Protein N-glycosylation in oral cancer: Dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours

(2013) Peter Wend et al.   EMBO JOURNAL

N-Glycosylation Induces the CTHRC1 Protein and Drives Oral Cancer Cell Migration

(2013) Gangli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding to F-actin guides cadherin cluster assembly, stability, and movement

(2013) Soonjin Hong et al.   JOURNAL OF CELL BIOLOGY

Mechanosensitive systems at the cadherin-F-actin interface

(2013) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Tunicamycin Potentiates Cisplatin Anticancer Efficacy through the DPAGT1/Akt/ABCG2 Pathway in Mouse Xenograft Models of Human Hepatocellular Carcinoma

(2013) H. Hou et al.   MOLECULAR CANCER THERAPEUTICS

Frequent Mutation of the PI3K Pathway in Head and Neck Cancer Defines Predictive Biomarkers

(2013) V. W. Y. Lui et al.   Cancer Discovery

TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor

(2012) Young-Woong Kim et al.   BIOCHEMICAL JOURNAL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

CTHRC1is upregulated by promoter demethylation and transforming growth factor-β1 and may be associated with metastasis in human gastric cancer

(2012) Ping Wang et al.   CANCER SCIENCE

Collagen triple helix repeat containing-1 promotes pancreatic cancer progression by regulating migration and adhesion of tumor cells

(2012) Eun Hye Park et al.   CARCINOGENESIS

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Gene identification in the congenital disorders of glycosylation type I by whole-exome sequencing

(2012) Sharita Timal et al.   HUMAN MOLECULAR GENETICS

Transcriptional Regulation of the Protocadherin β Cluster during Her-2 Protein-induced Mammary Tumorigenesis Results from AlteredN-Glycan Branching

(2012) Huabei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of β-Catenin-mediated Transcriptional Regulation of Epidermal Growth Factor Receptor Expression in Glycogen Synthase Kinase 3 β-inactivated Prostate Cancer Cells

(2012) Kiran Kumar Naidu Guturi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion

(2012) P. K. Sengupta et al.   JOURNAL OF CELL SCIENCE

N-glycosylation alters cadherin-mediated intercellular binding kinetics

(2012) M. D. Langer et al.   JOURNAL OF CELL SCIENCE

N-glycan biosynthesis inhibitors induce in vitro anticancer activity in colorectal cancer cells

(2012) Julio Cesar Madureira de-Freitas-Junior et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The molecular pathogenesis of head and neck squamous cell carcinoma

(2012) S. Michael Rothenberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Aberrant amplification of the crosstalk between canonical Wnt signaling and N-glycosylation gene DPAGT1 promotes oral cancer

(2012) Basem Jamal et al.   ORAL ONCOLOGY

Loss and Recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation Is a Mechanism Involved in Epithelial-Mesenchymal-Epithelial Transitions

(2012) Salomé S. Pinho et al.   PLoS One

Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression

(2012) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vinculin-dependent Cadherin mechanosensing regulates efficient epithelial barrier formation

(2012) F. Twiss et al.   Biology Open

Mest/Peg1 inhibits Wnt signalling through regulation of LRP6 glycosylation

(2011) Hwajin Jung et al.   BIOCHEMICAL JOURNAL

Protein kinase Cζ phosphorylates occludin and promotes assembly of epithelial tight junctions

(2011) Suneet Jain et al.   BIOCHEMICAL JOURNAL

Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells

(2011) Vlad C. Sandulache et al.   CANCER

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Disruptive TP53 Mutation Is Associated with Aggressive Disease Characteristics in an Orthotopic Murine Model of Oral Tongue Cancer

(2011) D. Sano et al.   CLINICAL CANCER RESEARCH

Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53

(2011) Joanna Zawacka-Pankau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The secret life of α-catenin: Moonlighting in morphogenesis

(2011) Stephanie L. Maiden et al.   JOURNAL OF CELL BIOLOGY

Downregulation of E-Cadherin enhances proliferation of head and neck cancer through transcriptional regulation of EGFR

(2011) Dongsheng Wang et al.   Molecular Cancer

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Hypoglycosylated E-cadherin promotes the assembly of tight junctions through the recruitment of PP2A to adherens junctions

(2010) Mihai Nita-Lazar et al.   EXPERIMENTAL CELL RESEARCH

Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma

(2010) Andre Cassell et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

N-Glycosylation GeneDPAGT1Is a Target of the Wnt/β-Catenin Signaling Pathway

(2010) Pritam K. Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt/β-Catenin Signaling Down-regulatesN-Acetylglucosaminyltransferase III Expression

(2010) Qingsong Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II–dependent manner

(2010) Quint le Duc et al.   JOURNAL OF CELL BIOLOGY

Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer

(2010) Chien-Hsing Lee et al.   Molecular Cancer

Roles of Fibroblast Growth Factor Receptors in Carcinogenesis

(2010) E. M. Haugsten et al.   MOLECULAR CANCER RESEARCH

Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation

(2010) S E Wheeler et al.   ONCOGENE

Specific posttranslational modification regulates early events in mammary carcinoma formation

(2010) H.-B. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt signaling in stem and cancer stem cells

(2010) Peter Wend et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Activation of ER stress and inhibition of EGFR N-glycosylation by tunicamycin enhances susceptibility of human non-small cell lung cancer cells to erlotinib

(2009) Yi-He Ling et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Overexpression of DPAGT1 Leads to Aberrant N-Glycosylation of E-Cadherin and Cellular Discohesion in Oral Cancer

(2009) M. Nita-Lazar et al.   CANCER RESEARCH

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

Structure, Expression, and Regulation of UDP-GlcNAc: Dolichol Phosphate GlcNAc-1-Phosphate Transferase (DPAGT1)

(2009) Roger Bretthauer   CURRENT DRUG TARGETS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

(2009) S. S. Pinho et al.   HUMAN MOLECULAR GENETICS

Regulation of Homotypic Cell-Cell Adhesion by BranchedN-Glycosylation of N-cadherin Extracellular EC2 and EC3 Domains

(2009) Hua-Bei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity of the β-catenin phosphodestruction complex at cell–cell contacts is enhanced by cadherin-based adhesion

(2009) Meghan T. Maher et al.   JOURNAL OF CELL BIOLOGY

Cell polarity triggered by cell-cell adhesion via E-cadherin

(2009) R. A. Desai et al.   JOURNAL OF CELL SCIENCE

Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy

(2009) S. Choi et al.   JOURNAL OF DENTAL RESEARCH

Cadherin-Bound β-Catenin Feeds into the Wnt Pathway upon Adherens Junctions Dissociation: Evidence for an Intersection between β-Catenin Pools

(2009) Yoonseok Kam et al.   PLoS One

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines

(2008) Sasha H. Anagnostou et al.   BIOCHEMICAL JOURNAL

Epithelial to mesenchymal transition in head and neck squamous carcinoma

(2008) Mahitosh Mandal et al.   CANCER

Inhibition of N-Linked Glycosylation Disrupts Receptor Tyrosine Kinase Signaling in Tumor Cells

(2008) J. N. Contessa et al.   CANCER RESEARCH

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Cthrc1 Selectively Activates the Planar Cell Polarity Pathway of Wnt Signaling by Stabilizing the Wnt-Receptor Complex

(2008) Shinji Yamamoto et al.   DEVELOPMENTAL CELL

N-Glycans in cancer progression

(2008) K. S Lau et al.   GLYCOBIOLOGY

The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors

(2008) Hiroshi Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton

(2007) Andrea Hartsock et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES