Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease

The Heme Oxygenase/Biliverdin Reductase Pathway in Drug Research and Development

(2012) C. Mancuso et al.   CURRENT DRUG METABOLISM

Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

(2011) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain

(2011) D. Allan Butterfield et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory

(2011) A. Suzuki et al.   JOURNAL OF NEUROSCIENCE

Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders

(2011) D. Allan Butterfield et al.   PHARMACOLOGICAL RESEARCH

Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice

(2010) Tomoko Kurata et al.   BRAIN RESEARCH

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: Implications for Aβ accumulation in AD brain

(2010) Joshua B. Owen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Roles of nitric oxide, carbon monoxide, and hydrogen sulfide in the regulation of the hypothalamic-pituitary-adrenal axis

(2010) Cesare Mancuso et al.   JOURNAL OF NEUROCHEMISTRY

How does PKMζ maintain long-term memory?

(2010) Todd C. Sacktor   NATURE REVIEWS NEUROSCIENCE

Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe

(2010) H. H. Feldman et al.   NEUROLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: A novel mechanism of action

(2010) Eugenio Barone et al.   PHARMACOLOGICAL RESEARCH

The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXα reductase and human biliverdin-IXβ reductase

(2009) Edward M. Franklin et al.   FEBS Journal

Characterization of the S-denitrosylating activity of bilirubin

(2009) Eugenio Barone et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Therapeutic potential of statins in Alzheimer's disease

(2009) Nagaendran Kandiah et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Pharmacological Preconditioning With Simvastatin Protects Liver From Ischemia-Reperfusion Injury by Heme Oxygenase-1 Induction

(2009) I-Rue Lai et al.   TRANSPLANTATION

Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin

(2009) Jaime Kapitulnik et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation ofHO-1gene expression by haematin

(2008) Cicerone Tudor et al.   BIOCHEMICAL JOURNAL

Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease

(2008) Giovanna Cenini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bilirubin as an endogenous modulator of neurotrophin redox signaling

(2008) Cesare Mancuso et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling

(2008) N. Lerner-Marmarosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative Stress, Aging, and Central Nervous System Disease in the Canine Model of Human Brain Aging

(2008) Elizabeth Head et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease

(2006) Wycliffe O. Opii et al.   NEUROBIOLOGY OF AGING