farhad Taghizadeh-Hesary, Konstantin Kotliar, Christina Sadowsky, P. Sarat Chandra, Manjari Tripathi, Vasileios Katsaros, Brian Mehling, Maryam Noroozian, Kazem Abbasioun, Abbas Amirjamshidi, Gholam-Ali Hossein-Zadeh, Faridedin Naraghi, Mojtaba Barzegar, Ali A. Asadi-Pooya, Sajad Sahab-Negah, Saeid Sadeghian, Margaret Fahnestock, Nesrin Dilbaz, Namath Hussain, Zoltan Mari, Robert W. Thatcher, Daniel Sipple, Kuldip Sidhu, Deepak Chopra, Francesco Costa, Giannantonio Spena, Ted Berger, Deborah Zelinsky, Christopher J. Wheeler, J. Wesson Ashford, Reinhard Schulte, M. A. Nezami, Harry Kloor, Aaron Filler, Dawn S. Eliashiv, Dipen Sinha, Antonio A. F. DeSalles, Venkatraman Sadanand, Sergey Suchkov, Ken Green, Barish Metin, Robert Hariri, Jason Cormier, Vicky Yamamoto, Babak Kateb
Summary: Neurological disorders have a significant impact on the global economy, and require global collaboration and resource sharing to reduce disease burden, promote neurotechnology and innovation development, and reduce costs.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Cell Biology
Erika Kropf, Margaret Fahnestock
Summary: Nerve growth factor (NGF) and its precursor, proNGF, play critical roles in neuronal survival and cognitive function. Dysregulation of proNGF may contribute to age-related memory loss and Alzheimer's disease. Increased reactive oxygen and nitrogen species (ROS/RNS) in the brain may impair proNGF transport and signalling, leading to vulnerability of the basal forebrain in AD. Antioxidant treatments may help restore proNGF signalling and reduce neurodegeneration and cognitive deficits in the basal forebrain.
Article
Biochemistry & Molecular Biology
Mona Abdollahi, Margaret Fahnestock
Summary: Nurr1 and BDNF play important roles in cognition, with Nurr1 regulating BDNF in different brain areas. However, Nurr1 does not regulate BDNF in cortical neurons. Treatment with Nurr1 agonist AQ and membrane depolarization increased Nurr1 and BDNF expression in cortical neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Maria de los Angeles Robinson-Agramonte, Bernadeta Michalski, Belkis Vidal-Martinez, Leyanis Ramos Hernandez, Mabel Whilby Santiesteban, Margaret Fahnestock
Summary: Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) are involved in the pathogenesis and treatment of autism spectrum disorder (ASD), with increased serum levels of IGF-1 and decreased serum levels of proBDNF in ASD subjects, particularly in medicated individuals.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Natalia Pienkowska, Margaret Fahnestock, Crystal Mahadeo, Izabela Zaborniak, Pawel Chmielarz, Grzegorz Bartosz, Izabela Sadowska-Bartosz
Summary: This study found that overexpression of tau protein leads to changes in the redox status of human neuroblastoma SH-SY5Y cells. Tau-overexpressing cells showed elevated levels of reactive oxygen species (ROS) and glutathione, indicating their heightened sensitivity to oxidative stress. The use of nitroxide-containing nanoparticles mitigated tau-protein-induced oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sama Jaberi, Margaret Fahnestock, Baoji Xu
Summary: Brain-derived neurotrophic factor (BDNF) is a key molecule in promoting neuronal health and function, and its disruption is associated with neurological and cognitive disorders. Pathological insults in Alzheimer's disease include the formation of Aβ plaques and tau tangles, as well as immune dysfunction and oxidative stress. Physical exercise enhances BDNF expression, improving learning and memory, and alleviating Alzheimer's disease pathology.
Article
Health Care Sciences & Services
Karishma R. Ramdeo, Margaret Fahnestock, Martin Gibala, Ponnambalam Ravi Selvaganapathy, Justin Lee, Aimee Jennifer Nelson
Summary: This study aims to investigate whether interval training enhances synaptic plasticity in individuals with MCI and its correlation with cognitive function, serum brain-derived neurotrophic factor, and osteocalcin. The results of this research will provide a new avenue for understanding the impact of exercise on neural plasticity in individuals with MCI.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Neurosciences
Erika Kropf, Arman Shekari, Sama Jaberi, Anish Puri, Chengbiao Wu, Margaret Fahnestock
Summary: The study found that age-induced nitrative stress decreases proNGF transport via TrkA while increasing proNGF transport via p75(NTR). These transport deficits are associated with decreased survival signaling, increased apoptotic signaling, and neurodegeneration.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Maram Khaled, Jocelyn Kuber, Mary Ferber, Praveen Sritharan, Yarden Levy, Suzanna Becker, Margaret Fahnestock, Meridith Griffin, Kim Madden, Harsha Shanthanna, Maura Marcucci
Summary: This study aims to investigate the association between chronic postsurgical pain (CPSP) and postoperative cognitive dysfunction (POCD), as well as the role of patient satisfaction, pain medications, patient preoccupation/optimism, and coping strategies in determining the effect of pain on cognition. Additionally, the study will explore the hypothesis of neurogenesis interference as an underlying mechanism.
CANADIAN JOURNAL OF PAIN-REVUE CANADIENNE DE LA DOULEUR
(2022)
Meeting Abstract
Immunology
Donglai Ma, Wei Song, Bernadeta Michalski, Boris Sakic, Margaret Fahnestock
JOURNAL OF IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)