Glycosylation in the Tumor Microenvironment: Implications for Tumor Angiogenesis and Metastasis

Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors

(2018) Cecilia Lopez Sambrooks et al.   CANCER RESEARCH

Oligosaccharyltransferase inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity

(2018) Marta Baro et al.   CLINICAL CANCER RESEARCH

The α1,3-fucosyltransferase FUT7 regulates IL-1β-induced monocyte-endothelial adhesion via fucosylation of endomucin

(2018) Jun Zhang et al.   LIFE SCIENCES

Inhibition of fucosylation in human invasive ductal carcinoma reduces E-selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation

(2018) Mylène A. Carrascal et al.   Molecular Oncology

Glycosylation controls cooperative PECAM-VEGFR2-β3 integrin functions at the endothelial surface for tumor angiogenesis

(2018) Rie Imamaki et al.   ONCOGENE

Selectins in cancer immunity

(2017) Lubor Borsig   GLYCOBIOLOGY

Contribution of vascular endothelial growth factor receptor-2 sialylation to the process of angiogenesis

(2017) P Chiodelli et al.   ONCOGENE

Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins

(2017) Ida Signe Bohse Larsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of protein glycosylation in cancer metastasis

(2017) Leticia Oliveira-Ferrer et al.   SEMINARS IN CANCER BIOLOGY

Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling

(2017) Cindy Park-Windhol et al.   Scientific Reports

Targeting tumor multicellular aggregation through IGPR-1 inhibits colon cancer growth and improves chemotherapy

(2017) N Woolf et al.   Oncogenesis

Inhibition of fucosylation by 2-fluorofucose suppresses human liver cancer HepG2 cell proliferation and migration as well as tumor formation

(2017) Ying Zhou et al.   Scientific Reports

Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

(2016) Anna Rita Cantelmo et al.   CANCER CELL

The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype

(2016) Matthew J. Schultz et al.   CANCER RESEARCH

Mechanisms of heparanase inhibitors in cancer therapy

(2016) Benjamin Heyman et al.   EXPERIMENTAL HEMATOLOGY

The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediatedTransHomophilic Interactions and Endothelial Cell Barrier Function

(2016) Panida Lertkiatmongkol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation

(2016) Miguel C. Lucena et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IGPR-1 Is Required for Endothelial Cell–Cell Adhesion and Barrier Function

(2016) Yun Hwa Walter Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Specific N-Glycosylation of Endothelial Cell Receptor Tyrosine Kinase VEGFR-2

(2016) Kevin Brown Chandler et al.   JOURNAL OF PROTEOME RESEARCH

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

(2016) Cecilia Lopez-Sambrooks et al.   Nature Chemical Biology

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Glycolytic regulation of cell rearrangement in angiogenesis

(2016) Bert Cruys et al.   Nature Communications

The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis

(2016) W. Liang et al.   Cancer Immunology Research

Role of Cytokine-Induced Glycosylation Changes in Regulating Cell Interactions and Cell Signaling in Inflammatory Diseases and Cancer

(2016) Justine Dewald et al.   Cells

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways

(2016) Michael C. Ryczko et al.   Scientific Reports

Structural basis for PECAM-1 homophilic binding

(2015) C. Paddock et al.   BLOOD

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

A little sugar goes a long way: The cell biology of O-GlcNAc

(2015) Michelle R. Bond et al.   JOURNAL OF CELL BIOLOGY

HIF2α signaling inhibits adherens junctional disruption in acute lung injury

(2015) Haixia Gong et al.   JOURNAL OF CLINICAL INVESTIGATION

The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF165-induced angiogenesis

(2015) Nathan Beckouche et al.   Science Signaling

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

(2015) Anna Kuchnio et al.   Cell Reports

The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF165-induced angiogenesis

(2015) Nathan Beckouche et al.   Science Signaling

The Fucosylation Inhibitor, 2-Fluorofucose, Inhibits Vaso-Occlusion, Leukocyte-Endothelium Interactions and NF-ĸB Activation in Transgenic Sickle Mice

(2015) John D. Belcher et al.   PLoS One

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma

(2014) S. V. Glavey et al.   BLOOD

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Sweet role of platelet endothelial cell adhesion molecule in understanding angiogenesis

(2014) S. Kitazume et al.   GLYCOBIOLOGY

Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment

(2014) D. O. Croci et al.   GLYCOBIOLOGY

Protein N-glycosylation in oral cancer: Dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling

(2014) X. Varelas et al.   GLYCOBIOLOGY

Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism

(2014) Anas M Abdel Rahman et al.   GLYCOBIOLOGY

Interaction of Platelet Endothelial Cell Adhesion Molecule (PECAM) with α2,6-Sialylated Glycan Regulates Its Cell Surface Residency and Anti-apoptotic Role

(2014) Shinobu Kitazume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NEU1 Sialidase Regulates the Sialylation State of CD31 and Disrupts CD31-driven Capillary-like Tube Formation in Human Lung Microvascular Endothelia

(2014) Chunsik Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a high-mannose ICAM-1 glycoform: effects of ICAM-1 hypoglycosylation on monocyte adhesion and outside in signaling

(2013) David W. Scott et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Endothelial heterogeneity and adhesion molecules N-glycosylation: Implications in leukocyte trafficking in inflammation

(2013) D. W. Scott et al.   GLYCOBIOLOGY

Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis

(2013) Joseph W. Franses et al.   INTERNATIONAL JOURNAL OF CANCER

Development of orally active inhibitors of protein and cellular fucosylation

(2013) N. M. Okeley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterogenic Endothelial Responses to Inflammation: Role for Differential N ‐Glycosylation and Vascular Bed of Origin

(2013) David W. Scott et al.   Journal of the American Heart Association

TNF regulates sialyl-Lewisx and 6-sulfo-sialyl-Lewisx expression in human lung through up-regulation of ST3GAL4 transcript isoform BX

(2012) Florent Colomb et al.   BIOCHIMIE

Endothelial cell metabolism and implications for cancer therapy

(2012) U Harjes et al.   BRITISH JOURNAL OF CANCER

Gene-Targeting of Phd2 Improves Tumor Response to Chemotherapy and Prevents Side-Toxicity

(2012) Rodrigo Leite de Oliveira et al.   CANCER CELL

Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success

(2012) Cristina Branco-Price et al.   CANCER CELL

Definition of Molecular Determinants of Prostate Cancer Cell Bone Extravasation

(2012) S. R. Barthel et al.   CANCER RESEARCH

Critical Role ofO-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

(2012) Thomas P. Lynch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

(2012) Nicolas Skuli et al.   JOURNAL OF CLINICAL INVESTIGATION

Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi’s sarcoma

(2012) Diego O. Croci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis

(2012) Nader Rahimi et al.   MOLECULAR BIOLOGY OF THE CELL

Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin

(2011) Paola Chiodelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Interactions between endothelial selectins and cancer cells regulate metastasis

(2011) Catherine A. et al.   Frontiers in Bioscience-Landmark

Endothelial SurfaceN-Glycans Mediate Monocyte Adhesion and Are Targets for Anti-inflammatory Effects of Peroxisome Proliferator-activated Receptor γ Ligands

(2011) Balu K. Chacko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 Protein Modulates Cell Surface Expression and Activation of Vascular Endothelial Growth Factor Receptor 2 in Human Endothelial Cells

(2011) Anna I. Markowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Tumor angiogenesis: molecular pathways and therapeutic targets

(2011) Sara M Weis et al.   NATURE MEDICINE

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Normalization of the Vasculature for Treatment of Cancer and Other Diseases

(2011) Shom Goel et al.   PHYSIOLOGICAL REVIEWS

Hyaluronan Deficiency in Tumor Stroma Impairs Macrophage Trafficking and Tumor Neovascularization

(2010) N. Kobayashi et al.   CANCER RESEARCH

Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions

(2010) Mihai Nita-Lazar et al.   EXPERIMENTAL CELL RESEARCH

α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling

(2010) Shinobu Kitazume et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability

(2010) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

(2010) Ken D. Johnstone et al.   JOURNAL OF MEDICINAL CHEMISTRY

The glycan profile of endothelial cells in the present of tumor-conditioned medium and potential roles of β-1,6-GlcNAc branching on HUVEC conformation

(2010) Yunli Peng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Cell surface sialic acid inhibits Cx43 gap junction functions in constructed Hela cancer cells involving in sialylated N-cadherin

(2010) Jing Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Endothelial deletion of hypoxia-inducible factor-2  (HIF-2 ) alters vascular function and tumor angiogenesis

(2009) N. Skuli et al.   BLOOD

Why are tumour blood vessels abnormal and why is it important to know?

(2009) J A Nagy et al.   BRITISH JOURNAL OF CANCER

Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface

(2009) Q. Zhao et al.   CANCER RESEARCH

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Glycosylation in immune cell trafficking

(2009) Markus Sperandio et al.   IMMUNOLOGICAL REVIEWS

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking

(2009) S. R. Barthel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive Regulation at the Cell Surface byN-Glycosylation

(2009) James W. Dennis et al.   TRAFFIC

Protein Modification by O-Linked GlcNAc Reduces Angiogenesis by Inhibiting Akt Activity in Endothelial Cells

(2008) Bai Luo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisxepitopes in the human bronchial mucosa

(2008) Sophie Groux-Degroote et al.   BIOCHEMICAL JOURNAL

Inhibition of N-Linked Glycosylation Disrupts Receptor Tyrosine Kinase Signaling in Tumor Cells

(2008) J. N. Contessa et al.   CANCER RESEARCH

N-Glycans in cancer progression

(2008) K. S Lau et al.   GLYCOBIOLOGY

Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin

(2008) S. R Barthel et al.   GLYCOBIOLOGY