Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects
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Title
Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects
Authors
Keywords
Histology, Parkinson disease, Alzheimer disease, Synucleinopathy, Neuropathology, SNCA/α-synuclein, MAPT/tau, APP/Aβ, Genome, Susceptibility, Exposome, Inoculation, Infection
Journal
JOURNAL OF NEURAL TRANSMISSION
Volume 124, Issue 6, Pages 721-738
Publisher
Springer Nature
Online
2017-05-05
DOI
10.1007/s00702-017-1726-7
References
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Related references
Note: Only part of the references are listed.- The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases
- (2018) Nolwen L. Rey et al. NEUROBIOLOGY OF DISEASE
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- (2017) Raffaella Carletti et al. PARKINSONISM & RELATED DISORDERS
- Functional characterization of alpha-synuclein protein with antimicrobial activity
- (2016) Seong-Cheol Park et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- (2016) Timothy R. Sampson et al. CELL
- K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo
- (2016) B Shutinoski et al. CELL DEATH AND DIFFERENTIATION
- Modelling idiopathic Parkinson disease as a complex illness can inform incidence rate in healthy adults: the PREDIGT score
- (2016) Michael G. Schlossmacher et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- A critical role for alpha-synuclein in development and function of T lymphocytes
- (2016) Afshin Shameli et al. IMMUNOBIOLOGY
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- (2016) Matthew W. Granger et al. JOURNAL OF ALZHEIMERS DISEASE
- Microbes and Alzheimer’s Disease
- (2016) Ruth F. Itzhaki et al. JOURNAL OF ALZHEIMERS DISEASE
- α-Synuclein Fibrils Exhibit Gain of Toxic Function, Promoting Tau Aggregation and Inhibiting Microtubule Assembly
- (2016) Takayuki Oikawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders
- (2016) Brit Mollenhauer et al. JOURNAL OF NEUROCHEMISTRY
- Increased peripheral inflammation in asymptomatic leucine-rich repeat kinase 2 mutation carriers
- (2016) Nicolas Dzamko et al. MOVEMENT DISORDERS
- First-in-human assessment of PRX002, an anti-α-synuclein monoclonal antibody, in healthy volunteers
- (2016) Dale B. Schenk et al. MOVEMENT DISORDERS
- A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration
- (2016) Dominic M. Walsh et al. NATURE REVIEWS NEUROSCIENCE
- Dose-dependent progression of parkinsonism in manganese-exposed welders
- (2016) Brad A. Racette et al. NEUROLOGY
- Monitoring of 30 marker candidates in early Parkinson disease as progression markers
- (2016) Brit Mollenhauer et al. NEUROLOGY
- Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology
- (2016) K. Del Tredici et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Genetic Factors Are Not the Major Causes of Chronic Diseases
- (2016) Stephen M. Rappaport PLoS One
- Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
- (2016) Deepak Kumar Vijaya Kumar et al. Science Translational Medicine
- Prevalence of Submandibular Gland Synucleinopathy in Parkinson’s Disease, Dementia with Lewy Bodies and other Lewy Body Disorders
- (2016) Thomas G. Beach et al. Journal of Parkinsons Disease
- A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy
- (2016) Vinicius M. Fava et al. PLoS Neglected Tropical Diseases
- Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders
- (2016) Martin Ingelsson Frontiers in Neuroscience
- Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans
- (2016) Shu G. Chen et al. Scientific Reports
- Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease
- (2015) Joseph J. Locascio et al. BRAIN
- Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain
- (2015) Erica L. Beatman et al. JOURNAL OF VIROLOGY
- MDS research criteria for prodromal Parkinson's disease
- (2015) Daniela Berg et al. MOVEMENT DISORDERS
- Tau in physiology and pathology
- (2015) Yipeng Wang et al. NATURE REVIEWS NEUROSCIENCE
- Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology
- (2015) Nishant N. Vaikath et al. NEUROBIOLOGY OF DISEASE
- An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb
- (2015) Arkarup Banerjee et al. NEURON
- Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation
- (2014) Ianai Fishbein et al. BRAIN
- Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease
- (2014) Wenbin Xiao et al. IMMUNOBIOLOGY
- Gut microbiota are related to Parkinson's disease and clinical phenotype
- (2014) Filip Scheperjans et al. MOVEMENT DISORDERS
- A Test for Creutzfeldt–Jakob Disease Using Nasal Brushings
- (2014) Christina D. Orrú et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alpha-synuclein in the appendiceal mucosa of neurologically intact subjects
- (2013) Madison T. Gray et al. MOVEMENT DISORDERS
- CLARITY for mapping the nervous system
- (2013) Kwanghun Chung et al. NATURE METHODS
- Advances in the genetics of Parkinson disease
- (2013) Joanne Trinh et al. Nature Reviews Neurology
- Rasagiline Ameliorates Olfactory Deficits in an Alpha-Synuclein Mouse Model of Parkinson's Disease
- (2013) Géraldine H. Petit et al. PLoS One
- Leucine-Rich Repeat Kinase 2 (LRRK2)-Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis
- (2013) Daniel Ness et al. PLoS One
- Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease
- (2013) Shyra J. Gardai et al. PLoS One
- Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis
- (2013) Lianne Gauvin et al. Virology Journal
- Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau181, and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease
- (2013) Ju-Hee Kang JAMA Neurology
- Considerations Regarding the Etiology and Future Treatment of Autosomal Recessive Versus Idiopathic Parkinson Disease
- (2012) Tohru Kitada et al. Current Treatment Options in Neurology
- MutantGBA1Expression and Synucleinopathy Risk: First Insights from Cellular and Mouse Models
- (2012) S. Pablo Sardi et al. Neurodegenerative Diseases
- Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects
- (2012) Brit Mollenhauer et al. NEUROSCIENCE LETTERS
- Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing
- (2011) Valerie Cullen et al. ANNALS OF NEUROLOGY
- Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
- (2011) Mansoureh Hakimi et al. JOURNAL OF NEURAL TRANSMISSION
- The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
- (2011) Zhihua Liu et al. NATURE IMMUNOLOGY
- Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease
- (2010) Todd L. Edwards et al. ANNALS OF HUMAN GENETICS
- Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
- (2010) Alexis Elbaz et al. ANNALS OF NEUROLOGY
- Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes
- (2010) Yien-Ming Kuo et al. HUMAN MOLECULAR GENETICS
- LRRK2 Is Involved in the IFN- Response and Host Response to Pathogens
- (2010) A. Gardet et al. JOURNAL OF IMMUNOLOGY
- The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide
- (2010) Stephanie J. Soscia et al. PLoS One
- Olfactory epithelium amyloid-β and paired helical filament-tau pathology in Alzheimer disease
- (2009) Steven E. Arnold et al. ANNALS OF NEUROLOGY
- Lewy body pathology in fetal grafts
- (2009) Yaping Chu et al. Annals of the New York Academy of Sciences
- Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration
- (2009) H. Jang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Olfactory deficits in mice overexpressing human wildtype -synuclein
- (2008) Sheila M. Fleming et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Direct quantification of CSF α-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration
- (2008) Brit Mollenhauer et al. EXPERIMENTAL NEUROLOGY
- GATA transcription factors directly regulate the Parkinson's disease-linked gene -synuclein
- (2008) C. R. Scherzer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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