Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages

Selective Roles of MAPKs during the Macrophage Response to IFN- 

(2014) A. F. Valledor et al.   JOURNAL OF IMMUNOLOGY

Phosphoproteomic evaluation of pharmacological inhibition of leucine-rich repeat kinase 2 reveals significant off-target effects of LRRK-2-IN-1

(2013) Gregory C. Luerman et al.   JOURNAL OF NEUROCHEMISTRY

Canonical and Kinase Activity-Independent Mechanisms for Extracellular Signal-Regulated Kinase 5 (ERK5) Nuclear Translocation Require Dissociation of Hsp90 from the ERK5-Cdc37 Complex

(2013) T. Erazo et al.   MOLECULAR AND CELLULAR BIOLOGY

Insights into LRRK2 function and dysfunction from transgenic and knockout rodent models: Figure 1

(2012) Maximilian Sloan et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

(2012) Jinwei Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ERK5: Structure, regulation and function

(2012) Gopika N. Nithianandarajah-Jones et al.   CELLULAR SIGNALLING

The interferons and their receptors-distribution and regulation

(2012) Nicole A de Weerd et al.   IMMUNOLOGY AND CELL BIOLOGY

Parkinson’s disease and immune system: is the culprit LRRKing in the periphery?

(2012) Elisa Greggio et al.   Journal of Neuroinflammation

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

Modulation of Neuronal Survival Factor MEF2 by Kinases in Parkinson’s Disease

(2012) Yue Yin et al.   Frontiers in Physiology

Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons

(2011) Nigel Ramsden et al.   ACS Chemical Biology

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Genetic mouse models for understanding LRRK2 biology, pathology and pre-clinical application

(2011) Zhenyu Yue   PARKINSONISM & RELATED DISORDERS

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein

(2010) Qingkai Yang et al.   CANCER CELL

Multisite phosphorylation of Erk5 in mitosis

(2010) E. DIaz-RodrIguez et al.   JOURNAL OF CELL SCIENCE

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

(2009) R. Jeremy Nichols et al.   BIOCHEMICAL JOURNAL

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of pharmacological inhibitors of the MEK5/ERK5 pathway

(2008) Revati J. Tatake et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2

(2008) Jason P. Covy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS