Article
Virology
Yuhan Liu, Junwei Chen, Ming Zhang, Wei Guo, Changzeng Feng, Jiansheng Liu, Lilan Xu, Na Gao, Shaohui Ma
Summary: This study found that Enterovirus A71 (EV-A71) was the main pathogen associated with HFMD among children in Yunnan, China, followed by Coxsackievirus B4 (CV-B4), Coxsackievirus A16 (CV-A16), Coxsackievirus B5 (CV-B5), and Echovirus 9 (E-9). EV-A and EV-B accounted for 45.1% and 41.3%, respectively. The study also found that CV-B5 and the majority of CV-B4 belonged to genotypes VI and C3, respectively. These results suggest that EV-B, especially CV-Bs, may play important roles in HFMD.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Infectious Diseases
Mei Li, Ya-Ping Li, Hui-Ling Deng, Mu-Qi Wang, Yuan Chen, Yu-Feng Zhang, Jun Wang, Shuang-Suo Dang
Summary: This study investigated the role of IFITM3 in EV71-HFMD and found that the methylation status and SNP genotyping of IFITM3 may help clinicians choose the correct treatment strategy for patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Chih-Yeu Fang, Chia-Chyi Liu
Summary: Hand, foot, and mouth disease poses a serious threat to young children in the Asia-Pacific region, with enterovirus A71 (EV-A71) being a major cause of severe complications. While vaccines exist to prevent EV-A71 infection, there is a lack of effective treatments for other enteroviruses. Novel strategies are needed to develop new therapies for emerging enteroviruses associated with HFMD, including the use of DNA/RNA vaccine technology, structure biology, neutralization antibody studies, and nucleotide aptamer library screening.
EXPERT OPINION ON DRUG DISCOVERY
(2022)
Article
Virology
Lei Zhu, Hong Yin, Tong Qian, Gong-jian Qi, Jin-song Ren, Yin Wang, Bo-xiang Qi
Summary: This study assessed the association between AQP-4 and the severity of EV71-associated HFMD. The study found significant differences in serum AQP-4, IL-6, NE, and NSE levels among the critical, severe, and common groups before and after treatment. Furthermore, serum AQP-4 levels correlated closely with IL-6, NE, and NSE levels.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Zhong Zhang, Yang Liu, Fengfeng Liu, Minrui Ren, Taoran Nie, Jinzhao Cui, Zhaorui Chang, Zhongjie Li
Summary: This study analyzed laboratory-confirmed HFMD outbreaks in mainland China between 2011 to 2018 and found that EV-A71, CV-A16, and CV-A6 are the three most common serotypes causing HFMD, with strong transmission among children.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Virology
Xia Wang, Hong Liu, Ying Li, Rui Su, Yamin Liu, Kunyan Qiao
Summary: The study found that the rs6812193 T allele in the SCARB2 gene may be associated with the severity of EV-71 associated HFMD.
Article
Infectious Diseases
Jiaolian Tang, Zhilei Zhang, Zhen Zhang, Hailing Huang, Tingyi Du, Xiaodan Wang, Lingmei Yan, Qin Rao, Jinghui Yang, Meifeng Wang, Ru Shen, Qiangming Sun, Hongchao Jiang
Summary: The study analyzed the genomic sequences of two rare cases of EVA71 infection following vaccination, finding that amino acid mutations may affect vaccine efficacy.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Jacqueline Farinha Shimizu, Shiraz Feferbaum-Leite, Igor Andrade Santos, Daniel Oliveira Silva Martins, Natalie J. Kingston, Mona Shegdar, Carsten Zothner, Suely Vilela Sampaio, Mark Harris, Nicola J. Stonehouse, Ana Carolina Gomes Jardim
Summary: Enterovirus A71 (EVA71), the main cause of hand, foot, and mouth disease, has no approved antiviral treatment. Proteins isolated from snake venom, such as CM10, CM14, Crotamin, and PLA2CB, have shown potent antiviral activity against EVA71 infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, General & Internal
Jing Sun, Yuanyuan Li, Zhi Yang, Qingfeng Fang, Biquan Chen
Summary: The introduction of EV71 vaccine has led to changes in the epidemiological characteristics and etiology of HFMD patients. The number of cases decreased gradually after vaccination, with significant changes in age distribution. The proportion of cases caused by EV71 and severe cases decreased significantly after vaccination. However, EV71 still remains a major pathogen in severe HFMD cases. There were no significant differences in epidemiological characteristics and enterovirus serotypes between unvaccinated and vaccinated cases.
Article
Plant Sciences
Naixin Kang, Hongwei Gao, Luan He, Yanli Liu, Handong Fan, Qiongming Xu, Shilin Yang
Summary: The study found that Rb1 exhibits strong antiviral activities against EV71 infection in both in vitro and in vivo models, reducing viral damage and enhancing immune responses.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qingyu Yang, Chengyuan Wu, Guangyan Zhu, Fuli Ren, Binbin Lin, Rui Huang, Xujuan Hu, Dingran Zhao, Ke Peng, Qiongya Wang, Chaolin Huang, Dingyu Zhang
Summary: In this study, ML390, a dihydroorotate dehydrogenase inhibitor, was found to have potential anti-EV71 activity. It effectively inhibited viral replication and reduced viral load in infected mice, leading to an increased survival rate. ML390 shows promise for the treatment of hand, foot, and mouth disease caused by EV71 infection.
ANTIVIRAL RESEARCH
(2023)
Article
Microbiology
Oluwatayo Israel Olasunkanmi, Yanru Fei, Juval Avala Ntsigouaye, Ming Yi, Yao Wang, Jinchang Liu, Weixu Cheng, James Megeto, Tahira Bashir, Yang Chen, Weizhen Xu, Lexun Lin, Wenran Zhao, Yan Wang, Zhaohua Zhong
Summary: This study found that trans-2-hexenoic acid (THA), a natural product from a dietary source, has antiviral activity against coxsackievirus B (CVB) and enterovirus A71 (EV-A71), inhibiting viral replication at the entry stage of infection. Since THA has received approval as a food additive, it could serve as a safe therapeutic option for enterovirus infections or pave the way for the production of more antiviral drugs in the future.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Guangyan Zhu, Chengyuan Wu, Qian Wang, Danchun Deng, Binbin Lin, Xujuan Hu, Fang Qiu, Zhengnan Li, Chaolin Huang, Qingyu Yang, Dingyu Zhang
Summary: This study explores the role of HSP90 in EV71 replication and its potential as a target for anti-EV71 agents. It finds that a HSP90 inhibitor, VER50589, can effectively inhibit EV71 replication and also shows activity against other enteroviruses. The antiviral activity of VER50589 is mediated through the regulation of the AKT and RAF/MEK/ERK signaling pathways.
ANTIVIRAL RESEARCH
(2023)
Review
Virology
Subrat Kumar Swain, Subhasmita Panda, Basanta Pravas Sahu, Rachita Sarangi
Summary: This study aims to investigate the interaction between viral ligands and host receptors, the activation of immune-related signaling pathways, and the involvement of cytokines during host-pathogen interaction. The study also examines the roles of viral proteins and interferons.
Article
Multidisciplinary Sciences
Pirom Noisumdaeng, Pilaipan Puthavathana
Summary: This study characterized the molecular evolution of hand, foot and mouth disease (HFMD) viruses in Thailand over a period of twenty years. The findings revealed the co-circulation and subgenotypic changes of the major pathogens causing HFMD outbreaks. The study provided valuable insights into molecular epidemiology and supported the development and implementation of genotype-matched vaccines.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jeongeun Kim, Huijeong Ahn, Sangjung Yu, Jae-Hee Ahn, Hyun-Jeong Ko, Mi-Na Kweon, Eui-Ju Hong, Beum-Soo An, Eunsong Lee, Geun-Shik Lee
Article
Immunology
Jeonghyun Lee, Hyosung Park, Jiwon Lim, Hyung-Seung Jin, Yoon Park, Yu-Jin Jung, Hyun-Jeong Ko, Sung-Il Yoon, Geun-Shik Lee, Pyeung-Hyeun Kim, Sun Shim Choi, Changchun Xiao, Seung Goo Kang
Summary: This study reveals the crucial role of GSK3 in determining the fate of GC B cells towards plasma cell formation, by inducing changes in transcription factors required for plasma cell differentiation. This finding highlights the upstream master regulator responsible for interpreting external cues and mediating the formation of plasma cells in GC B cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Young-In Kim, Eun-Je Yi, Young-Dae Kim, A. Reum Lee, Jiwoung Chung, Hae Chan Ha, Joong Myung Cho, Seong-Ryeol Kim, Hyun-Jeong Ko, Jae-Hee Cheon, Yong Rae Hong, Sun-Young Chang
Summary: The novel drug CG-598 showed significant anti-inflammatory effects in an experimental murine colitis model, enhancing barrier function, reducing inflammatory lesions, and decreasing the expression of pro-inflammatory cytokines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jae-Hee Ahn, Byung-Hyun Lee, Seong-Eun Kim, Bo-Eun Kwon, Hyunjin Jeong, Jong Rip Choi, Min Jung Kim, Yong Park, Byung Soo Kim, Dae Hee Kim, Hyun-Jeong Ko
Summary: Multiple myeloma is a malignant cancer of plasma cells that remains incurable despite recent advancements in treatment. This study suggests that targeting the PD-L1 molecule with an anti-PD-L1 antibody could be a promising strategy for treating multiple myeloma, as it induces antibody-dependent cellular cytotoxicity against myeloma cells.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Virology
Seong-Ryeol Kim, Myeong-Seon Jeong, Seo-Hyeon Mun, Jaewon Cho, Min-Duk Seo, Hyoungsu Kim, Jooeun Lee, Jae-Hyoung Song, Hyun-Jeong Ko
Summary: Chrysin demonstrates potent antiviral activity against A/PR/8 influenza virus by inhibiting viral infection at the early stages of the replication cycle, mainly through activation of mTOR and suppression of autophagy.
Article
Biochemistry & Molecular Biology
Jaewon Cho, Nara Tae, Jae-Hee Ahn, Sun-Young Chang, Hyun-Jeong Ko, Dae Hee Kim
Summary: Chimeric antigen receptor T (CAR-T) cell therapy has shown promising results in treating blood cancer with high overall response rate. However, it has limitations in treating solid tumors and exhibits side effects. Bispecific antibodies have the potential to engage immune cells to target cancer cells and show effective tumor killing activity in vitro and in vivo. Engaging activated T cells with cancer cells using bispecific antibodies could be a novel next generation therapy that inhibits PD-L1 and increases infiltration of activated T cells in tumor site.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Chemistry, Applied
Minyeong Kim, Seong-Ryeol Kim, Jiye Park, Seo-Hyeon Mun, Myounghai Kwak, Hyun-Jeong Ko, Seung-Hoon Baek
Summary: This study aimed to investigate the structure and anti-enterovirus 71 (EV71) effects of polysaccharides extracted from the roots of Sanguisorba officinalis (SO), traditionally used for infectious diseases. The results showed that the purified polysaccharide (S-a3) significantly inhibited cell death and viral gene expression in EV71-infected cells, and alleviated EV71-induced symptoms in a mouse model. The effective dose of S-a3 was non-toxic. This study demonstrates that polysaccharides from SO can be a safe and effective treatment for EV71 infection.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Dong-Gyun Hong, Ga Yeon Song, Cheol Bin Eom, Jae-Hee Ahn, Sun Myoung Kim, Aeri Shim, Yong-Hyun Han, Yoon-Seok Roh, Chang Yeob Han, Eun Ju Bae, Hyun-Jeong Ko, Yoon Mee Yang
Summary: This study reveals the increased expression of ERdj5 in alcoholic liver disease patients and mice. Mice lacking Dnajc10 are more susceptible to alcohol-induced liver injury and hepatic steatosis. Additionally, Dnajc10 depletion worsens oxidative stress and decreases Nrf2 pathway and glutathione contents, providing protection against liver damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Immunology
Young-Saeng Jang, Seok-Won Yang, Tae-Gyu Kim, Ha-Eon Song, Sunhee Park, Eun Hye Lee, Seung-Goo Kang, Sung-il Yoon, Hyun-Jeong Ko, Geun-Shik Lee, Seok-Rae Park, Su Ryeon Seo, Pyeung-Hyeun Kim
Summary: The lactoferrin chimera (LFch) enhances TGF beta 1-induced Foxp3(+) Treg differentiation by diminishing TCR/CD28 signal intensity.
Article
Immunology
Eun-Je Yi, Young -In Kim, Jae-Hyoung Song, Hyun-Jeong Ko, Sun -Young Chang
Summary: Mucosal surfaces play a vital role in protecting the body from infection, and mucosal vaccine delivery is crucial for establishing pathogen-specific mucosal immunity. This study investigates the intranasal administration of curdlan and antigen to induce mucosal immune responses and protect against viral infections. The results show that co-administration of curdlan and antigen increases specific antibodies and induces the differentiation of antigen-specific cells. Furthermore, the combination of curdlan and VP1 provides effective protection against enterovirus infection and reduces tissue damage by promoting Th17 responses.
Article
Biochemistry & Molecular Biology
Hyunjin Jeong, Eun-Hye Hong, Jae-Hee Ahn, Jaewon Cho, Jae-Hyeon Jeong, Chae-Won Kim, Byung-Il Yoon, Ja Hyun Koo, Yun-Yong Park, Yoon Mee Yang, Takao Iwawaki, Bruce A. Vallance, Sun-Young Chang, Hyun-Jeong Ko
Summary: A study on inflammatory bowel disease reveals that an enzyme can protect intestinal goblet cells from cell death during gut inflammation. Modifying the molecular mechanisms of this enzyme could potentially prevent and treat inflammatory bowel disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Suhyun Kim, Eun-Hye Hong, Cheol-Ki Lee, Yiseul Ryu, Hyunjin Jeong, Seungnyeong Heo, Joong-Jae Lee, Hyun-Jeong Ko
Summary: IL-22, a pleiotropic cytokine, shows potential in attenuating and treating colitis. The effective production and purification of recombinant mIL-22 in bacteria demonstrate its ability to ameliorate acute colitis and suppress pro-inflammatory cytokine production.
Article
Immunology
Seong-Ryeol Kim, Jae-Hyoung Song, Jae-Hee Ahn, Myeong Seon Jeong, Yoon Mee Yang, Jaewon Cho, Jae-Hyeon Jeong, Younggil Cha, Kil-Nam Kim, Hong Pyo Kim, Sun-Young Chang, Hyun-Jeong Ko
Summary: This study investigated the association between lipid metabolism and exacerbation of CVB3 pathology using a high-fat diet-induced obese mouse model. The results showed that lipotoxicity-induced inflammation in adipose tissue of obese mice led to increased replication of CVB3 and mortality. Additionally, inhibition of lipid-induced mtROS decreased viral replication. HFD-fed mice were more susceptible to CVB3-induced mortality, but this was ameliorated by administration of the mtROS inhibitor, MitoQ. These findings suggest that mtROS inhibitors could be potential treatments for CVB3 infection.
Article
Oncology
Eun-Hye Hong, Jaewon Cho, Jae-hee Ahn, Bo-Eun Kwon, Mi-Na Kweon, Sang-Uk Seo, Byung-Il Yoon, Sun-Young Chang, Hyun-Jeong Ko
Article
Immunology
Eun-Hye Hong, Jae-Hyoung Song, Seong-Ryeol Kim, Jaewon Cho, Birang Jeong, Heejung Yang, Jae-Hyeon Jeong, Jae-Hee Ahn, Hyunjin Jeong, Seong-Eun Kim, Sun-Young Chang, Hyun-Jeong Ko
