Dietary Amino Acids and the Gut-Microbiome-Immune Axis: Physiological Metabolism and Therapeutic Prospects

The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get

(2018) Jia Yang et al.   Protein & Cell

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

(2018) Ning Ma et al.   Frontiers in Immunology

Glutamine Metabolism and Function in Relation to Proline Synthesis and the Safety of Glutamine and Proline Supplementation

(2018) Malcolm Watford   JOURNAL OF NUTRITION

Dietary tryptophan alleviates dextran sodium sulfate-induced colitis through aryl hydrocarbon receptor in mice

(2017) Jahidul Islam et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Variations in gut microbiota and fecal metabolic phenotype associated with depression by 16S rRNA gene sequencing and LC/MS-based metabolomics

(2017) Meng Yu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Feedback control of AHR signalling regulates intestinal immunity

(2017) Chris Schiering et al.   NATURE

The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4

(2016) Xiaoxia Gao et al.   BIOCHEMICAL PHARMACOLOGY

The gut microbiota: A treasure for human health

(2016) Daotong Li et al.   BIOTECHNOLOGY ADVANCES

Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

(2016) Melanie Schirmer et al.   CELL

Glutamine promotes intestinal SIgA secretion through intestinal microbiota and IL-13

(2016) Miaomiao Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Regulating inflammation with microbial metabolites

(2016) Benjamin J Marsland   NATURE MEDICINE

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

Protective effect of tryptophan against dextran sulfate sodium- induced experimental colitis

(2016) Toru SHIZUMA et al.   Turkish Journal of Gastroenterology

Interactions Between the Gastrointestinal Microbiome and Clostridium difficile

(2015) Casey M. Theriot et al.   Annual Review of Microbiology

Effects of particle size and drying methods of corn on growth performance, digestibility and haematological and immunological characteristics of weaned piglets

(2015) Chang Huang et al.   ARCHIVES OF ANIMAL NUTRITION

Antimicrobial peptide-based treatment for endodontic infections — Biotechnological innovation in endodontics

(2015) Stella Maris de Freitas Lima et al.   BIOTECHNOLOGY ADVANCES

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Editorial (Thematic Issue: Advance of Interactions Between Exogenous Natural Bioactive Peptides and Intestinal Barrier and Immune Responses)

(2015) Wenhui Wang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Interaction between Microbes and Host Intestinal Health: Modulation by Dietary Nutrients and Gut-Brain-Endocrine-Immune Axis

(2015) Jingshu Chen et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Metabolites of Dietary Protein and Peptides by Intestinal Microbes and their Impacts on Gut

(2015) Peixin Fan et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

Inherited CARD9 deficiency in otherwise healthy children and adults with Candida species–induced meningoencephalitis, colitis, or both

(2015) Fanny Lanternier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease

(2015) Matthew J. Kan et al.   JOURNAL OF NEUROSCIENCE

High Amylose Starch with Low In Vitro Digestibility Stimulates Hindgut Fermentation and Has a Bifidogenic Effect in Weaned Pigs

(2015) Janelle M Fouhse et al.   JOURNAL OF NUTRITION

Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets

(2015) Chang Huang et al.   JOURNAL OF NUTRITION

Amino acid metabolism in intestinal bacteria and its potential implications for mammalian reproduction

(2015) Z. Dai et al.   MOLECULAR HUMAN REPRODUCTION

Visceral hypersensitivity in irritable bowel syndrome: evidence for involvement of serotonin metabolism - a preliminary study

(2015) D. Keszthelyi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Toll-like receptors 2 and 4 modulate the contractile response induced by serotonin in mouse ileum: analysis of the serotonin receptors involved

(2015) R. Forcén et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Small-intestinal or colonic microbiota as a potential amino acid source in animals

(2014) Werner G. Bergen   AMINO ACIDS

Important impacts of intestinal bacteria on utilization of dietary amino acids in pigs

(2014) Yu-Xiang Yang et al.   AMINO ACIDS

Uptake of Amino Acids and Their Metabolic Conversion into the Compatible Solute Proline Confers Osmoprotection to Bacillus subtilis

(2014) Adrienne Zaprasis et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metabolite induction via microorganism co-culture: A potential way to enhance chemical diversity for drug discovery

(2014) Samuel Bertrand et al.   BIOTECHNOLOGY ADVANCES

Discovery and Characterization of Gut Microbiota Decarboxylases that Can Produce the Neurotransmitter Tryptamine

(2014) Brianna B. Williams et al.   Cell Host & Microbe

The Cytokine IL-22 Promotes Pathogen Colonization by Suppressing Related Commensal Bacteria

(2014) Judith Behnsen et al.   IMMUNITY

Identification of a probiotic bacteria-derived activator of the aryl hydrocarbon receptor that inhibits colitis

(2014) Suguru Fukumoto et al.   IMMUNOLOGY AND CELL BIOLOGY

Oral Administration of Lactobacillus fermentum I5007 Favors Intestinal Development and Alters the Intestinal Microbiota in Formula-Fed Piglets

(2014) Hong Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Molecular and Cellular Roles of PI31 (PSMF1) Protein in Regulation of Proteasome Function

(2014) Xiaohua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Type-Specific Regulation of ITAM-Mediated NF- B Activation by the Adaptors, CARMA1 and CARD9

(2014) H. Hara et al.   JOURNAL OF IMMUNOLOGY

Differential Use of CARD9 by Dectin-1 in Macrophages and Dendritic Cells

(2014) H. S. Goodridge et al.   JOURNAL OF IMMUNOLOGY

Enteral Nutrition in the Management of Pediatric Intestinal Failure

(2014) Kerri B. Gosselin et al.   JOURNAL OF PEDIATRICS

AhR sensing of bacterial pigments regulates antibacterial defence

(2014) Pedro Moura-Alves et al.   NATURE

Gut microbiota–generated metabolites in animal health and disease

(2014) Won-Jae Lee et al.   Nature Chemical Biology

Coordination of microbial metabolism

(2014) Victor Chubukov et al.   NATURE REVIEWS MICROBIOLOGY

Natural compounds boldine and menthol are antagonists of human 5-HT3receptors: implications for treating gastrointestinal disorders

(2014) J. Walstab et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Evolution of Mitochondrial Power in Vertebrate Metazoans

(2014) Yasuhiro Kitazoe et al.   PLoS One

Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome

(2014) C. Stasi et al.   Techniques in Coloproctology

Fertilizer and sanitary quality of digestate biofertilizer from the co-digestion of food waste and human excreta

(2014) H.I. Owamah et al.   WASTE MANAGEMENT

Amino Acid Nutrition in Animals: Protein Synthesis and Beyond

(2014) Guoyao Wu et al.   Annual Review of Animal Biosciences

Quorum sensing in group A Streptococcus

(2014) Juan Cristobal Jimenez et al.   Frontiers in Cellular and Infection Microbiology

Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health: a review

(2013) V. T. S. Rist et al.   Animal

Primary tumor location and bevacizumab effectiveness in patients with metastatic colorectal cancer

(2013) M. K. Boisen et al.   ANNALS OF ONCOLOGY

Branched-chain amino acids influence the immune properties of microglial cells and their responsiveness to pro-inflammatory signals

(2013) Roberta De Simone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Indole-3-Acetic Acid Production by Endophytic Streptomyces sp. En-1 Isolated from Medicinal Plants

(2013) Lan Lin et al.   CURRENT MICROBIOLOGY

ZBP-89 Regulates Expression of Tryptophan Hydroxylase I and Mucosal Defense Against Salmonella Typhimurium in Mice

(2013) Bryan E. Essien et al.   GASTROENTEROLOGY

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

(2013) Paola Brun et al.   GASTROENTEROLOGY

Card9 Mediates Intestinal Epithelial Cell Restitution, T-Helper 17 Responses, and Control of Bacterial Infection in Mice

(2013) Harry Sokol et al.   GASTROENTEROLOGY

Complex Interactions Among Diet, Gastrointestinal Transit, and Gut Microbiota in Humanized Mice

(2013) Purna C. Kashyap et al.   GASTROENTEROLOGY

Glucocorticoids and microbiota regulate ontogeny of intestinal fucosyltransferase 2 requisite for gut homeostasis

(2013) N. N. Nanthakumar et al.   GLYCOBIOLOGY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Butyrate promotes the recovering of intestinal wound healing through its positive effect on the tight junctions1

(2013) X. Ma et al.   JOURNAL OF ANIMAL SCIENCE

BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid

(2013) Chuanwu Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

Complex Dietary Protein Improves Growth Through a Complex Mechanism of Intestinal Peptide Absorption and Protein Digestion

(2013) Stephanie A. Hansen et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

Visceral hypersensitivity in female but not in male serotonin transporter knockout rats

(2013) J. J. Galligan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic Digestive Enzyme Blockade in the Small Intestine Prevents Insulin Resistance in Hemorrhagic Shock

(2013) Frank A. DeLano et al.   SHOCK

The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A

(2013) Shoko Sato et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Gut microbiota, host health, and polysaccharides

(2012) Xiaofei Xu et al.   BIOTECHNOLOGY ADVANCES

Innate immunity in the small intestine

(2012) Rebeca Santaolalla et al.   CURRENT OPINION IN GASTROENTEROLOGY

Bacteria, Colonic Fermentation, and Gastrointestinal Health

(2012) George T. Macfarlane et al.   JOURNAL OF AOAC INTERNATIONAL

The gut microbiota regulates bone mass in mice

(2012) Klara Sjögren et al.   JOURNAL OF BONE AND MINERAL RESEARCH

LOC66273 Isoform 2, a Novel Protein Highly Expressed in White Adipose Tissue, Induces Adipogenesis in 3T3-L1 Cells

(2012) Xi Ma et al.   JOURNAL OF NUTRITION

Tryptamine Serves As a Proligand of the AhR Transcriptional Pathway Whose Activation Is Dependent of Monoamine Oxidases

(2012) Linda Vikström Bergander et al.   MOLECULAR ENDOCRINOLOGY

The interplay between the intestinal microbiota and the brain

(2012) Stephen M. Collins et al.   NATURE REVIEWS MICROBIOLOGY

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host

(2012) Anne-Marie Davila et al.   PHARMACOLOGICAL RESEARCH

Novel, Objective, Multivariate Biomarkers Composed of Plasma Amino Acid Profiles for the Diagnosis and Assessment of Inflammatory Bowel Disease

(2012) Tadakazu Hisamatsu et al.   PLoS One

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome

(2012) Sahar Abubucker et al.   PLoS Computational Biology

Metabolism of select amino acids in bacteria from the pig small intestine

(2011) Zhao-Lai Dai et al.   AMINO ACIDS

Probiotics function mechanistically as delivery vehicles for neuroactive compounds: Microbial endocrinology in the design and use of probiotics

(2011) Mark Lyte   BIOESSAYS

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

A Role of the Aryl Hydrocarbon Receptor in Attenuation of Colitis

(2011) Keisuke Furumatsu et al.   DIGESTIVE DISEASES AND SCIENCES

Regulation of the IL-10/IL-12 axis in human dendritic cells with probiotic bacteria

(2011) Monika Gad et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Innate immune signaling in defense against intestinal microbes

(2011) Melissa A. Kinnebrew et al.   IMMUNOLOGICAL REVIEWS

Dietary Grape-Seed Procyanidins Decreased Postweaning Diarrhea by Modulating Intestinal Permeability and Suppressing Oxidative Stress in Rats

(2011) Peixia Song et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

First-pass splanchnic metabolism of dietary cysteine in weanling pigs1

(2011) C. Bauchart-Thevret et al.   JOURNAL OF ANIMAL SCIENCE

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Therapeutics of 5-HT3 receptor antagonists: Current uses and future directions

(2011) Tina K. Machu   PHARMACOLOGY & THERAPEUTICS

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli

(2011) Pieter Van den Abbeele et al.   Microbial Biotechnology

Utilization of amino acids by bacteria from the pig small intestine

(2010) Zhao-Lai Dai et al.   AMINO ACIDS

Amino acid metabolism in intestinal bacteria: links between gut ecology and host health

(2010) Zhao-Lai Dai   Frontiers in Bioscience-Landmark

Control of immune response by amino acid metabolism

(2010) Ursula Grohmann et al.   IMMUNOLOGICAL REVIEWS

Toll-like receptors in inflammatory bowel diseases: A decade later

(2010) Elke Cario   INFLAMMATORY BOWEL DISEASES

Assessing Gut Microbial Diversity from Feces and Rectal Mucosa

(2010) Ana Durbán et al.   MICROBIAL ECOLOGY

Reversible Microbial Colonization of Germ-Free Mice Reveals the Dynamics of IgA Immune Responses

(2010) S. Hapfelmeier et al.   SCIENCE

Metabolism and functions of l-glutamate in the epithelial cells of the small and large intestines

(2009) François Blachier et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metabolic fate and function of dietary glutamate in the gut

(2009) Douglas G Burrin et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Catabolism of nutritionally essential amino acids in developing porcine enterocytes

(2009) Lixiang Chen et al.   AMINO ACIDS

Luminal sulfide and large intestine mucosa: friend or foe?

(2009) François Blachier et al.   AMINO ACIDS

Amino acids: metabolism, functions, and nutrition

(2009) Guoyao Wu   AMINO ACIDS

Diversity of Clostridium difficile in pigs and other animals in Slovenia

(2009) Jana Avbersek et al.   ANAEROBE

Expression of short-chain fatty acid receptor GPR41 in the human colon

(2009) Hideaki Tazoe et al.   BIOMEDICAL RESEARCH-TOKYO

Almost all enteral aspartate is taken up in first-pass metabolism in enterally fed preterm infants

(2009) Willemijn E. Corpeleijn et al.   CLINICAL NUTRITION

The role of pH in determining the species composition of the human colonic microbiota

(2009) Sylvia H. Duncan et al.   ENVIRONMENTAL MICROBIOLOGY

The role of innate signaling in the homeostasis of tolerance and immunity in the intestine

(2009) Jerry M. Wells et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Role of autoinducer-2 on the adhesion ability ofLactobacillus acidophilus

(2009) B.L. Buck et al.   JOURNAL OF APPLIED MICROBIOLOGY

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary and Endogenous Amino Acids Are the Main Contributors to Microbial Protein in the Upper Gut of Normally Nourished Pigs

(2009) Aileen Joy O. Libao-Mercado et al.   JOURNAL OF NUTRITION

l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis

(2009) Connie J. Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function

(2009) d. keszthelyi et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Interactions of gut microbiota with functional food components and nutraceuticals

(2009) J.M. Laparra et al.   PHARMACOLOGICAL RESEARCH

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

(2009) W. R. Wikoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

16S ribosomal RNA-based methods to monitor changes in the hindgut bacterial community of piglets after oral administration of Lactobacillus sobrius S1

(2008) Yong Su et al.   ANAEROBE

Occurrence of Agmatine Pathway for Putrescine Synthesis inSelenomonas ruminatium

(2008) Shaofu LIAO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Detection of Autoinducer-2 and Analysis of the Profile of luxS and pfs Transcription in Streptococcus suis Serotype 2

(2008) X. G. Han et al.   CURRENT MICROBIOLOGY

Human colonic microbiota associated with diet, obesity and weight loss

(2008) S H Duncan et al.   INTERNATIONAL JOURNAL OF OBESITY

SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity

(2008) Swami R. Narala et al.   MOLECULAR BIOLOGY OF THE CELL

Amino acid-dependent growth ofCampylobacter jejuni: key roles for aspartase (AspA) under microaerobic and oxygen-limited conditions and identification of AspB (Cj0762), essential for growth on glutamate

(2008) Edward Guccione et al.   MOLECULAR MICROBIOLOGY

Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes

(2008) Sandrine P Claus et al.   Molecular Systems Biology

Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model

(2008) Francois-Pierre J Martin et al.   Molecular Systems Biology

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

(2008) Katharina Brandl et al.   NATURE

Butyrate Transcriptionally Enhances Peptide Transporter PepT1 Expression and Activity

(2008) Guillaume Dalmasso et al.   PLoS One

Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants

(2008) Katerina V. Savelieva et al.   PLoS One