Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury

Neuregulin-1 positively modulates glial response and improves neurological recovery following traumatic spinal cord injury

(2017) Arsalan Alizadeh et al.   GLIA

Anti-inflammatory and immunomodulatory mechanisms of atorvastatin in a murine model of traumatic brain injury

(2017) Xin Xu et al.   Journal of Neuroinflammation

Insights into the Dual Role of Inflammation after Spinal Cord Injury

(2017) Ruslan Rust et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

(2017) Ilse Bollaerts et al.   MEDIATORS OF INFLAMMATION

Mevalonate Cascade and Small Rho GTPase in Spinal Cord Injury

(2017) Qi Chen et al.   Current Molecular Pharmacology

Low-level laser facilitates alternatively activated macrophage/microglia polarization and promotes functional recovery after crush spinal cord injury in rats

(2017) Ji Wei Song et al.   Scientific Reports

Conditional Sox9 ablation improves locomotor recovery after spinal cord injury by increasing reactive sprouting

(2016) William M. McKillop et al.   EXPERIMENTAL NEUROLOGY

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

(2016) Michael B. Keough et al.   Nature Communications

Two PTP receptors mediate CSPG inhibition by convergent and divergent signaling pathways in neurons

(2016) Yosuke Ohtake et al.   Scientific Reports

Adoptive transfer of M2 macrophages promotes locomotor recovery in adult rats after spinal cord injury

(2015) Shan-Feng Ma et al.   BRAIN BEHAVIOR AND IMMUNITY

Chondroitin sulfate proteoglycans: Key modulators in the developing and pathologic central nervous system

(2015) Scott M. Dyck et al.   EXPERIMENTAL NEUROLOGY

Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK Pathway

(2015) Scott M. Dyck et al.   STEM CELLS

Functional regeneration beyond the glial scar

(2014) Jared M. Cregg et al.   EXPERIMENTAL NEUROLOGY

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

Neutrophil contribution to spinal cord injury and repair

(2014) Virginie Neirinckx et al.   Journal of Neuroinflammation

Regulation of IL-10 by Chondroitinase ABC Promotes a Distinct Immune Response following Spinal Cord Injury

(2014) Athanasios Didangelos et al.   JOURNAL OF NEUROSCIENCE

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

(2014) K. Bartus et al.   JOURNAL OF NEUROSCIENCE

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Dysregulation of the neuregulin-1-ErbB network modulates endogenous oligodendrocyte differentiation and preservation after spinal cord injury

(2013) Marie-Krystel Gauthier et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chondroitin sulfate proteoglycans inhibit oligodendrocyte myelination through PTPσ

(2013) James C. Pendleton et al.   EXPERIMENTAL NEUROLOGY

Analysis of Recruitment and Outcomes in the Phase I/IIa Cethrin Clinical Trial for Acute Spinal Cord Injury

(2013) Lisa McKerracher et al.   JOURNAL OF NEUROTRAUMA

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury

(2013) Kosei Takeuchi et al.   Nature Communications

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

(2012) Lorraine W. Lau et al.   ANNALS OF NEUROLOGY

ConditionalSox9ablation reduces chondroitin sulfate proteoglycan levels and improves motor function following spinal cord injury

(2012) William M. McKillop et al.   GLIA

Cross-talk between neural stem cells and immune cells: the key to better brain repair?

(2012) Zaal Kokaia et al.   NATURE NEUROSCIENCE

NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans

(2012) Travis L Dickendesher et al.   NATURE NEUROSCIENCE

Chondroitinase and Growth Factors Enhance Activation and Oligodendrocyte Differentiation of Endogenous Neural Precursor Cells after Spinal Cord Injury

(2012) Soheila Karimi-Abdolrezaee et al.   PLoS One

IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury

(2011) Junghee Kang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leukocyte Common Antigen-Related Phosphatase Is a Functional Receptor for Chondroitin Sulfate Proteoglycan Axon Growth Inhibitors

(2011) D. Fisher et al.   JOURNAL OF NEUROSCIENCE

A Phase I/IIa Clinical Trial of a Recombinant Rho Protein Antagonist in Acute Spinal Cord Injury

(2011) Michael G. Fehlings et al.   JOURNAL OF NEUROTRAUMA

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

Role of Matrix Metalloproteinases and Therapeutic Benefits of Their Inhibition in Spinal Cord Injury

(2011) Haoqian Zhang et al.   Neurotherapeutics

Activated Microglia Inhibit Axonal Growth through RGMa

(2011) Mari Kitayama et al.   PLoS One

Synergistic Effects of Transplanted Adult Neural Stem/Progenitor Cells, Chondroitinase, and Growth Factors Promote Functional Repair and Plasticity of the Chronically Injured Spinal Cord

(2010) S. Karimi-Abdolrezaee et al.   JOURNAL OF NEUROSCIENCE

Rho-Associated Kinase II (ROCKII) Limits Axonal Growth after Trauma within the Adult Mouse Spinal Cord

(2009) P. Duffy et al.   JOURNAL OF NEUROSCIENCE

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

PTP  Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

(2009) Y. Shen et al.   SCIENCE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

Microglial cell migration stimulated by ATP and C5a involve distinct molecular mechanisms: Quantification of migration by a novel near-infrared method

(2008) Aaron M. Miller et al.   GLIA

Chondroitinase ABC-Mediated Plasticity of Spinal Sensory Function

(2008) W. B. J. Cafferty et al.   JOURNAL OF NEUROSCIENCE

Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

(2008) Asya Rolls et al.   PLOS MEDICINE