Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

(2019) Guihua Wang et al.   NATURE CELL BIOLOGY

Regulation of Clathrin-Mediated Endocytosis

(2018) Marcel Mettlen et al.   Annual Review of Biochemistry

Mesoscale organization of domains in the plasma membrane – beyond the lipid raft

(2018) Stella M. Lu et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cell-free formation and interactome analysis of caveolae

(2018) WooRam Jung et al.   JOURNAL OF CELL BIOLOGY

Loss of PTEN promotes formation of signaling-capable clathrin-coated pits

(2018) Luciana K. Rosselli-Murai et al.   JOURNAL OF CELL SCIENCE

Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module

(2018) Haibin Wang et al.   MOLECULAR CELL

Catalytic activation of β-arrestin by GPCRs

(2018) Kelsie Eichel et al.   NATURE

Targeting the PI3K pathway in cancer: are we making headway?

(2018) Filip Janku et al.   Nature Reviews Clinical Oncology

The functions and regulation of the PTEN tumour suppressor: new modes and prospects

(2018) Yu-Ru Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Functional characterization of lysosomal interaction of Akt with VRK2

(2018) Noriyuki Hirata et al.   ONCOGENE

Conformational sampling of membranes by Akt controls its activation and inactivation

(2018) Iva Lučić et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular Organization of GPCR Signaling

(2018) Kelsie Eichel et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Single-Molecule Imaging of GPCR Interactions

(2018) Davide Calebiro et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Super Resolution Network Analysis Defines the Molecular Architecture of Caveolae and Caveolin-1 Scaffolds

(2018) Ismail M. Khater et al.   Scientific Reports

Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics

(2018) Divya Murthy et al.   Frontiers in Physiology

Antitumor Immunity Is Controlled by Tetraspanin Proteins

(2018) Fleur Schaper et al.   Frontiers in Immunology

New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

(2018) Klaudia Szymonowicz et al.   Cancers

Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking

(2018) William Critchley et al.   Cells

mTOR complex 1 controls the nuclear localization and function of glycogen synthase kinase 3β

(2018) Stephen J. Bautista et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt

(2018) Shu-Lin Liu et al.   MOLECULAR CELL

A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product

(2018) Brady D. Goulden et al.   JOURNAL OF CELL BIOLOGY

Dorsal ruffles enhance activation of Akt by growth factors

(2018) Sei Yoshida et al.   JOURNAL OF CELL SCIENCE

Phosphoinositide conversion in endocytosis and the endolysosomal system

(2017) Alexander Wallroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases

(2017) Fabian Marc Schmid et al.   JOURNAL OF CELL BIOLOGY

Reciprocal regulation of signaling and endocytosis: Implications for the evolving cancer cell

(2017) Sandra L. Schmid   JOURNAL OF CELL BIOLOGY

Localization of mTORC2 activity inside cells

(2017) Michael Ebner et al.   JOURNAL OF CELL BIOLOGY

Selective regulation of clathrin-mediated epidermal growth factor receptor signaling and endocytosis by phospholipase C and calcium

(2017) Ralph Christian Delos Santos et al.   MOLECULAR BIOLOGY OF THE CELL

INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBC

(2017) Darien E. Reed et al.   MOLECULAR CANCER RESEARCH

PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes

(2017) Michael Ebner et al.   MOLECULAR CELL

PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K

(2017) Mouhannad Malek et al.   MOLECULAR CELL

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome

(2017) Zhong Yao et al.   MOLECULAR CELL

Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic

(2017) Kangmin He et al.   NATURE

Genes and molecular pathways underpinning ciliopathies

(2017) Jeremy F. Reiter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

(2017) Andrea L. Marat et al.   SCIENCE

The Cilium: Cellular Antenna and Central Processing Unit

(2017) Jarema J. Malicki et al.   TRENDS IN CELL BIOLOGY

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

MYO6 Regulates Spatial Organization of Signaling Endosomes Driving AKT Activation and Actin Dynamics

(2017) Thomas A. Masters et al.   Cell Reports

Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways

(2017) et al.   Cancers

Feedback regulation of RTK signaling in development

(2017) Cynthia L. Neben et al.   DEVELOPMENTAL BIOLOGY

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

(2016) Antonio Castro-Castro et al.   Annual Review of Cell and Developmental Biology

The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34

(2016) J. M. Backer   BIOCHEMICAL JOURNAL

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

(2016) Young Chan Chae et al.   CANCER CELL

Mechanisms of ciliogenesis suppression in dividing cells

(2016) Hidemasa Goto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Endocytic control of signaling at the plasma membrane

(2016) Elisa Barbieri et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphorylation‐dependent Akt–Inversin interaction at the basal body of primary cilia

(2016) Futoshi Suizu et al.   EMBO JOURNAL

ErbB receptors and tetraspanins: Casting the net wider

(2016) Fedor Berditchevski et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

(2016) Zuzana Kadlecova et al.   JOURNAL OF CELL BIOLOGY

Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus

(2016) Nadia Jaber et al.   JOURNAL OF CELL SCIENCE

An endosomal tether undergoes an entropic collapse to bring vesicles together

(2016) David H. Murray et al.   NATURE

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation

(2016) K. Eichel et al.   NATURE CELL BIOLOGY

Following the trail of lipids: Signals initiated by PI3K function at multiple cellular membranes

(2016) Adam Naguib   Science Signaling

TORC2 Structure and Function

(2016) Christl Gaubitz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1

(2016) Tomoya Yamaguchi et al.   Nature Communications

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy

(2016) K. Okkenhaug et al.   Cancer Discovery

Following the trail of lipids: Signals initiated by PI3K function at multiple cellular membranes

(2016) Adam Naguib   Science Signaling

Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function

(2016) Stefan Gahbauer et al.   Frontiers in Physiology

Akt/PKB: one kinase, many modifications

(2015) Guillermo Risso et al.   BIOCHEMICAL JOURNAL

Phosphoinositides in endocytosis

(2015) York Posor et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ras nanoclusters: Versatile lipid-based signaling platforms

(2015) Yong Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Charming neighborhoods on the cell surface: Plasma membrane microdomains regulate receptor tyrosine kinase signaling

(2015) Ralph Christian Delos Santos et al.   CELLULAR SIGNALLING

Recycling endosomes

(2015) James R Goldenring   CURRENT OPINION IN CELL BIOLOGY

Crosstalk between Akt/GSK3  signaling and dynamin-1 regulates clathrin-mediated endocytosis

(2015) C. R. Reis et al.   EMBO JOURNAL

Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor

(2015) D. Jang et al.   JOURNAL OF CELL SCIENCE

Ion Channel Engineering: Perspectives and Strategies

(2015) Prakash Subramanyam et al.   JOURNAL OF MOLECULAR BIOLOGY

The novel function of CD82 and its impact on BCL2L12 via AKT/STAT5 signal pathway in acute myelogenous leukemia cells

(2015) C Nishioka et al.   LEUKEMIA

Epidermal growth factor–stimulated Akt phosphorylation requires clathrin or ErbB2 but not receptor endocytosis

(2015) Camilo Garay et al.   MOLECULAR BIOLOGY OF THE CELL

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Beclin 1 regulates growth factor receptor signaling in breast cancer

(2015) R A Rohatgi et al.   ONCOGENE

Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases

(2015) Eleonore Beurel et al.   PHARMACOLOGY & THERAPEUTICS

Ubl4A is required for insulin-induced Akt plasma membrane translocation through promotion of Arp2/3-dependent actin branching

(2015) Yu Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+NIK+signalosome on Rab5+endosomes

(2015) Dan Jane-wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

(2015) Laura Braccini et al.   Nature Communications

INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor

(2015) S. Kofuji et al.   Cancer Discovery

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes

(2015) C. Li Chew et al.   Cancer Discovery

Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways

(2015) Jie Liu et al.   Scientific Reports

Tetraspanins as therapeutic targets in hematological malignancy: a concise review

(2015) Kyle A. Beckwith et al.   Frontiers in Physiology

Phosphorylation of AKT: a Mutational Analysis.

(2015) Jonathan R. Hart et al.   Oncotarget

Integrin-Associated CD151 Drives ErbB2-Evoked Mammary Tumor Onset and Metastasis

(2015) Xinyu Deng et al.   NEOPLASIA

Flotillin depletion affects ErbB protein levels in different human breast cancer cells

(2014) Nagham Asp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Microtubule dynamics regulates Akt signaling via dynactin p150

(2014) Hakryul Jo et al.   CELLULAR SIGNALLING

PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function

(2014) Irene Franco et al.   DEVELOPMENTAL CELL

Classes of phosphoinositide 3-kinases at a glance

(2014) S. Jean et al.   JOURNAL OF CELL SCIENCE

Tetraspanins at a glance

(2014) S. Charrin et al.   JOURNAL OF CELL SCIENCE

PI3K and cancer: lessons, challenges and opportunities

(2014) David A. Fruman et al.   NATURE REVIEWS DRUG DISCOVERY

Role of AKT signaling in DNA repair and clinical response to cancer therapy

(2014) Q. Liu et al.   NEURO-ONCOLOGY

Lysosomal Interaction of Akt with Phafin2: A Critical Step in the Induction of Autophagy

(2014) Mami Matsuda-Lennikov et al.   PLoS One

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Complex Relationship between Ligand Binding and Dimerization in the Epidermal Growth Factor Receptor

(2014) Nicholas J. Bessman et al.   Cell Reports

Flotillins in Receptor Tyrosine Kinase Signaling and Cancer

(2014) Antje Banning et al.   Cells

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

(2013) Parthasarathy Seshacharyulu et al.   CANCER LETTERS

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway

(2013) Ying Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes

(2013) David J. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetraspanin CD63 Promotes Vascular Endothelial Growth Factor Receptor 2-β1 Integrin Complex Formation, Thereby Regulating Activation and Downstream Signaling in Endothelial Cellsin Vitroandin Vivo

(2013) Sònia Tugues et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling inputs to invadopodia and podosomes

(2013) D. Hoshino et al.   JOURNAL OF CELL SCIENCE

Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status

(2013) C. Barcelo et al.   JOURNAL OF CELL SCIENCE

Spatiotemporal Dynamics of Phosphorylation in Lipid Second Messenger Signaling

(2013) Corina E. Antal et al.   MOLECULAR & CELLULAR PROTEOMICS

Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate

(2013) York Posor et al.   NATURE

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

(2013) Tamas Balla   PHYSIOLOGICAL REVIEWS

Molecular determinants of PI3K -mediated activation downstream of G-protein-coupled receptors (GPCRs)

(2013) O. Vadas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

(2013) C. Betz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cycles of Ubiquitination and Deubiquitination Critically Regulate Growth Factor-Mediated Activation of Akt Signaling

(2013) W.-L. Yang et al.   Science Signaling

Lipid Sorting and Multivesicular Endosome Biogenesis

(2013) C. Bissig et al.   Cold Spring Harbor Perspectives in Biology

Endocytosis of Receptor Tyrosine Kinases

(2013) L. K. Goh et al.   Cold Spring Harbor Perspectives in Biology

Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase Signaling

(2013) M. J. Wagner et al.   Cold Spring Harbor Perspectives in Biology

GSK-3 and mitochondria in cancer cells

(2013) Federica Chiara et al.   Frontiers in Oncology

The First Five Seconds in the Life of a Clathrin-Coated Pit

(2012) Emanuele Cocucci et al.   CELL

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Flotillin-1/Reggie-2 Protein Plays Dual Role in Activation of Receptor-tyrosine Kinase/Mitogen-activated Protein Kinase Signaling

(2012) Monia Amaddii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDGFR  signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways

(2012) D. L. Clement et al.   JOURNAL OF CELL SCIENCE

Functions and Regulation of Circular Dorsal Ruffles

(2012) J.-L. Hoon et al.   MOLECULAR AND CELLULAR BIOLOGY

Flotillins as regulators of ErbB2 levels in breast cancer

(2012) S Pust et al.   ONCOGENE

TC10 Is Regulated by Caveolin in 3T3-L1 Adipocytes

(2012) Dave Bridges et al.   PLoS One

Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane

(2012) L. P. Sousa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organization, dynamics, and segregation of Ras nanoclusters in membrane domains

(2012) L. Janosi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of the EGF Transcriptional Response by Endocytic Sorting

(2012) B. Brankatschk et al.   Science Signaling

The PtdIns3P-Binding Protein Phafin 2 Mediates Epidermal Growth Factor Receptor Degradation by Promoting Endosome Fusion

(2012) Nina Marie Pedersen et al.   TRAFFIC

Endosomal crosstalk: meeting points for signaling pathways

(2012) Máté Pálfy et al.   TRENDS IN CELL BIOLOGY

Segregation of PIP2 and PIP3 into distinct nanoscale regions within the plasma membrane

(2012) J. Wang et al.   Biology Open

Mitochondrial Akt-regulated mitochondrial apoptosis signaling in cardiac muscle cells

(2011) Ching-Chieh Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Akt, FoxO and regulation of apoptosis

(2011) Xinbo Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

The Akt kinases: Isoform specificity in metabolism and cancer

(2011) Eva Gonzalez et al.   CELL CYCLE

The insulin receptor substrate (IRS) proteins

(2011) Leslie M. Shaw   CELL CYCLE

mTOR complex 2 signaling and functions

(2011) Won Jun Oh et al.   CELL CYCLE

Phosphatidylserine Binding Is Essential for Plasma Membrane Recruitment and Signaling Function of 3-Phosphoinositide-dependent Kinase-1

(2011) Nathan Lucas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine is a critical modulator for Akt activation

(2011) Bill X. Huang et al.   JOURNAL OF CELL BIOLOGY

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain

(2011) Junya Hasegawa et al.   JOURNAL OF CELL BIOLOGY

Integrins traffic rapidly via circular dorsal ruffles and macropinocytosis during stimulated cell migration

(2011) Zhizhan Gu et al.   JOURNAL OF CELL BIOLOGY

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

(2011) Hideki Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal

(2011) Tuanlao Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Clk2 and B56β Mediate Insulin-Regulated Assembly of the PP2A Phosphatase Holoenzyme Complex on Akt

(2011) Joseph T. Rodgers et al.   MOLECULAR CELL

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis

(2011) T Smirnova et al.   ONCOGENE

Profiling of the Tetraspanin CD151 Web and Conspiracy of CD151/Integrin β1 Complex in the Progression of Hepatocellular Carcinoma

(2011) Ranjan Prasad Devbhandari et al.   PLoS One

PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains

(2011) X. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

(2011) Oscar Vadas et al.   Science Signaling

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

Promiscuous affairs of PKB/AKT isoforms in metabolism

(2011) Simon M. Schultze et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Caveolin-1 is required for vascular endothelial insulin uptake

(2010) Hong Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Ras nanoclusters: Combining digital and analog signaling

(2010) Angus Harding et al.   CELL CYCLE

Directional Cell Migration and Chemotaxis in Wound Healing Response to PDGF-AA are Coordinated by the Primary Cilium in Fibroblasts

(2010) Linda Schneider et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The ESCRT complexes

(2010) James H. Hurley   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Docking proteins

(2010) Tilman Brummer et al.   FEBS Journal

Early Endosomal Antigen 1 (EEA1) Is an Obligate Scaffold for Angiotensin II-induced, PKC-α-dependent Akt Activation in Endosomes

(2010) Rafal Robert Nazarewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isoform-specific Regulation of Akt Signaling by the Endosomal Protein WDFY2

(2010) Helena A. Walz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Adipocyte Differentiation by Distinct Subcellular Pools of Protein Kinase B (PKB/Akt)

(2010) Tamara Maiuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dorsal Ruffle Microdomains Potentiate Met Receptor Tyrosine Kinase Signaling and Down-regulation

(2010) Jasmine V. Abella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics

(2010) Fubito Nakatsu et al.   JOURNAL OF CELL BIOLOGY

Role of TI-VAMP and CD82 in EGFR cell-surface dynamics and signaling

(2010) L. Danglot et al.   JOURNAL OF CELL SCIENCE

The Actin-Bundling Protein Palladin Is an Akt1-Specific Substrate that Regulates Breast Cancer Cell Migration

(2010) Y. Rebecca Chin et al.   MOLECULAR CELL

The endocytic matrix

(2010) Giorgio Scita et al.   NATURE

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Akt isoforms are present at distinct subcellular locations

(2009) Stacey A. Santi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility

(2009) Sen-itiroh Hakomori   FEBS LETTERS

DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif

(2009) Jongsun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ClipR-59 Interacts with Akt and Regulates Akt Cellular Compartmentalization

(2009) J. Ding et al.   MOLECULAR AND CELLULAR BIOLOGY

Endocytic Accessory Proteins Are Functionally Distinguished by Their Differential Effects on the Maturation of Clathrin-coated Pits

(2009) Marcel Mettlen et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling

(2009) E. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

(2009) María Yáñez-Mó et al.   TRENDS IN CELL BIOLOGY

Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition

(2009) Véronique Calleja et al.   PLOS BIOLOGY

Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

(2008) Eric Hajduch et al.   BIOCHEMICAL JOURNAL

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

(2008) Noriko Gotoh   CANCER SCIENCE

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

(2008) Michelle M. Hill et al.   CELL

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Endocytosis and intracellular trafficking of ErbBs

(2008) Alexander Sorkin et al.   EXPERIMENTAL CELL RESEARCH

Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer

(2008) Kirstine Roepstorff et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells

(2008) Yoko Murayama et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Internalization of EGF receptor following lipid rafts disruption in keratinocytes is delayed and dependent on p38 MAPK activation

(2008) Sylviane Lambert et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Forkhead Transcription Factor FOXO3a Increases Phosphoinositide-3 Kinase/Akt Activity in Drug-Resistant Leukemic Cells through Induction of PIK3CA Expression

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