Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: A therapeutic target to reduce intestinal inflammation

Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)

(2019) Meige Sun et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

The emergence of melatonin in oncology: Focus on colorectal cancer

(2019) Emilio Gil‐Martín et al.   MEDICINAL RESEARCH REVIEWS

Melatonin Synthesis and Function: Evolutionary History in Animals and Plants

(2019) Dake Zhao et al.   Frontiers in Endocrinology

Autophagy: The Last Defense against Cellular Nutritional Stress

(2018) Long He et al.   Advances in Nutrition

Circadian Clock Proteins and Melatonin Receptors in Neurons and Glia of the Sapajus apella Cerebellum

(2018) Leila M. Guissoni Campos et al.   Frontiers in Physiology

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

(2018) Ning Ma et al.   Frontiers in Immunology

Dietary Amino Acids and the Gut-Microbiome-Immune Axis: Physiological Metabolism and Therapeutic Prospects

(2018) Ning Ma et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Antimicrobial peptides: Promising alternatives in the post feeding antibiotic era

(2018) Jiajun Wang et al.   MEDICINAL RESEARCH REVIEWS

NF-κB signalling is involved in immune-modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock

(2017) S. M. O'Keeffe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Metabolism of melatonin in the skin: Why is it important?

(2017) Andrzej T. Slominski et al.   EXPERIMENTAL DERMATOLOGY

Melatonin alleviates weanling stress in mice: Involvement of intestinal microbiota

(2017) Wenkai Ren et al.   JOURNAL OF PINEAL RESEARCH

Human transporters, PEPT1/2, facilitate melatonin transportation into mitochondria of cancer cells: An implication of the therapeutic potential

(2017) Xiaokui Huo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents obesity through modulation of gut microbiota in mice

(2017) Pengfei Xu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin's role as a co-adjuvant treatment in colonic diseases: A review

(2017) Eduardo Esteban-Zubero et al.   LIFE SCIENCES

Basic understanding and therapeutic approaches to target toll-like receptors in cancerous microenvironment and metastasis

(2017) Mojtaba Khajeh Alizadeh Attar et al.   MEDICINAL RESEARCH REVIEWS

Understanding the Molecular Mechanisms of the Interplay Between Herbal Medicines and Gut Microbiota

(2017) Jun Xu et al.   MEDICINAL RESEARCH REVIEWS

NO and HNO donors, nitrones, and nitroxides: Past, present, and future

(2017) Catarina Oliveira et al.   MEDICINAL RESEARCH REVIEWS

Taxon- and Site-Specific Melatonin Catabolism

(2017) Rüdiger Hardeland   MOLECULES

The resilience of the intestinal microbiota influences health and disease

(2017) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders

(2017) Fiona Auld et al.   SLEEP MEDICINE REVIEWS

Daily corticosterone rhythm modulates pineal function through NFκB-related gene transcriptional program

(2017) Sanseray da Silveira Cruz-Machado et al.   Scientific Reports

The Microbiome-Mitochondrion Connection: Common Ancestries, Common Mechanisms, Common Goals

(2017) Alfredo Franco-Obregón et al.   mSystems

Melatonin production in Escherichia coli by dual expression of serotonin N-acetyltransferase and caffeic acid O-methyltransferase

(2016) Yeong Byeon et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Melatonin in the Regulation of Differentiation of T Cells Producing Interleukin-17 (Th17)

(2016) E. M. Kuklina et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Gut Microbial Metabolites Fuel Host Antibody Responses

(2016) Myunghoo Kim et al.   Cell Host & Microbe

Possible Involvement of the Inhibition of NF-κB Factor in Anti-Inflammatory Actions That Melatonin Exerts on Mast Cells

(2016) M.D. Maldonado et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts

(2016) Kyoungwhan Back et al.   JOURNAL OF PINEAL RESEARCH

The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages

(2016) Sandra Marcia Muxel et al.   JOURNAL OF PINEAL RESEARCH

On the significance of an alternate pathway of melatonin synthesis via 5-methoxytryptamine: comparisons across species

(2016) Dun-Xian Tan et al.   JOURNAL OF PINEAL RESEARCH

The nuclear melatonin receptor RORαis a novel endogenous defender against myocardial ischemia/reperfusion injury

(2016) Ben He et al.   JOURNAL OF PINEAL RESEARCH

Human Gut Bacteria Are Sensitive to Melatonin and Express Endogenous Circadian Rhythmicity

(2016) Jiffin K. Paulose et al.   PLoS One

Melatonin-Producing Endophytic Bacteria from Grapevine Roots Promote the Abiotic Stress-Induced Production of Endogenous Melatonin in Their Hosts

(2016) Jian Jiao et al.   Frontiers in Plant Science

Gut Microbiota Modification: Another Piece in the Puzzle of the Benefits of Physical Exercise in Health?

(2016) Begoña Cerdá et al.   Frontiers in Physiology

T lymphocytes possess the machinery for 5-HT synthesis, storage, degradation and release

(2015) Y. Chen et al.   Acta Physiologica

Circadian rhythms, alcohol and gut interactions

(2015) Christopher B. Forsyth et al.   ALCOHOL

Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism

(2015) Vanessa Leone et al.   Cell Host & Microbe

Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis

(2015) Jingshu Chen et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

T cell subsets and their signature cytokines in autoimmune and inflammatory diseases

(2015) Itay Raphael et al.   CYTOKINE

Quinone reductase 2 as a promising target of melatonin therapeutic actions

(2015) Jean A Boutin   EXPERT OPINION ON THERAPEUTIC TARGETS

Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway

(2015) Erika Cecon et al.   FASEB JOURNAL

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A

(2015) Jeffrey J. Bunker et al.   IMMUNITY

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

(2015) Dun-Xian Tan et al.   MOLECULES

Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation

(2015) Clara Moon et al.   NATURE

Pathophysiology of T follicular helper cells in humans and mice

(2015) Hideki Ueno et al.   NATURE IMMUNOLOGY

A novel synthetic derivative of melatonin, 5-hydroxy-2’-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation

(2015) Do-Wan Shim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Stearic acid induces proinflammatory cytokine production partly through activation of lactate-HIF1α pathway in chondrocytes

(2015) Hongming Miao et al.   Scientific Reports

Development and Function of Protective and Pathologic Memory CD4 T Cells

(2015) Shafqat Ahrar Jaigirdar et al.   Frontiers in Immunology

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cyclic-3-hydroxymelatonin (C3HOM), A Potent Antioxidant, Scavenges Free Radicals and Suppresses Oxidative Reactions

(2014) Dun-Xian Tan et al.   CURRENT MEDICINAL CHEMISTRY

Mast cell activation: A complex interplay of positive and negative signaling pathways

(2014) Riccardo Sibilano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Pregnane X Receptor as the “Sensor and Effector” in Regulating Epigenome

(2014) Xi Ma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Redox Regulation of Inflammation: Old Elements, a New Story

(2014) Yunlong Lei et al.   MEDICINAL RESEARCH REVIEWS

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

(2014) Nathalie Schmitt et al.   NATURE IMMUNOLOGY

Melatonin for the treatment of irritable bowel syndrome

(2014) Kewin Tien Ho Siah   WORLD JOURNAL OF GASTROENTEROLOGY

T Cell–Mediated Host Immune Defenses in the Lung

(2013) Kong Chen et al.   Annual Review of Immunology

Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs

(2013) Atish Mukherji et al.   CELL

Bacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila

(2013) Kyung-Ah Lee et al.   CELL

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Melatonin receptor subtypes Mel1a and Mel1c but not Mel1b are associated with monochromatic light-induced B-lymphocyte proliferation in broilers

(2013) J. Li et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome

(2013) Dan Knights et al.   GUT

Immune-Pineal Axis: Nuclear Factor κB (NF-kB) Mediates the Shift in the Melatonin Source from Pinealocytes to Immune Competent Cells

(2013) Regina Markus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells

(2013) Marco A. Pires-Lapa et al.   JOURNAL OF PINEAL RESEARCH

Norepinephrine activates NF-κB transcription factor in cultured rat pineal gland

(2013) Darine Villela et al.   LIFE SCIENCES

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Minimal NF-κB activity in neurons

(2013) S.J. Listwak et al.   NEUROSCIENCE

TH17 Cell Differentiation Is Regulated by the Circadian Clock

(2013) X. Yu et al.   SCIENCE

Autophagy in the intestinal epithelium regulates Citrobacter rodentium infection

(2012) Jun Inoue et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Partner Burden in Irritable Bowel Syndrome

(2012) Reuben K. Wong et al.   Clinical Gastroenterology and Hepatology

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-κB, c/EBPβ, and p300 signaling

(2012) Dingbo Shi et al.   JOURNAL OF PINEAL RESEARCH

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

NF-κB Drives the Synthesis of Melatonin in RAW 264.7 Macrophages by Inducing the Transcription of the Arylalkylamine-N-Acetyltransferase (AA-NAT) Gene

(2012) Sandra Marcia Muxel et al.   PLoS One

Neuromodulatory role of melatonin in retinal information processing

(2012) Hai Huang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

TLR signaling in mast cells: common and unique features

(2012) Hilary Sandig et al.   Frontiers in Immunology

NFIL3/E4BP4 is a key transcription factor for CD8 + dendritic cell development

(2011) M. Kashiwada et al.   BLOOD

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

(2011) Shingo Nakayamada et al.   IMMUNITY

NFIL3 Is a Regulator of IL-12 p40 in Macrophages and Mucosal Immunity

(2011) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Mast Cells as Sensors of Cell Injury through IL-33 Recognition

(2011) M. Enoksson et al.   JOURNAL OF IMMUNOLOGY

Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor

(2011) Patricia J. Lardone et al.   JOURNAL OF PINEAL RESEARCH

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

(2011) Jörg H. Stehle et al.   JOURNAL OF PINEAL RESEARCH

Evidence that membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in the neuroprotective effects of melatonin in focal cerebral ischemia

(2011) Ulkan Kilic et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Distribution, function and physiological role of melatonin in the lower gut

(2011) Chun-Qiu Chen   WORLD JOURNAL OF GASTROENTEROLOGY

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Blocking of melatonin synthesis and MT1 receptor impairs the activation of Jurkat T cells

(2010) Patricia J. Lardone et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Melatonin Metabolism in the Central Nervous System

(2010) Rudiger Hardeland   Current Neuropharmacology

Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes

(2010) Cedric Vonarbourg et al.   IMMUNITY

Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-κB and STAT1 activity

(2010) Eun-Young Choi et al.   JOURNAL OF PINEAL RESEARCH

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

(2010) Giuseppe Paradies et al.   JOURNAL OF PINEAL RESEARCH

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology

(2010) Sofia Buonocore et al.   NATURE

Lineage Relationship Analysis of RORγt+Innate Lymphoid Cells

(2010) Shinichiro Sawa et al.   SCIENCE

Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin

(2009) Russel J. Reiter et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Age-related changes in melatonin synthesis in rat extrapineal tissues

(2009) M. Sanchez-Hidalgo et al.   EXPERIMENTAL GERONTOLOGY

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

(2009) Valérie Gaboriau-Routhiau et al.   IMMUNITY

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

(2009) Rüdiger Hardeland et al.   JOURNAL OF PINEAL RESEARCH

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

(2009) Brittney Jung-Hynes et al.   JOURNAL OF PINEAL RESEARCH

Do symbiotic bacteria subvert host immunity?

(2009) Lora V. Hooper   NATURE REVIEWS MICROBIOLOGY

Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation

(2009) M.D. Maldonado et al.   PHARMACOLOGICAL RESEARCH

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

ERK MAPK activation mediates the antiapoptotic signaling of melatonin in UVB-stressed U937 cells

(2008) F. Luchetti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Macrophages in the embryo and beyond: Much more than just giant phagocytes

(2008) Dmitry A. Ovchinnikov   GENESIS

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

(2008) Naoko Satoh-Takayama et al.   IMMUNITY

Metabolism of melatonin by cytochrome P450s in rat liver mitochondria and microsomes

(2008) Igor Semak et al.   JOURNAL OF PINEAL RESEARCH

Decreased MT1 and MT2 melatonin receptor expression in extrapineal tissues of the rat during physiological aging

(2008) Marina Sánchez-Hidalgo et al.   JOURNAL OF PINEAL RESEARCH

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Updates on treatment of irritable bowel syndrome

(2008) Christopher W Hammerle et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Melatonin as an antibiotic: new insights into the actions of this ubiquitous molecule

(2007) Omer Faruk Tekbas et al.   JOURNAL OF PINEAL RESEARCH