Journal
DISEASE MODELS & MECHANISMS
Volume 9, Issue 11, Pages 1241-1244Publisher
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dmm.028159
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An increasing number of laboratories that focus on model systems are considering drug screening. Executing a drug screen is complicated enough. But the path for moving initial hits towards the clinic requires a different knowledge base and even a different mindset. In this Editorial I discuss the importance of doing some homework before you start screening. 'Lead hits', 'patentable chemical space' and 'druggability' are all concepts worth exploring when deciding which screening path to take. I discuss some of the lessons I learned that may be useful as you navigate the screening matrix.
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