Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells

Peptidyl Aldehyde NK-1.8k Suppresses Enterovirus 71 and Enterovirus 68 Infection by Targeting Protease 3C

(2015) Yaxin Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Allosteric Functional Switch in Poliovirus 3C Protease

(2015) Yan M. Chan et al.   BIOPHYSICAL JOURNAL

Protease 3C of hepatitis A virus induces vacuolization of lysosomal/endosomal organelles and caspase-independent cell death

(2015) Andrey V Shubin et al.   BMC CELL BIOLOGY

Phosphatidylserine Vesicles Enable Efficient En Bloc Transmission of Enteroviruses

(2015) Ying-Han Chen et al.   CELL

Cytoplasmic translocation, aggregation and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis

(2015) G Fung et al.   CELL DEATH AND DIFFERENTIATION

Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease

(2015) Bo-Kyoung Kim et al.   FEBS LETTERS

Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease

(2015) Yangyang Zhai et al.   JOURNAL OF MEDICINAL CHEMISTRY

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection

(2015) Yong Zhang et al.   NATURE IMMUNOLOGY

Viral precursor protein P3 and its processed products perform discrete and essential functions in the poliovirus RNA replication complex

(2015) Allyn Spear et al.   VIROLOGY

Soluble Coxsackievirus B3 3C Protease Inhibitor Prevents Cardiomyopathy in an Experimental Chronic Myocarditis Murine Model

(2015) Byung-Kwan Lim et al.   VIRUS RESEARCH

Picornavirus IRES elements: RNA structure and host protein interactions

(2015) Encarnación Martínez-Salas et al.   VIRUS RESEARCH

Initiation of protein-primed picornavirus RNA synthesis

(2015) Aniko V. Paul et al.   VIRUS RESEARCH

Conformational Ensemble of the Poliovirus 3CD Precursor Observed by MD Simulations and Confirmed by SAXS: A Strategy to Expand the Viral Proteome?

(2015) Ibrahim Moustafa et al.   Viruses-Basel

Structural insights into viral IRES-dependent translation mechanisms

(2015) Gloria Lozano et al.   Current Opinion in Virology

Respiratory virus modulation of host nucleocytoplasmic transport; target for therapeutic intervention?

(2015) Leon Caly et al.   Frontiers in Microbiology

Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus

(2015) Dylan Flather et al.   Frontiers in Microbiology

Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases

(2014) Lonneke van der Linden et al.   ANTIVIRAL RESEARCH

Synthesis and evaluation of 9-deoxy analogues of (−)-thysanone, an inhibitor of HRV 3C protease

(2014) Joo Young Jeong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex

(2014) X. Lei et al.   JOURNAL OF VIROLOGY

Downregulation of MicroRNA miR-526a by Enterovirus Inhibits RIG-I-Dependent Innate Immune Response

(2014) C. Xu et al.   JOURNAL OF VIROLOGY

3Cpro of Foot-and-Mouth Disease Virus Antagonizes the Interferon Signaling Pathway by Blocking STAT1/STAT2 Nuclear Translocation

(2014) Y. Du et al.   JOURNAL OF VIROLOGY

Hepatitis A Virus 3C Protease Cleaves NEMO To Impair Induction of Beta Interferon

(2014) D. Wang et al.   JOURNAL OF VIROLOGY

Enterovirus 71 Inhibits Cellular Type I Interferon Signaling by Downregulating JAK1 Protein Expression

(2014) Ying Liu et al.   VIRAL IMMUNOLOGY

Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication

(2013) Yannick Debing et al.   ANTIVIRAL RESEARCH

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2013)

(2013) M. J. Adams et al.   ARCHIVES OF VIROLOGY

Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus

(2013) Sivakoteswara Rao Mandadapu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors

(2013) Allan M. Prior et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

(2013) J. Tan et al.   JOURNAL OF VIROLOGY

Inhibition of Poliovirus-Induced Cleavage of Cellular Protein PCBP2 Reduces the Levels of Viral RNA Replication

(2013) A. J. Chase et al.   JOURNAL OF VIROLOGY

Foot-and-Mouth Disease Virus 3C Protease Induces Fragmentation of the Golgi Compartment and Blocks Intra-Golgi Transport

(2013) Z. Zhou et al.   JOURNAL OF VIROLOGY

Synthesis of the 2-methylene analogue of the HRV 3C protease inhibitor thysanone (2-carbathysanone)

(2013) Katrin Schünemann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Rhinovirus 3C Protease Facilitates Specific Nucleoporin Cleavage and Mislocalisation of Nuclear Proteins in Infected Host Cells

(2013) Erin J. Walker et al.   PLoS One

Production of a Dominant-Negative Fragment Due to G3BP1 Cleavage Contributes to the Disruption of Mitochondria-Associated Protective Stress Granules during CVB3 Infection

(2013) Gabriel Fung et al.   PLoS One

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

Functional Architecture of the Nuclear Pore Complex

(2012) Einat Grossman et al.   Annual Review of Biophysics

Recent development of 3C and 3CL protease inhibitors for anti-coronavirus and anti-picornavirus drug discovery

(2012) R. Ramajayam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Development of anti-coxsackievirus agents targeting 3C protease

(2012) Bo-Kyoung Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Viral and host factors that contribute to pathogenicity of enterovirus 71

(2012) Hsing-I Huang et al.   Future Microbiology

Autophagy: An Emerging Immunological Paradigm

(2012) V. Deretic   JOURNAL OF IMMUNOLOGY

Fisetin and rutin as 3C protease inhibitors of enterovirus A71

(2012) Ying-Ju Lin et al.   JOURNAL OF VIROLOGICAL METHODS

Cleavage of Interferon Regulatory Factor 7 by Enterovirus 71 3C Suppresses Cellular Responses

(2012) Xiaobo Lei et al.   JOURNAL OF VIROLOGY

Site-Specific Cleavage of the Host Poly(A) Binding Protein by the Encephalomyocarditis Virus 3C Proteinase Stimulates Viral Replication

(2012) M. Kobayashi et al.   JOURNAL OF VIROLOGY

Foot-and-Mouth Disease Virus 3C Protease Cleaves NEMO To Impair Innate Immune Signaling

(2012) D. Wang et al.   JOURNAL OF VIROLOGY

The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells

(2012) Paul Lawrence et al.   VIROLOGY

The Multifaceted Poliovirus 2A Protease: Regulation of Gene Expression by Picornavirus Proteases

(2011) Alfredo Castelló et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Crystal Structure of Human Enterovirus 71 3C Protease

(2011) Sheng Cui et al.   JOURNAL OF MOLECULAR BIOLOGY

Cleavage of the Adaptor Protein TRIF by Enterovirus 71 3C Inhibits Antiviral Responses Mediated by Toll-Like Receptor 3

(2011) X. Lei et al.   JOURNAL OF VIROLOGY

Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues

(2011) J. Wang et al.   JOURNAL OF VIROLOGY

Differential Processing of Nuclear Pore Complex Proteins by Rhinovirus 2A Proteases from Different Species and Serotypes

(2011) K. Watters et al.   JOURNAL OF VIROLOGY

Toll-like receptors: key players in antiviral immunity

(2011) Nicholas Arpaia et al.   Current Opinion in Virology

Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD

(2011) Lin Qu et al.   PLoS Pathogens

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

Foot-and-mouth disease virus leader proteinase inhibits dsRNA-induced type I interferon transcription by decreasing interferon regulatory factor 3/7 in protein levels

(2010) Dang Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Non-covalent inhibitors of rhinovirus 3C protease

(2010) Andrew Baxter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Specific Cleavage of the Nuclear Pore Complex Protein Nup62 by a Viral Protease

(2010) Nogi Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses

(2010) X. Lei et al.   JOURNAL OF VIROLOGY

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Individual and common inhibitors of coronavirus and picornavirus main proteases

(2009) Chih-Jung Kuo et al.   FEBS LETTERS

An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China

(2009) Yong Zhang et al.   JOURNAL OF CLINICAL VIROLOGY

Rhinovirus 3C Protease Can Localize in the Nucleus and Alter Active and Passive Nucleocytoplasmic Transport

(2009) R. Ghildyal et al.   JOURNAL OF VIROLOGY

The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection

(2009) Laura Papon et al.   VIROLOGY

Enterovirus 71 3C Protease Cleaves a Novel Target CstF-64 and Inhibits Cellular Polyadenylation

(2009) Kuo-Feng Weng et al.   PLoS Pathogens

Picornavirus Genome Replication

(2008) Harsh B. Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insights into internal ribosome entry site elements relevant for viral gene expression

(2008) E. Martinez-Salas et al.   JOURNAL OF GENERAL VIROLOGY

Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein

(2008) C. Ricour et al.   JOURNAL OF GENERAL VIROLOGY

Identification of the oriI-Binding Site of Poliovirus 3C Protein by Nuclear Magnetic Resonance Spectroscopy

(2008) C. D. Amero et al.   JOURNAL OF VIROLOGY

Leader-Induced Phosphorylation of Nucleoporins Correlates with Nuclear Trafficking Inhibition by Cardioviruses

(2008) F. W. Porter et al.   JOURNAL OF VIROLOGY

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE

Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases

(2008) Sylvain de Breyne et al.   VIROLOGY

An outbreak of acute hemorrhagic conjunctivitis (AHC) caused by coxsackievirus A24 variant in Pakistan

(2008) Anis Khan et al.   VIRUS RESEARCH