Basic understanding and therapeutic approaches to target toll-like receptors in cancerous microenvironment and metastasis

Toll-like receptor stimulation in cancer: A pro- and anti-tumor double-edged sword

(2017) Marion Dajon et al.   IMMUNOBIOLOGY

EMT and inflammation: inseparable actors of cancer progression

(2017) Meggy Suarez-Carmona et al.   Molecular Oncology

A phase 2 study of TMX-101, intravesical imiquimod, for the treatment of carcinoma in situ bladder cancer

(2017) Nicholas M. Donin et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Topical Imiquimod Plus Nab-paclitaxel for Breast Cancer Cutaneous Metastases

(2017) Lupe G. Salazar et al.   JAMA Oncology

The critical role of toll-like receptors — From microbial recognition to autoimmunity: A comprehensive review

(2016) Maximiliano Javier Jiménez-Dalmaroni et al.   AUTOIMMUNITY REVIEWS

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Toll-like receptor 2 in host defense against Mycobacterium tuberculosis : to be or not to be — that is the question

(2016) Archana Gopalakrishnan et al.   CURRENT OPINION IN IMMUNOLOGY

Exploring the role of inflammation in the malignant transformation of low-grade gliomas

(2016) Nicole Michelson et al.   JOURNAL OF NEUROIMMUNOLOGY

Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms

(2016) A C Herman et al.   Blood Cancer Journal

Microbially Driven TLR5-Dependent Signaling Governs Distal Malignant Progression through Tumor-Promoting Inflammation

(2015) Melanie R. Rutkowski et al.   CANCER CELL

A randomized pilot trial testing the safety and immunologic effects of a MAGE-A3 protein plus AS15 immunostimulant administered into muscle or into dermal/subcutaneous sites

(2015) Craig L. Slingluff et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity

(2015) D. Geng et al.   CANCER RESEARCH

TLR2 Limits Development of Hepatocellular Carcinoma by Reducing IL18-Mediated Immunosuppression

(2015) S. Li et al.   CANCER RESEARCH

The Role of TLR4 in Chemotherapy-Driven Metastasis

(2015) S. Ran   CANCER RESEARCH

Local administration of a novel Toll-like receptor 7 agonist in combination with doxorubicin induces durable tumouricidal effects in a murine model of T cell lymphoma

(2015) Jiang Zhu et al.   Journal of Hematology & Oncology

The lung metastatic niche

(2015) Yoshiro Maru   JOURNAL OF MOLECULAR MEDICINE-JMM

The brain metastatic niche

(2015) Frank Winkler   JOURNAL OF MOLECULAR MEDICINE-JMM

The lymph node pre-metastatic niche

(2015) Jonathan P. Sleeman   JOURNAL OF MOLECULAR MEDICINE-JMM

Bacille Calmette-Guerin can induce cellular apoptosis of urothelial cancer directly through toll-like receptor 7 activation

(2015) Dah-Shyong Yu et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors

(2015) T. Sato et al.   MOLECULAR CANCER THERAPEUTICS

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Hepatic metastatic niche: from normal to pre-metastatic and metastatic niche

(2015) Shirin Azizidoost et al.   TUMOR BIOLOGY

Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer

(2015) Yun Luo et al.   Oncotarget

Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma

(2015) Lovisa Farnebo et al.   Oncotarget

PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo

(2015) R. Takemura et al.   Cancer Immunology Research

The inflammatory role of platelets via their TLRs and Siglec receptors

(2015) Fabrice Cognasse   Frontiers in Immunology

Immune modulating effects of cyclophosphamide and treatment with tumor lysate/CpG synergize to eliminate murine neuroblastoma

(2015) Jill A. Gershan et al.   Journal for ImmunoTherapy of Cancer

Targeting the NF-κB Pathway as a Combination Therapy for Advanced Thyroid Cancer

(2015) Nikita Pozdeyev et al.   PLoS One

Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses

(2014) Megumi Tatematsu et al.   BIOCHEMICAL JOURNAL

Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis

(2014) S. Boettcher et al.   BLOOD

Paclitaxel Therapy Promotes Breast Cancer Metastasis in a TLR4-Dependent Manner

(2014) L. Volk-Draper et al.   CANCER RESEARCH

TLR7 Promotes Tumor Progression, Chemotherapy Resistance, and Poor Clinical Outcomes in Non-Small Cell Lung Cancer

(2014) S. Chatterjee et al.   CANCER RESEARCH

TLRs: Linking inflammation and breast cancer

(2014) Khyati Bhatelia et al.   CELLULAR SIGNALLING

Role of Toll-like receptors in cervical, endometrial and ovarian cancers: A review

(2014) Nader Husseinzadeh et al.   GYNECOLOGIC ONCOLOGY

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids

(2014) Maximiliano J Jiménez-Dalmaroni et al.   Innate Immunity

Imiquimod Inhibits Melanoma Development by Promoting pDC Cytotoxic Functions and Impeding Tumor Vascularization

(2014) Caroline Aspord et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Human TLR10 is an anti-inflammatory pattern-recognition receptor

(2014) Marije Oosting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer

(2013) Laure Belmont et al.   INTERNATIONAL JOURNAL OF CANCER

TLR agonists: our best frenemy in cancer immunotherapy

(2013) Sabina Kaczanowska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TLR4 Is a Novel Determinant of the Response to Paclitaxel in Breast Cancer

(2013) S. Rajput et al.   MOLECULAR CANCER THERAPEUTICS

Inhibitory effect of dsRNA TLR3 agonist in a rat hepatocellular carcinoma model

(2013) YU-YIN XU et al.   Molecular Medicine Reports

Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice

(2013) Ying Zhao et al.   PLoS One

E-cadherin promotes proliferation of human ovarian cancer cells in vitro via activating MEK/ERK pathway

(2012) Ling-ling Dong et al.   ACTA PHARMACOLOGICA SINICA

The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL

(2012) Yury I Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Molecular evolution of vertebrate Toll-like receptors: Evolutionary rate difference between their leucine-rich repeats and their TIR domains

(2012) Tomoko Mikami et al.   GENE

NF-κB as potential target in the treatment of melanoma

(2012) Gabriele Madonna et al.   Journal of Translational Medicine

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Type I interferon response and innate immune sensing of cancer

(2012) Mercedes B. Fuertes et al.   TRENDS IN IMMUNOLOGY

Signaling in Innate Immunity and Inflammation

(2012) K. Newton et al.   Cold Spring Harbor Perspectives in Biology

Randomized clinical trial of imiquimod: an adjunct to treating cervical dysplasia

(2011) Deirdre R. Pachman et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Anticancer function of polyinosinic-polycytidylic acid

(2011) Yu-sheng Cheng et al.   CANCER BIOLOGY & THERAPY

Tissue expression of Toll-like receptors 2 and 4 in sporadic human colorectal cancer

(2011) Yasuhiro Nihon-Yanagi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer

(2010) E L Wang et al.   BRITISH JOURNAL OF CANCER

TLR3 activation inhibits nasopharyngeal carcinoma metastasis via down-regulation of chemokine receptor CXCR4

(2010) Yu Zhang et al.   CANCER BIOLOGY & THERAPY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Oncogenic Activation of NF- B

(2010) L. M. Staudt   Cold Spring Harbor Perspectives in Biology

Silencing of TLR4 Decreases Liver Tumor Burden in a Murine Model of Colorectal Metastasis and Hepatic Steatosis

(2009) T. M. Earl et al.   ANNALS OF SURGICAL ONCOLOGY

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-κB-dependent activation of the urokinase plasminogen activator system

(2009) S D Killeen et al.   BRITISH JOURNAL OF CANCER

The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer

(2009) Tsukasa Seya et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas

(2009) Camilla Rydberg et al.   IMMUNOLOGY

TLR3: Interferon induction by double-stranded RNA including poly(I:C)☆

(2008) M MATSUMOTO et al.   ADVANCED DRUG DELIVERY REVIEWS

Evolution of the chicken Toll-like receptor gene family: A story of gene gain and gene loss

(2008) Nicholas D Temperley et al.   BMC GENOMICS

Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC- -dependent mechanism

(2008) A. Paone et al.   CARCINOGENESIS

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY

The role of non-steroidal anti-inflammatory drugs in the risk of development and treatment of hematologic malignancies

(2008) Pawel Robak et al.   LEUKEMIA & LYMPHOMA

TLR signaling by tumor and immune cells: a double-edged sword

(2008) B Huang et al.   ONCOGENE

The tumor microenvironment and its role in promoting tumor growth

(2008) T L Whiteside   ONCOGENE