Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

(2018) Rafeeq Mir et al.   BIOCHEMICAL JOURNAL

The impact of murine LRRK2 G2019S transgene overexpression on acute responses to inflammatory challenge

(2018) Darcy Litteljohn et al.   BRAIN BEHAVIOR AND IMMUNITY

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

(2018) Anetta Härtlova et al.   EMBO JOURNAL

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

(2018) Ga Ram Jeong et al.   Molecular Neurodegeneration

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

(2018) Jason Schapansky et al.   NEUROBIOLOGY OF DISEASE

Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response

(2018) Allen G Wu et al.   PEDIATRIC RESEARCH

Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease

(2018) Kwang Soo Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

(2018) Ken Y. Hui et al.   Science Translational Medicine

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice

(2018) Salvatore Novello et al.   NEUROBIOLOGY OF DISEASE

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

(2018) Eun-Jin Bae et al.   Nature Communications

The vermiform appendix impacts the risk of developing Parkinson’s disease

(2018) Bryan A. Killinger et al.   Science Translational Medicine

Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

(2017) Andrew B. West   EXPERIMENTAL NEUROLOGY

LRRK2 promotes the activation of NLRC4 inflammasome duringSalmonellaTyphimurium infection

(2017) Weiwei Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects

(2017) Julianna J. Tomlinson et al.   JOURNAL OF NEURAL TRANSMISSION

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Age-Dependent Dopaminergic Neurodegeneration and Impairment of the Autophagy-Lysosomal Pathway in LRRK -Deficient Mice

(2017) Emilie Giaime et al.   NEURON

Interleukin-10 Production by T and B Cells Is a Key Factor to Promote Systemic Salmonella enterica Serovar Typhimurium Infection in Mice

(2017) Geraldyne A. Salazar et al.   Frontiers in Immunology

Sex differences in LRRK2 G2019S and idiopathic Parkinson's Disease

(2017) Marta San Luciano et al.   Annals of Clinical and Translational Neurology

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo

(2016) B Shutinoski et al.   CELL DEATH AND DIFFERENTIATION

Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PREDIGT score

(2016) Michael G. Schlossmacher et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

G2019S-LRRK2 Expression Augments  -Synuclein Sequestration into Inclusions in Neurons

(2016) L. A. Volpicelli-Daley et al.   JOURNAL OF NEUROSCIENCE

DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study

(2016) Joanne Trinh et al.   LANCET NEUROLOGY

Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers

(2016) Nicolas Dzamko et al.   MOVEMENT DISORDERS

The Evolution of Genetics: Alzheimer’s and Parkinson’s Diseases

(2016) Andrew Singleton et al.   NEURON

Genetic Factors Are Not the Major Causes of Chronic Diseases

(2016) Stephen M. Rappaport   PLoS One

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

(2016) Vinicius M. Fava et al.   PLoS Neglected Tropical Diseases

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

LRRK2 Pathways Leading to Neurodegeneration

(2015) Mark R. Cookson   Current Neurology and Neuroscience Reports

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury

(2015) R. Boddu et al.   HUMAN MOLECULAR GENETICS

The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins

(2015) Mark S. Moehle et al.   HUMAN MOLECULAR GENETICS

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

(2015) João P. L. Daher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain

(2015) Erica L. Beatman et al.   JOURNAL OF VIROLOGY

LRRK2 and Nod2 promote lysozyme sorting in Paneth cells

(2015) Juliana D B Rocha et al.   NATURE IMMUNOLOGY

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

(2015) M. Yue et al.   NEUROBIOLOGY OF DISEASE

Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

(2015) Elpida Tsika et al.   NEUROBIOLOGY OF DISEASE

Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium

(2015) Karen Marder et al.   NEUROLOGY

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson’s disease

(2015) J. Schapansky et al.   NEUROSCIENCE

LRRK2 mutations in Parkinson disease; a sex effect or lack thereof? A meta-analysis

(2015) Ziv Gan-Or et al.   PARKINSONISM & RELATED DISORDERS

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

(2015) Reina N. Fuji et al.   Science Translational Medicine

The Salmonella effector protein SifA plays a dual role in virulence

(2015) Weidong Zhao et al.   Scientific Reports

Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease

(2015) Lorraine V. Kalia et al.   JAMA Neurology

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

(2014) Andrew B. West et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages

(2014) Martin Kuss et al.   JOURNAL OF NEUROCHEMISTRY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

(2014) Elpida Tsika et al.   NEUROBIOLOGY OF DISEASE

Heterogeneity of Leucine-Rich Repeat Kinase 2 Mutations: Genetics, Mechanisms and Therapeutic Implications

(2014) Iakov N. Rudenko et al.   Neurotherapeutics

LRRK2 mutations in Parkinson's disease: Confirmation of a gender effect in the Italian population

(2014) Roberto Cilia et al.   PARKINSONISM & RELATED DISORDERS

Abrogation of  -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

(2014) J. P. L. Daher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease Penetrance of Late-Onset Parkinsonism

(2014) Joanne Trinh et al.   JAMA Neurology

Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects

(2013) Madison T. Gray et al.   MOVEMENT DISORDERS

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis

(2013) Daniel Ness et al.   PLoS One

Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

(2013) Marco A. S. Baptista et al.   PLoS One

Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis

(2013) Lianne Gauvin et al.   Virology Journal

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Identical twins with Leucine rich repeat kinase type 2 mutations discordant for Parkinson's disease

(2012) Georgia Xiromerisiou et al.   MOVEMENT DISORDERS

Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

(2012) Nirmal Robinson et al.   NATURE IMMUNOLOGY

Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

(2011) Valerie Cullen et al.   ANNALS OF NEUROLOGY

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

(2011) Martin C. Herzig et al.   HUMAN MOLECULAR GENETICS

Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities

(2011) Philip J. Webber et al.   JOURNAL OF MOLECULAR BIOLOGY

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case–control study

(2011) Owen A Ross et al.   LANCET NEUROLOGY

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

Membrane Localization of LRRK2 Is Associated with Increased Formation of the Highly Active LRRK2 Dimer and Changes in Its Phosphorylation

(2010) Zdenek Berger et al.   BIOCHEMISTRY

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

(2010) Byoung Dae Lee et al.   NATURE MEDICINE

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

A comparative study of Lrrk2 function in primary neuronal cultures

(2010) Justus C. Dächsel et al.   PARKINSONISM & RELATED DISORDERS

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-24 protects againstSalmonella typhimuriuminfection by stimulating early neutrophil Th1 cytokine production, which in turn activates CD8+T cells

(2009) Yunfeng Ma et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

(2009) Hye Young Heo et al.   EXPERIMENTAL CELL RESEARCH

A Common Genetic Fingerprint in Leprosy and Crohn's Disease?

(2009) Erwin Schurr et al.   NEW ENGLAND JOURNAL OF MEDICINE

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

(2009) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY

Invited Article: Nervous system pathology in sporadic Parkinson disease

(2008) H. Braak et al.   NEUROLOGY