Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer’s Disease: A Translational Study of Neuropathological and Inflammatory Markers

The Canine (Dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches

(2017) Carl W. Cotman et al.   JOURNAL OF ALZHEIMERS DISEASE

Inflammatory Aspects of Alzheimer Disease and Other Neurodegenerative Disorders

(2017) Claudia Schwab et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β Peptide and Oligomers in the Brain and Cerebrospinal Fluid of Aged Canines

(2017) Elizabeth Head et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment

(2015) Tomas Smolek et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Detection and Quantification of β-Amyloid, Pyroglutamyl Aβ, and Tau in Aged Canines

(2015) Franziska Schmidt et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A  Pharmacodynamic Responses in Mice, Dogs, and Humans

(2015) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Cognitive Function, Progression of Age-related Behavioral Changes, Biomarkers, and Survival in Dogs More Than 8 Years Old

(2015) T. Schütt et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Amyloid-� Immunotherapy Reduces Amyloid Plaques and Astroglial Reaction in Aged Domestic Dogs

(2014) Maria Neus Bosch et al.   Neurodegenerative Diseases

Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models

(2013) Jeffrey L. Frost et al.   AMERICAN JOURNAL OF PATHOLOGY

An Observational Study with Long-Term Follow-Up of Canine Cognitive Dysfunction: Clinical Characteristics, Survival, and Risk Factors

(2013) R. Fast et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease

(2012) Suzanne E. Hickman et al.   CNS & Neurological Disorders-Drug Targets

Dogs with Cognitive Dysfunction Syndrome: A Natural Model of Alzheimer’s Disease

(2012) Maria Neus Bosch et al.   Current Alzheimer Research

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Animal systems in the development of treatments for Alzheimer's disease: challenges, methods, and implications

(2012) Jonathan J. Sabbagh et al.   NEUROBIOLOGY OF AGING

Cognitive Dysfunction Syndrome

(2012) Gary M. Landsberg et al.   VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE

Characterization of AβpN3 deposition in the brains of dogs of various ages and other animal species

(2011) James K. Chambers et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

Therapeutic Interventions Targeting Beta Amyloid Pathogenesis in an Aging Dog Model

(2011) Sarah B. Martin et al.   Current Neuropharmacology

Histopathological and Immunohistochemical Comparison of the Brain of Human Patients with Alzheimer’s Disease and the Brain of Aged Dogs with Cognitive Dysfunction

(2011) C.-H. Yu et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Recent rodent models for Alzheimer’s disease: clinical implications and basic research

(2011) Nady Braidy et al.   JOURNAL OF NEURAL TRANSMISSION

Circulating cytokine concentrations in dogs with different degrees of myxomatous mitral valve disease

(2011) Nora E. Zois et al.   VETERINARY JOURNAL

Plasma β-Amyloid and Cognitive Decline

(2010) Stephanie A. Cosentino et al.   ARCHIVES OF NEUROLOGY

Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines

(2010) Viorela Pop et al.   NEUROBIOLOGY OF AGING

Review: Sporadic cerebral amyloid angiopathy

(2010) J. Attems et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing

(2010) L. Sarasa et al.   NEUROSCIENCE

The canine cognitive dysfunction rating scale (CCDR): A data-driven and ecologically relevant assessment tool

(2010) Hannah E. Salvin et al.   VETERINARY JOURNAL

Microglial Activation in Alzheimers Disease

(2009) Johannes Schlachetzki et al.   Current Alzheimer Research

β-amyloid cortical deposits are accompanied by the loss of serotonergic neurons in the dog

(2009) Vanessa Bernedo et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Magnetic resonance imaging of cerebral involutional changes in dogs as markers of aging: An innovative tool adapted from a human visual rating scale

(2009) Marco Pugliese et al.   VETERINARY JOURNAL

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Dogs with canine counterpart of Alzheimer's disease lose noradrenergic neurons

(2008) Daniel Insua et al.   NEUROBIOLOGY OF AGING

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: Relevance to Alzheimer's disease

(2006) Wycliffe O. Opii et al.   NEUROBIOLOGY OF AGING

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment

(2006) Christina T. Siwak-Tapp et al.   NEUROBIOLOGY OF AGING