Review
Chemistry, Medicinal
Pooja Ravaria, Priyanka Saxena, B. S. Shruti Laksmi, Vikas Ranjan, Syed Wasfi Fatma Abidi, Priyanka Saha, Siva Ramamoorthy, Faraz Ahmad, Sandeep Singh Rana
Summary: Rosmarinic acid (RA), a natural phenolic compound found in culinary herbs, has been established as an effective ameliorative agent against various disorders, particularly neurodegenerative diseases. The neuroprotective effects of RA stem from its multimodal actions on cellular and molecular pathways, and it has shown potential in treating diseases such as Alzheimer's, Huntington's, Parkinson's, and ALS. This review discusses the pharmacokinetics of RA, its neuroprotective mechanisms, and its potential in CNS disorders.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Silvia Zampar, Oliver Wirths
Summary: The relationship between extracellular amyloid-beta deposits and intracellular accumulation of hyperphosphorylated tau in Alzheimer's Disease (AD) remains not fully understood. Studies have shown that A beta deposits trigger tau phosphorylation and accumulation, but the impact of different A beta variants on tau pathology is still debated. Crossbreeding studies on transgenic mouse models suggest that A beta(4-42) peptides may have partial negative effects on motor performance and spatial memory in aged mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jennifer S. Rabin, Emma Nichols, Renaud La Joie, Kaitlin B. Casaletto, Priya Palta, Kristen Dams-O'Connor, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie A. Schneider, Judy Pa, Adam M. Brickman
Summary: Accumulating data suggests that cerebrovascular disease contributes to the pathophysiology and progression of Alzheimer's disease. Cerebral amyloid angiopathy, characterized by the build-up of beta-amyloid in blood vessel walls, commonly co-occurs with Alzheimer's disease in the aging brain and increases the risk of dementia. This study found that cerebral amyloid angiopathy independently or interactively influences tau deposition and cognitive decline, and tau mediates the association between cerebral amyloid angiopathy and cognitive decline.
Article
Cell Biology
Sha Sha, Xiao-Na Xing, Tao Wang, Ying Li, Rong-Wei Zhang, Xue-Li Shen, Yun-Peng Cao, Le Qu
Summary: This study demonstrates that the p(A beta 3-10)10-MT vaccine can effectively reduce A beta oligomer levels and plaque deposition, decrease tau protein variants, protect synaptic function, reduce neuron loss, and improve memory impairment in a mouse model of Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Article
Clinical Neurology
Sourin Bhuniya, Manish Goyal, Nilotpal Chowdhury, Priyadarshini Mishra
Summary: Patients with obstructive sleep apnea have higher serum levels of amyloid-beta and tau proteins, which are associated with nocturnal oxygen saturation and changes in sleep architecture. Monitoring for signs of cognitive impairment and treating obstructive sleep apnea may reverse neurodegenerative changes and prevent cognitive impairment.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Seul-Ki Yoo, Jong-Min Kim, Uk Lee, Jin-Yong Kang, Seon-Kyeong Park, Hye-Ju Han, Hyo-Won Park, Hyun-Jin Kim, Chul-Woo Kim, Mahn-Jo Kim, Ho-Jin Heo
Summary: This study confirmed the beneficial effects of immature persimmon ethanolic extract on neuronal cytotoxicity induced by amyloid beta in mice, by protecting the cerebral cholinergic system and antioxidant system, as well as regulating mitochondrial function and tau signaling. Gallic acid, ellagic acid, and quercetin were identified as the physiological compounds in the extract.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Review
Cell Biology
Martina Gabrielli, Francesca Tozzi, Claudia Verderio, Nicola Origlia
Summary: Alzheimer's disease (AD) is characterized by synaptic failure, with extracellular vesicles (EVs) released by brain cells playing a crucial role in the early stages. This review examines the contribution of EVs from different brain cells to neuronal alterations and proposes a model for EV-mediated propagation of synaptic dysfunction in early AD. Understanding the interaction between EVs and neurons may lead to new therapeutic approaches for AD.
Article
Multidisciplinary Sciences
Shinwoo Kang, Jinho Kim, Keun-A Chang
Summary: The novel 6xTg-AD mouse model, developed by crossing 5xFAD mice with mice expressing mutant tau protein, exhibits faster onset of AD-related pathologies compared to their parental models, showing promise as an advanced tool for studying AD and developing therapeutic interventions.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Samar O. El-Ganainy, Omar A. Soliman, Aya A. Ghazy, Maram Allam, Aya I. Elbahnasi, Amira M. Mansour, Mennatallah A. Gowayed
Summary: Oxytocin has neuroprotective potential in Alzheimer's disease, restoring cognition and suppressing beta-amyloid, Tau accumulation, and neuronal death. Combined treatment with galantamine and oxytocin shows better biochemical and histopathological profiles.
NEUROCHEMICAL RESEARCH
(2022)
Article
Immunology
Erin E. Sundermann, Mark W. Bondi, Laura M. Campbell, Ben Gouaux, Raeanne C. Moore, Virawudh Soontornniyomkij, David J. Moore
Summary: This study aimed to distinguish aMCI from HAND in PWH using a neuropsychological method, finding a higher prevalence of high aMCI risk in the HAND group, with beta-amyloid pathology being associated with high aMCI risk, while phospho-Tau pathology did not differ by aMCI classification.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Neurosciences
Leslie C. Norins
Summary: Substantial evidence supports the clinical testing of FDA-approved drugs for repurposing to treat Alzheimer's disease, including drug mechanisms of action, in vivo testing, and epidemiological data. Investigating already-approved compounds can be faster and more cost-effective than un-approved compounds in the drug pipeline. With the increasing prevalence of AD due to longer life expectancy, the lack of an effective drug for treatment is a pressing public health concern.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Chang Youn Lee, In Soo Ryu, Jin-Hyeob Ryu, Hyun-Jeong Cho
Summary: Alzheimer's disease is a progressive neurodegenerative disorder, with miRNAs playing a crucial role in its pathological processes. Limitations of current pharmaceutical therapies have led to research on miRNA-based next-generation therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Kaitlin B. Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M. Simone, Jennifer S. Rabin, Renaud La Joie, Adam M. Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie Schneider, Judy Pa
Summary: Females with Alzheimer's disease are more susceptible than males, and microglial activation plays an important mediating role in females but not males. This finding is crucial for understanding the pathogenesis of Alzheimer's disease and providing precision health care.
Article
Neurosciences
Hao-Lun Sun, Xiu-Qing Yao, Li Lei, Wang-Sheng Jin, Yu-Di Bai, Gui-Hua Zeng, An-Yu Shi, Jun Liang, Li Zhu, Yu-Hui Liu, Yan-Jiang Wang, Xian-Le Bu
Summary: This study found that renal failure is associated with abnormal AD biomarkers and cognitive decline, suggesting that renal function may be involved in the pathogenesis of AD.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Kevin A. Murray, Carolyn J. Hu, Sarah L. Griner, Hope Pan, Jeannette T. Bowler, Romany Abskharon, Gregory M. Rosenberg, Xinyi Cheng, Paul M. Seidler, David S. Eisenberg
Summary: Neurodegenerative diseases are characterized by the accumulation of aggregated proteins, and inhibiting the formation of these aggregates is a potential therapeutic strategy. Using de novo protein design, researchers have developed a library of mini-protein inhibitors that specifically target the amyloid structures of tau, Aβ, and α Syn. These inhibitors show promising results in preventing aggregation and rescuing motor deficits in animal models of PD and AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Veterinary Sciences
Hagar Hauser
Summary: Separation-related problems (SRPs) are common in companion dogs and clinicians should be able to diagnose and rule out physical diseases that may exhibit similar clinical signs or worsen SRP.
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Clara Wilson, Dana Ebbecke, Danielle Berger, Cynthia Otto
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Lisa Radosta
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Patrizia Piotti, Ludovica Pierantoni, Mariangela Albertini, Federica Pirrone
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Lena Provoost
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
M. Leanne Lilly, Carlo Siracusa
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Daniel S. Mills, Fergus M. Coutts, Kevin J. Mcpeake
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Marta Amat, Susana Le Brech, Xavier Manteca
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Sagi Denenberg, Karen L. Machin, Gary M. Landsberg
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Leticia M. S. Dantas, Niwako Ogata
Summary: The stress response has a significant impact on the central nervous system and other systems in the body, contributing to chronic mental and behavioral pathologies as well as increasing the risk for other chronic inflammatory and metabolic diseases. Psychiatric treatments play a role in alleviating fear, stress, and anxiety and improving the quality of life and lifespan for dogs and cats. The availability of safe psychoactive medications allows for effective treatment options in veterinary patients. Clinicians should have a good understanding of the role neurotransmitters and hormones play in emotional processing, cognition, and behavior, as well as the mechanism of action of drugs to ensure appropriate medication selection for each individual patient.
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Editorial Material
Veterinary Sciences
Carlo Siracusa
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Valarie V. Tynes
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Amy Learn, Debra Horwitz
Summary: Inappropriate elimination or behavioral periuria/perichezia is a commonly reported feline behavioral problem worldwide. Changes in behavior are often early signs of physical illness and can worsen existing behavioral issues. Determining the cause, whether medical or behavioral, is crucial before implementing appropriate treatments.
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Jonathan Bowen, Jaume Fatjo
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
Article
Veterinary Sciences
Maya Braem
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
(2024)
