Anti-double Stranded DNA Antibodies: Origin, Pathogenicity, and Targeted Therapies
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Anti-double Stranded DNA Antibodies: Origin, Pathogenicity, and Targeted Therapies
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 10, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-07-17
DOI
10.3389/fimmu.2019.01667
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper 2 Responses
- (2018) Stefan Schülke Frontiers in Immunology
- Up-Regulation of TLR7-Mediated IFN-α Production by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus Erythematosus
- (2018) Kei Sakata et al. Frontiers in Immunology
- Overexpression of toll-like receptor 9 correlates with podocyte injury in a murine model of autoimmune membranoproliferative glomerulonephritis
- (2018) Md. Abdul Masum et al. AUTOIMMUNITY
- IL-10 producing CD8+ CD122+ PD-1+ regulatory T cells are expanded by dendritic cells silenced for Allograft Inflammatory Factor-1
- (2018) Diana M. Elizondo et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype
- (2017) Javiera Obreque et al. IMMUNOLOGY
- The deposition of anti-DNA IgG contributes to the development of cutaneous lupus erythematosus
- (2017) Yingying Dong et al. IMMUNOLOGY LETTERS
- Selectivity of Human TLR9 for Double CpG Motifs and Implications for the Recognition of Genomic DNA
- (2017) Jelka Pohar et al. JOURNAL OF IMMUNOLOGY
- Heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) function as endocytic receptors for an internalizing anti-nucleic acid antibody
- (2017) Hyunjoon Park et al. Scientific Reports
- Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
- (2017) Gabrielle McDonald et al. Frontiers in Immunology
- TWEAK/Fn14 Activation Participates in Ro52-Mediated Photosensitization in Cutaneous Lupus Erythematosus
- (2017) Yale Liu et al. Frontiers in Immunology
- Anti-Double-Stranded DNA IgG Participates in Renal Fibrosis through Suppressing the Suppressor of Cytokine Signaling 1 Signals
- (2017) Ping Wang et al. Frontiers in Immunology
- Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8
- (2017) Pattarin Tangtanatakul et al. Scientific Reports
- Flow-Induced Dispersion Analysis for Probing Anti-dsDNA Antibody Binding Heterogeneity in Systemic Lupus Erythematosus Patients: Toward a New Approach for Diagnosis and Patient Stratification
- (2016) Nicklas N. Poulsen et al. ANALYTICAL CHEMISTRY
- The role of monogamous bivalency and Fc interactions in the binding of anti-DNA antibodies to DNA antigen
- (2016) Nancy A. Stearns et al. CLINICAL IMMUNOLOGY
- The features of skin inflammation induced by lupus serum
- (2016) Lena Liu et al. CLINICAL IMMUNOLOGY
- Binding of anti-dsDNA antibodies to proximal tubular epithelial cells contributes to renal tubulointerstitial inflammation
- (2016) S. Yung et al. CLINICAL SCIENCE
- The Alarmin Properties of DNA and DNA-associated Nuclear Proteins
- (2016) Melinda Magna et al. CLINICAL THERAPEUTICS
- Phosphoinositide 3-kinase/protein kinase B/periostin mediated platelet-derived growth factor-induced cell proliferation and extracellular matrix production in lupus nephritis
- (2016) Xue Zhao et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Current trends in autoimmunity and the nervous system
- (2016) Carlo Selmi et al. JOURNAL OF AUTOIMMUNITY
- An anti-DNA antibody prefers damaged dsDNA over native
- (2016) N.I. Akberova et al. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
- Amending HIV Drugs: A Novel Small-Molecule Approach To Target Lupus Anti-DNA Antibodies
- (2016) Sonya VanPatten et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway
- (2016) Zhiqin Liu et al. MEDIATORS OF INFLAMMATION
- Anti-DNA antibody mediated catalysis is isotype dependent
- (2016) Yumin Xia et al. MOLECULAR IMMUNOLOGY
- Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
- (2016) Qi Chen et al. NATURE IMMUNOLOGY
- Epithelial-mesenchymal transition in pediatric nephropathies
- (2016) Laura Penna Rocha et al. PATHOLOGY RESEARCH AND PRACTICE
- Systemic lupus erythematosus biomarkers: the challenging quest
- (2016) Cristina Arriens et al. RHEUMATOLOGY
- Ig Constant Region Effects on Variable Region Structure and Function
- (2016) Alena Janda et al. Frontiers in Microbiology
- Distinct effects of mycophenolate mofetil and cyclophosphamide on renal fibrosis in NZBWF1/J mice
- (2015) Susan Yung et al. AUTOIMMUNITY
- A peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigens
- (2015) Y. Xia et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Cell death induced by endoplasmic reticulum stress
- (2015) Raffaella Iurlaro et al. FEBS Journal
- DNA-histone complexes as ligands amplify cell penetration and nuclear targeting of anti-DNA antibodies via energy-independent mechanisms
- (2015) Markella Zannikou et al. IMMUNOLOGY
- Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus
- (2015) Juan P. Mackern-Oberti et al. IMMUNOLOGY
- Type I interferon and T helper 17 cells co-exist and co-regulate disease pathogenesis in lupus patients
- (2015) Partha S. Biswas et al. International Journal of Rheumatic Diseases
- Taming the TCR: Antigen-Specific Immunotherapeutic Agents for Autoimmune Diseases
- (2015) Evan L. Sauer et al. INTERNATIONAL REVIEWS OF IMMUNOLOGY
- Interferon-α induces altered transitional B cell signaling and function in Systemic Lupus Erythematosus
- (2015) Nan-Hua Chang et al. JOURNAL OF AUTOIMMUNITY
- Anti-dsDNA antibody induces soluble fibronectin secretion by proximal renal tubular epithelial cells and downstream increase of TGF-β1 and collagen synthesis
- (2015) Susan Yung et al. JOURNAL OF AUTOIMMUNITY
- TNF-related weak inducer of apoptosis (TWEAK) regulates junctional proteins in tubular epithelial cells via canonical NF-κB pathway and ERK activation
- (2015) Sergio Berzal et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Selective adsorption of antiphospholipid and anti-dsDNA autoantibodies on histidine based pseudobioaffinity adsorbent from sera of patients with systemic lupus erythematosus (SLE)
- (2015) Mcheik Zeinab et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- TWEAK/Fn14 Signaling Involvement in the Pathogenesis of Cutaneous Disease in the MRL/lpr Model of Spontaneous Lupus
- (2015) Jessica L. Doerner et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases
- (2015) April Barnado et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Anti-dsDNA antibodies induce inflammation via endoplasmic reticulum stress in human mesangial cells
- (2015) Hui Zhang et al. Journal of Translational Medicine
- Serum level of proximal renal tubular epithelial cell-binding immunoglobulin G in patients with lupus nephritis
- (2015) D Y H Yap et al. LUPUS
- Cell- and nuclear-penetrating anti-dsDNA autoantibodies have multiple arginines in CDR3 of VH and increase cellular level of pERK and Bcl-2 in mesangial cells
- (2015) Sae-Ran Im et al. MOLECULAR IMMUNOLOGY
- Unknown
- (2015) Ji Yang et al. MOLECULAR MEDICINE
- The anti-DNA antibody: origin and impact, dogmas and controversies
- (2015) Ole P. Rekvig Nature Reviews Rheumatology
- DNA-dependent targeting of cell nuclei by a lupus autoantibody
- (2015) Richard H. Weisbart et al. Scientific Reports
- DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia
- (2015) Evgeny A. Ermakov et al. Open Biology
- Neuroimmunology: An Expanding Frontier in Autoimmunity
- (2015) Romana Höftberger Frontiers in Immunology
- Mechanisms of Kidney Injury in Lupus Nephritis – the Role of Anti-dsDNA Antibodies
- (2015) Susan Yung et al. Frontiers in Immunology
- Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man
- (2015) Verena K. Raker et al. Frontiers in Immunology
- Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor
- (2015) Eric H. Chang et al. EBioMedicine
- Suppression of dsDNA-specific B lymphocytes reduces disease symptoms in SCID model of mouse lupus
- (2014) Vera Gesheva et al. AUTOIMMUNITY
- Systemic lupus erythematosus: Molecular cloning of fourteen recombinant DNase monoclonal kappa light chains with different catalytic properties
- (2014) Irina A. Kostrikina et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
- (2014) Qiming Liang et al. Cell Host & Microbe
- Anti-dsDNA antibodies as a classification criterion and a diagnostic marker for systemic lupus erythematosus: critical remarks
- (2014) O. P. Rekvig CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE
- (2014) Benjamin R. Umiker et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- SOCS signaling in autoimmune diseases: Molecular mechanisms and therapeutic implications
- (2014) Yan Liang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Antibodies specific for nucleic acids and applications in genomic detection and clinical diagnostics
- (2014) Zonglin Hu et al. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
- Novel approaches to the development of targeted therapeutic agents for systemic lupus erythematosus
- (2014) Zev Sthoeger et al. JOURNAL OF AUTOIMMUNITY
- Differential Contribution of Three Activating IgG Fc Receptors (Fc RI, Fc RIII, and Fc RIV) to IgG2a- and IgG2b-Induced Autoimmune Hemolytic Anemia in Mice
- (2014) L. Baudino et al. JOURNAL OF IMMUNOLOGY
- The Suppression of Murine Lupus by a Tolerogenic Peptide Involves Foxp3-Expressing CD8 Cells That Are Required for the Optimal Induction and Function of Foxp3-Expressing CD4 Cells
- (2014) A. Sharabi et al. JOURNAL OF IMMUNOLOGY
- Opposing Impact of B Cell-Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation
- (2014) S. W. Jackson et al. JOURNAL OF IMMUNOLOGY
- Deficiency of Fibroblast Growth Factor-Inducible 14 (Fn14) Preserves the Filtration Barrier and Ameliorates Lupus Nephritis
- (2014) Y. Xia et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Delivery of antibodies to the cytosol
- (2014) Andrea LJ Marschall et al. mAbs
- Autoreactive IgE Is Prevalent in Systemic Lupus Erythematosus and Is Associated with Increased Disease Activity and Nephritis
- (2014) Barbara Dema et al. PLoS One
- TGF- -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops
- (2014) J. Zhang et al. Science Signaling
- Immunoserological parameters in SLE: high-avidity anti-dsDNA detected by ELISA are the most closely associated with the disease activity
- (2013) Sladjana Andrejevic et al. CLINICAL RHEUMATOLOGY
- Nucleosomes contribute to increase mesangial cell chemokine expression during the development of lupus nephritis
- (2013) Premasany Kanapathippillai et al. CYTOKINE
- Significantly High Levels of Anti-dsDNA Immunoglobulin E in Sera and the Ability of dsDNA to Induce the Degranulation of Basophils from Chronic Urticaria Patients
- (2013) Yuko Hatada et al. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- Anti-DNA antibodies cross-react with C1q
- (2013) Giovanni Franchin et al. JOURNAL OF AUTOIMMUNITY
- Neuropsychiatric disease in murine lupus is dependent on the TWEAK/Fn14 pathway
- (2013) Jing Wen et al. JOURNAL OF AUTOIMMUNITY
- Blockade of Programmed Death-1 in Young (New Zealand Black x New Zealand White)F1 Mice Promotes the Suppressive Capacity of CD4+ Regulatory T Cells Protecting from Lupus-like Disease
- (2013) M. Wong et al. JOURNAL OF IMMUNOLOGY
- Molecular Basis of 9G4 B Cell Autoreactivity in Human Systemic Lupus Erythematosus
- (2013) C. Richardson et al. JOURNAL OF IMMUNOLOGY
- A surge in anti-dsDNA titer predicts a severe lupus flare within six months
- (2013) N Pan et al. LUPUS
- Dendritic and stromal cells from the spleen of lupic mice present phenotypic and functional abnormalities
- (2013) Maria Alejandra Gleisner et al. MOLECULAR IMMUNOLOGY
- The constant region affects antigen binding of antibodies to DNA by altering secondary structure
- (2013) Yumin Xia et al. MOLECULAR IMMUNOLOGY
- Anti-dsDNA Antibody Isotypes in Systemic Lupus Erythematosus: IgA in Addition to IgG Anti-dsDNA Help to Identify Glomerulonephritis and Active Disease
- (2013) Danilo Villalta et al. PLoS One
- Low diagnostic and predictive value of anti-dsDNA antibodies in unselected patients with recent onset of rheumatic symptoms: results from a long-term follow-up Scandinavian multicentre study
- (2013) M Compagno et al. SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
- The role of somatic hypermutation in the generation of pathogenic antibodies in SLE
- (2012) Kristin Schroeder et al. AUTOIMMUNITY
- The role of activation-induced deaminase in Lupus Nephritis
- (2012) Marilyn Diaz AUTOIMMUNITY
- IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice
- (2012) Neil S Greenspan et al. Biology Direct
- Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis
- (2012) Yumin Xia et al. CLINICAL IMMUNOLOGY
- IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE
- (2012) Caroline Grönwall et al. CLINICAL IMMUNOLOGY
- The antigen-binding fragment of anti-double-stranded DNA IgG enhances F-actin formation in mesangial cells by binding to alpha-actinin-4
- (2012) Xiaoyan Zou et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes
- (2012) Jill Henault et al. IMMUNITY
- The role of activation-induced deaminase in antibody diversification and genomic instability
- (2012) Jing H. Wang IMMUNOLOGIC RESEARCH
- TLR7 and TLR9 in SLE: when sensing self goes wrong
- (2012) T. Celhar et al. IMMUNOLOGIC RESEARCH
- Selective binding of anti-DNA antibodies to native dsDNA fragments of differing sequence
- (2012) Melissa B. Uccellini et al. IMMUNOLOGY LETTERS
- The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies
- (2012) Yumin Xia et al. JOURNAL OF AUTOIMMUNITY
- The Lupus-derived Anti-double-stranded DNA IgG Contributes to Myofibroblast-like Phenotype in Mesangial Cells
- (2012) Yi Zhang et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice
- (2012) Meera R. Krishnan et al. KIDNEY INTERNATIONAL
- Clinical significance of soluble-endoglin levels in systemic lupus erythematosus: possible association with anti-phospholipid syndrome
- (2012) IH Bassyouni et al. LUPUS
- Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis
- (2011) Chuancang Jiang et al. ARTHRITIS AND RHEUMATISM
- Nephritogenic antibodies bind in glomeruli through interaction with exposed chromatin fragments and not with renal cross-reactive antigens
- (2011) Janne Erikke Mjelle et al. AUTOIMMUNITY
- Anti-ribosomal P antibodies and lupus nephritis
- (2011) Shunsei Hirohata Clinical and Experimental Nephrology
- Tolerance induced by anti-DNA Ig peptide in (NZB×NZW)F1 lupus mice impinges on the resistance of effector T cells to suppression by regulatory T cells
- (2011) Yiyun Yu et al. CLINICAL IMMUNOLOGY
- Naturally occurring V region connected antibodies inhibit anti-dsDNA antibody reactivity with dsDNA
- (2011) Tatjana Srdic-Rajic et al. IMMUNOBIOLOGY
- Blockade of TLR9 signaling in B cells impaired anti-dsDNA antibody production in mice induced by activated syngenic lymphocyte-derived DNA immunization
- (2011) Min Chen et al. MOLECULAR IMMUNOLOGY
- Gene expression of TWEAK/Fn14 and IP-10/CXCR3 in glomerulus and tubulointerstitium of patients with lupus nephritis
- (2011) JIANXIN LU et al. NEPHROLOGY
- Antigen-specific immature dendritic cell vaccine ameliorates anti-dsDNA antibody-induced renal damage in a mouse model
- (2011) Y. Xia et al. RHEUMATOLOGY
- CD4+T-cell anergy induced by lin−CD117(c-kit)+stem cell-derived immature dendritic cells loaded with nuclear antigen derived fromTrypanosoma equiperdum
- (2010) Yumin Xia et al. AUTOIMMUNITY
- Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses
- (2010) Amit Golding et al. IMMUNOLOGY
- Moving towards a cure: blocking pathogenic antibodies in systemic lupus erythematosus
- (2010) B. Diamond et al. JOURNAL OF INTERNAL MEDICINE
- Anti-dsDNA Antibodies Bind to Mesangial Annexin II in Lupus Nephritis
- (2010) S. Yung et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Targeting Peptide Termini, a Novel Immunoaffinity Approach to Reduce Complexity in Mass Spectrometric Protein Identification
- (2010) Sibylle Hoeppe et al. MOLECULAR & CELLULAR PROTEOMICS
- Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations
- (2010) George K. Bertsias et al. Nature Reviews Rheumatology
- Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid
- (2009) Susan Yung et al. ARTHRITIS AND RHEUMATISM
- BioPlex™ 2200 multiplexed system: Simultaneous detection of anti-dsDNA and anti-chromatin antibodies in patients with systemic lupus erythematosus
- (2009) Nathalie Bardin et al. AUTOIMMUNITY
- B-cell activating factor (BAFF) plays a role in the mechanism of action of a tolerogenic peptide that ameliorates lupus
- (2009) Reshmi Parameswaran et al. CLINICAL IMMUNOLOGY
- TNF-like weak inducer of apoptosis (TWEAK) induces inflammatory and proliferative effects in human kidney cells
- (2009) Hua-Xin Gao et al. CYTOKINE
- Emerging roles of TLR7 and TLR9 in murine SLE
- (2009) Marie-Laure Santiago-Raber et al. JOURNAL OF AUTOIMMUNITY
- Treatment of lupus patients with a tolerogenic peptide, hCDR1 (Edratide): Immunomodulation of gene expression
- (2009) Zev M. Sthoeger et al. JOURNAL OF AUTOIMMUNITY
- Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice
- (2009) Marie-Laure Santiago-Raber et al. JOURNAL OF AUTOIMMUNITY
- PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
- (2009) Loise M. Francisco et al. JOURNAL OF EXPERIMENTAL MEDICINE
- A Possible Link between Infection with Burkholderia Bacteria and Systemic Lupus Erythematosus Based on Epitope Mimicry
- (2008) Wei Zhang et al. Clinical & Developmental Immunology
- Arginines in the CDR of anti-dsDNA autoantibodies facilitate cell internalizationviaelectrostatic interactions
- (2008) Ying-Chyi Song et al. EUROPEAN JOURNAL OF IMMUNOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation