Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease

Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia

(2018) Juan G. Zarruk et al.   EXPERIMENTAL NEUROLOGY

LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila

(2017) Paul C. Marcogliese et al.   HUMAN MOLECULAR GENETICS

Endoplasmic reticulum-resident Rab8A GTPase is involved in phagocytosis in the protozoan parasiteEntamoeba histolytica

(2016) Yuki Hanadate et al.   CELLULAR MICROBIOLOGY

A Missense LRRK2 Variant Is a Risk Factor for Excessive Inflammatory Responses in Leprosy

(2016) Vinicius M. Fava et al.   PLoS Neglected Tropical Diseases

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

(2016) Tomoki Kuwahara et al.   Scientific Reports

The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins

(2015) Mark S. Moehle et al.   HUMAN MOLECULAR GENETICS

An early endosome regulator, Rab5b, is an LRRK2 kinase substrate

(2015) Hye Jin Yun et al.   JOURNAL OF BIOCHEMISTRY

Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

(2014) Ian Martin et al.   CELL

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

(2014) J. Schapansky et al.   HUMAN MOLECULAR GENETICS

Differences in the Phagocytic Response of Microglia and Peripheral Macrophages after Spinal Cord Injury and Its Effects on Cell Death

(2014) A. D. Greenhalgh et al.   JOURNAL OF NEUROSCIENCE

Abrogation of  -synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

(2014) J. P. L. Daher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primary Culture of Mouse Dopaminergic Neurons

(2014) Florence Gaven et al.   Jove-Journal of Visualized Experiments

SCAR/WAVE-mediated processing of engulfed apoptotic corpses is essential for effective macrophage migration in Drosophila

(2013) I R Evans et al.   CELL DEATH AND DIFFERENTIATION

Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices

(2013) Sylvie Girard et al.   GLIA

Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

(2013) Kurt M. Lucin et al.   NEURON

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein

(2012) Daniel F Marker et al.   Journal of Neuroinflammation

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo

(2012) Carlos Barcia et al.   Scientific Reports

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation

(2011) Jonathan Thévenet et al.   PLoS One

Essential role for Abi1 in embryonic survival and WAVE2 complex integrity

(2011) P. M. Dubielecka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

A QUICK Screen for Lrrk2 Interaction Partners – Leucine-rich Repeat Kinase 2 is Involved in Actin Cytoskeleton Dynamics

(2010) Andrea Meixner et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure and control of the actin regulatory WAVE complex

(2010) Zhucheng Chen et al.   NATURE

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Leucine-rich repeat kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

(2009) K. Venderova et al.   HUMAN MOLECULAR GENETICS

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain

(2009) J. Doherty et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

(2009) L. Parisiadou et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein and Its A30P Mutant Affect Actin Cytoskeletal Structure and Dynamics

(2009) Vítor L. Sousa et al.   MOLECULAR BIOLOGY OF THE CELL

PINK1 gene knockdown leads to increased binding of parkin with actin filament

(2009) Kyung-Hee Kim et al.   NEUROSCIENCE LETTERS

Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review

(2009) L. Correia Guedes et al.   PARKINSONISM & RELATED DISORDERS

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

(2008) Yuzuru Imai et al.   EMBO JOURNAL

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

WAVE2 is regulated by multiple phosphorylation events within its VCA domain

(2008) Shirin M. Pocha et al.   CELL MOTILITY AND THE CYTOSKELETON