Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins

(2014) Natalia A. Cherepanova et al.   JOURNAL OF CELL BIOLOGY

The cellular thermal shift assay for evaluating drug target interactions in cells

(2014) Rozbeh Jafari et al.   Nature Protocols

Structural Basis of Substrate Specificity of Human Oligosaccharyl Transferase Subunit N33/Tusc3 and Its Role in Regulating Protein N-Glycosylation

(2014) Elisabeth Mohorko et al.   STRUCTURE

High-throughput Screening Identifies Aclacinomycin as a Radiosensitizer of EGFR-Mutant Non-Small Cell Lung Cancer

(2014) Daniel C Bennett et al.   Translational Oncology

Structure of the mammalian oligosaccharyl-transferase complex in the native ER protein translocon

(2014) Stefan Pfeffer et al.   Nature Communications

N-linked protein glycosylation in the ER

(2013) Markus Aebi   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glycoprotein Biosynthesis in a Eukaryote Lacking the Membrane Protein Rft1

(2013) Jennifer Jelk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST

(2013) Shiteshu Shrimal et al.   JOURNAL OF CELL BIOLOGY

Glycosylation of closely spaced acceptor sites in human glycoproteins

(2013) S. Shrimal et al.   JOURNAL OF CELL SCIENCE

The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation

(2012) P. Roboti et al.   JOURNAL OF CELL SCIENCE

Mechanisms and principles of N-linked protein glycosylation

(2011) Flavio Schwarz et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Successful prenatal mannose treatment for congenital disorder of glycosylation-Ia in mice

(2011) Anette Schneider et al.   NATURE MEDICINE

Precision Mapping of an In Vivo N-Glycoproteome Reveals Rigid Topological and Sequence Constraints

(2010) Dorota F. Zielinska et al.   CELL

Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis Is a Novel Target for Cancer Therapy

(2010) J. N. Contessa et al.   CLINICAL CANCER RESEARCH

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

(2010) D. S. Auld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

(2010) J. Weiss et al.   Science Translational Medicine

Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms

(2009) Catalina Ruiz-Canada et al.   CELL

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

Src Promotes Survival and Invasion of Lung Cancers with Epidermal Growth Factor Receptor Abnormalities and Is a Potential Candidate for Molecular-Targeted Therapy

(2009) E. L.-H. Leung et al.   MOLECULAR CANCER RESEARCH

Oncogene Addiction

(2008) I. B. Weinstein et al.   CANCER RESEARCH

Does Rft1 flip an N-glycan lipid precursor?

(2008) Christian G. Frank et al.   NATURE