Recent progress and challenges in drug development to fight hand, foot and mouth disease

Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses

(2019) Jinhuan Chen et al.   Cell Discovery

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors

(2019) Yiqing Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and characterization of an enterovirus 71 (EV71) virus-like particles (VLPs) vaccine produced in Pichia pastoris

(2019) Zhijian Yang et al.   Human Vaccines & Immunotherapeutics

KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses

(2018) Jacqueline Staring et al.   Cell Host & Microbe

CRISPR–Cas9 Genetic Analysis of Virus–Host Interactions

(2018) Makda Gebre et al.   Viruses-Basel

Genome-wide CRISPR/Cas9 Screen Identifies Host Factors Essential for Influenza Virus Replication

(2018) Julianna Han et al.   Cell Reports

Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis

(2018) Issac Horng Khit Too et al.   PLoS Pathogens

Enterovirus A71 Proteins: Structure and Function

(2018) Jingjing Yuan et al.   Frontiers in Microbiology

Ending Use of Oral Poliovirus Vaccine — A Difficult Move in the Polio Endgame

(2018) Mark A. Pallansch   NEW ENGLAND JOURNAL OF MEDICINE

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

The mechanism of resistance to favipiravir in influenza

(2018) Daniel H. Goldhill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy

(2018) Chiaho Shih et al.   Viruses-Basel

A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants

(2018) Ryan P. Trombetta et al.   mSphere

Enterovirus 3A Facilitates Viral Replication by Promoting Phosphatidylinositol 4-Kinase IIIβ–ACBD3 Interaction

(2017) Xia Xiao et al.   JOURNAL OF VIROLOGY

Exploring and Exploiting Proteome Organization during Viral Infection

(2017) Pierre M. Jean Beltran et al.   JOURNAL OF VIROLOGY

Glycoproteomics: A Balance between High-Throughput and In-Depth Analysis

(2017) Yang Yang et al.   TRENDS IN BIOTECHNOLOGY

The Golgi protein ACBD3 facilitates Enterovirus 71 replication by interacting with 3A

(2017) Xiaobo Lei et al.   Scientific Reports

Direct-acting antivirals and host-targeting strategies to combat enterovirus infections

(2017) Lisa Bauer et al.   Current Opinion in Virology

Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A

(2017) Peijun Ren et al.   Scientific Reports

Effective in vivo therapeutic IgG antibody against VP3 of enterovirus 71 with receptor-competing activity

(2017) Qiang Jia et al.   Scientific Reports

In VitroAssessment of Combinations of Enterovirus Inhibitors against Enterovirus 71

(2016) Yizhuo Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71

(2016) Eva Rivero-Buceta et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C

(2016) Rachel Ulferts et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds

(2016) Donald F. Smee et al.   ANTIVIRAL RESEARCH

Efficacy and safety of interferon-α2b spray in the treatment of hand, foot, and mouth disease: a multicenter, randomized, double-blind trial

(2016) Hailong Lin et al.   ARCHIVES OF VIROLOGY

Drug screening using model systems: some basics

(2016) Ross Cagan   Disease Models & Mechanisms

Idarubicin is a broad-spectrum enterovirus replication inhibitor that selectively targets the virus internal ribosomal entry site

(2016) Hsin-Yu Hou et al.   JOURNAL OF GENERAL VIROLOGY

2-Year Efficacy, Immunogenicity, and Safety of Vigoo Enterovirus 71 Vaccine in Healthy Chinese Children: A Randomized Open-Label Study

(2016) Mingwei Wei et al.   JOURNAL OF INFECTIOUS DISEASES

Enterovirus 71 2B Induces Cell Apoptosis by Directly Inducing the Conformational Activation of the Proapoptotic Protein Bax

(2016) Haolong Cong et al.   JOURNAL OF VIROLOGY

Clinical Efficacy of Therapy with Recombinant Human Interferon α1b in Hand, Foot, and Mouth Disease with Enterovirus 71 Infection

(2016) Xueyong Huang et al.   PLoS One

Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf

(2016) Matthias Zebisch et al.   STRUCTURE

Antiviral activity of micafungin against enterovirus 71

(2016) Chonsaeng Kim et al.   Virology Journal

Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells

(2016) Di Sun et al.   Viruses-Basel

Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication

(2016) Kan Xing Wu et al.   Nature Communications

Discovery of Itraconazole with Broad-SpectrumIn VitroAntienterovirus Activity That Targets Nonstructural Protein 3A

(2015) Qianqian Gao et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multifaceted role of prohibitin in cell survival and apoptosis

(2015) Ya-Ting Peng et al.   APOPTOSIS

VCP and PSMF1: Antagonistic regulators of proteasome activity

(2015) Christoph S. Clemen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Socioeconomic burden of hand, foot and mouth disease in children in Shanghai, China

(2015) Z. L. WANG et al.   EPIDEMIOLOGY AND INFECTION

Proteomics Analysis of EV71-Infected Cells Reveals the Involvement of Host Protein NEDD4L in EV71 Replication

(2015) Rei-Lin Kuo et al.   JOURNAL OF PROTEOME RESEARCH

Cellular proteome alterations in response to enterovirus 71 and coxsackievirus A16 infections in neuronal and intestinal cell lines

(2015) Shie Yien Chan et al.   Journal of Proteomics

Cell Surface Nucleolin Facilitates Enterovirus 71 Binding and Infection

(2015) Pei-Yi Su et al.   JOURNAL OF VIROLOGY

Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A

(2015) Minetaro Arita et al.   MICROBIOLOGY AND IMMUNOLOGY

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses

(2015) Céline Lacroix et al.   Virology Journal

The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

(2015) Xiang Li et al.   Viruses-Basel

Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein

(2015) Jeroen R.P.M. Strating et al.   Cell Reports

A Strategy for O-Glycoproteomics of Enveloped Viruses—the O-Glycoproteome of Herpes Simplex Virus Type 1

(2015) Ieva Bagdonaite et al.   PLoS Pathogens

Monoclonal neutralizing antibodies against EV71 screened from mice immunized with yeast-produced virus-like particles

(2015) Tao Lin et al.   VIROLOGICA SINICA

The Capsid Binder Vapendavir and the Novel Protease Inhibitor SG85 Inhibit Enterovirus 71 Replication

(2014) Aloys Tijsma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a

(2014) JaeHyoung Song et al.   Biomolecules & Therapeutics

Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines)

(2014) Min Li-Weber   INTERNATIONAL JOURNAL OF CANCER

Inhibition of Enterovirus 71 by Adenosine Analog NITD008

(2014) C.-L. Deng et al.   JOURNAL OF VIROLOGY

Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity

(2014) K P Callahan et al.   LEUKEMIA

An Inactivated Enterovirus 71 Vaccine in Healthy Children

(2014) Rongcheng Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy, Safety, and Immunogenicity of an Enterovirus 71 Vaccine in China

(2014) Fengcai Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular and physiological actions of quercetin: need for clinical trials to assess its benefits in human disease

(2014) Sarah L Miles et al.   NUTRITION REVIEWS

Resistance to hepatitis C virus protease inhibitors

(2014) Tara L Kieffer et al.   Current Opinion in Virology

Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71

(2014) Minghao Dang et al.   Protein & Cell

A Novel, Broad-Spectrum Inhibitor of Enterovirus Replication That Targets Host Cell Factor Phosphatidylinositol 4-Kinase IIIβ

(2013) Hilde M. van der Schaar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Curing a viral infection by targeting the host: The example of cyclophilin inhibitors

(2013) Kai Lin et al.   ANTIVIRAL RESEARCH

Validation-based insertional mutagenesis for identification of Nup214 as a host factor for EV71 replication in RD cells

(2013) Bei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Milrinone Therapy for Enterovirus 71-Induced Pulmonary Edema and/or Neurogenic Shock in Children

(2013) Chia-Yu Chi et al.   CRITICAL CARE MEDICINE

Phenotypic screens as a renewed approach for drug discovery

(2013) Wei Zheng et al.   DRUG DISCOVERY TODAY

RNA-based mechanisms regulating host-virus interactions

(2013) Rui Zhou et al.   IMMUNOLOGICAL REVIEWS

Chebulagic Acid, a Hydrolyzable Tannin, Exhibited Antiviral Activity in Vitro and in Vivo against Human Enterovirus 71

(2013) Yajun Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug Discovery for Neglected Diseases: Molecular Target-Based and Phenotypic Approaches

(2013) Ian H. Gilbert   JOURNAL OF MEDICINAL CHEMISTRY

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

(2013) J. Tan et al.   JOURNAL OF VIROLOGY

Heat Shock protein 90: Role in Enterovirus 71 Entry and Assembly and Potential Target for Therapy

(2013) Yueh-Liang Tsou et al.   PLoS One

Heat shock protein-90-beta facilitates enterovirus 71 viral particles assembly

(2013) Robert Y.L. Wang et al.   VIROLOGY

Genetic characterization of EV71 isolates from 2004 to 2010 reveals predominance and persistent circulation of the newly proposed genotype D and recent emergence of a distinct lineage of subgenotype C2 in Hong Kong

(2013) Cyril CY Yip et al.   Virology Journal

Targeting the host or the virus: Current and novel concepts for antiviral approaches against influenza virus infection

(2012) Suki Man-Yan Lee et al.   ANTIVIRAL RESEARCH

In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection

(2012) Guofeng Zhang et al.   ARCHIVES OF VIROLOGY

Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo

(2012) Yajun Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Natural Anticancer Compounds Rocaglamides Inhibit the Raf-MEK-ERK Pathway by Targeting Prohibitin 1 and 2

(2012) Gernot Polier et al.   CHEMISTRY & BIOLOGY

Host-targeting agents for prevention and treatment of chronic hepatitis C – Perspectives and challenges

(2012) Mirjam B. Zeisel et al.   JOURNAL OF HEPATOLOGY

Enterovirus 71 VPg Uridylation Uses a Two-Molecular Mechanism of 3D Polymerase

(2012) Y. Sun et al.   JOURNAL OF VIROLOGY

Antiviral Effect of Matrine against Human Enterovirus 71

(2012) Yajun Yang et al.   MOLECULES

A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71

(2012) Xiangxi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo

(2012) Yajun Yang et al.   PHYTOMEDICINE

COPI Is Required for Enterovirus 71 Replication

(2012) Jianmin Wang et al.   PLoS One

High-Affinity Dkk1 Receptor Kremen1 Is Internalized by Clathrin-Mediated Endocytosis

(2012) Sanjay K. Mishra et al.   PLoS One

Combinatorial Approaches to the Prevention and Treatment of HIV-1 Infection

(2011) Vanessa Pirrone et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparative RNAi Screening Reveals Host Factors Involved in Enterovirus Infection of Polarized Endothelial Monolayers

(2011) Carolyn B. Coyne et al.   Cell Host & Microbe

Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin

(2011) Qin-Chang Zhu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins

(2011) Fuu-Jen Tsai et al.   FOOD CHEMISTRY

Comparative proteome analyses of host protein expression in response to Enterovirus 71 and Coxsackievirus A16 infections

(2011) Jia Jun Lee et al.   Journal of Proteomics

Modification of the Untranslated Regions of Human Enterovirus 71 Impairs Growth in a Cell-Specific Manner

(2011) C. C. Kok et al.   JOURNAL OF VIROLOGY

A Non-Mouse-Adapted Enterovirus 71 (EV71) Strain Exhibits Neurotropism, Causing Neurological Manifestations in a Novel Mouse Model of EV71 Infection

(2011) W. X. Khong et al.   JOURNAL OF VIROLOGY

Sustained High Levels of Interleukin-6 Contribute to the Pathogenesis of Enterovirus 71 in a Neonate Mouse Model

(2011) W. X. Khong et al.   JOURNAL OF VIROLOGY

Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication

(2011) Jiangning Liu et al.   Virology Journal

Anti-Human Rhinovirus Activity of Raoulic Acid from Raoulia australis

(2010) Hwa Jung Choi et al.   JOURNAL OF MEDICINAL FOOD

A Novel Population of Myeloid Cells Responding to Coxsackievirus Infection Assists in the Dissemination of Virus within the Neonatal CNS

(2010) J. M. Tabor-Godwin et al.   JOURNAL OF NEUROSCIENCE

Viral Mutation Rates

(2010) R. Sanjuan et al.   JOURNAL OF VIROLOGY

Differential Effects of the Putative GBF1 Inhibitors Golgicide A and AG1478 on Enterovirus Replication

(2010) L. van der Linden et al.   JOURNAL OF VIROLOGY

Virology, epidemiology, pathogenesis, and control of enterovirus 71

(2010) Tom Solomon et al.   LANCET INFECTIOUS DISEASES

Cancer Therapies Utilizing the Camptothecins: A Review of thein VivoLiterature

(2010) Vincent J. Venditto et al.   MOLECULAR PHARMACEUTICS

The cross-reactivity of the enterovirus 71 to human brain tissue and identification of the cross-reactivity related fragments

(2010) Chun Jia et al.   Virology Journal

HIV-1 Entry, Inhibitors, and Resistance

(2010) Michael A. Lobritz et al.   Viruses-Basel

Novel Antiviral Agent DTriP-22 Targets RNA-Dependent RNA Polymerase of Enterovirus 71

(2009) T.-C. Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiviral Effect of Epigallocatechin Gallate on Enterovirus 71

(2009) Hung-Yao Ho et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NF B

(2009) T. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71

(2008) Cheng-Wen Lin et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The molecular basis of mouse adaptation by human enterovirus 71

(2008) B. H. Chua et al.   JOURNAL OF GENERAL VIROLOGY