The role of activation-induced deaminase in antibody diversification and genomic instability

Cutting Edge: A cis-Acting DNA Element Targets AID-Mediated Sequence Diversification to the Chicken Ig Light Chain Gene Locus

(2014) N. Kothapalli et al.   JOURNAL OF IMMUNOLOGY

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)

(2012) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

(2011) Uttiya Basu et al.   CELL

Targeting of AID-mediated sequence diversification to immunoglobulin genes

(2011) Naga Rama Kothapalli et al.   CURRENT OPINION IN IMMUNOLOGY

AID and partners: for better and (not) for worse

(2011) Sébastien Storck et al.   CURRENT OPINION IN IMMUNOLOGY

The relationship between hypothesis and experiment in unveiling the mechanisms of antibody gene diversification

(2011) Karuna Ganesh et al.   FASEB JOURNAL

Human Mre11/Human Rad50/Nbs1 and DNA Ligase IIIα/XRCC1 Protein Complexes Act Together in an Alternative Nonhomologous End Joining Pathway

(2011) Julie Della-Maria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination

(2011) Beena Patricia Jeevan-Raj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining inIghgenes

(2011) Huseyin Saribasak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activation-Induced Cytidine Deaminase Induces Reproducible DNA Breaks at Many Non-Ig Loci in Activated B Cells

(2011) Ori Staszewski et al.   MOLECULAR CELL

Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination

(2011) L. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of Immunoglobulin V-Region Diversification Regulated by Transcription and RNA Metabolism in Antigen-Driven B Cells

(2011) N. Sakaguchi et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Complex regulation and function of activation-induced cytidine deaminase

(2011) Janet Stavnezer   TRENDS IN IMMUNOLOGY

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Activation-Induced Cytidine Deaminase Accelerates Clonal Evolution in BCR-ABL1-Driven B-Cell Lineage Acute Lymphoblastic Leukemia

(2010) T. A. Gruber et al.   CANCER RESEARCH

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

Controlling somatic hypermutation in immunoglobulin variable and switch regions

(2010) Robert W. Maul et al.   IMMUNOLOGIC RESEARCH

GANP-mediated Recruitment of Activation-induced Cytidine Deaminase to Cell Nuclei and to Immunoglobulin Variable Region DNA

(2010) Kazuhiko Maeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

(2010) Cristian Boboila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Attracting AID to targets of somatic hypermutation

(2010) Atsushi Tanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA

(2010) Urszula Nowak et al.   NATURE IMMUNOLOGY

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

(2010) Arito Yamane et al.   NATURE IMMUNOLOGY

14-3-3 adaptor proteins recruit AID to 5′-AGCT-3′–rich switch regions for class switch recombination

(2010) Zhenming Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

(2010) C. Boboila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination

(2010) A. Stanlie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination

(2010) J. A. Daniel et al.   SCIENCE

The B Cell Mutator AID Promotes B Lymphoid Blast Crisis and Drug Resistance in Chronic Myeloid Leukemia

(2009) Lars Klemm et al.   CANCER CELL

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

(2009) Chunru Lin et al.   CELL

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

(2009) Z. Sabouri et al.   INTERNATIONAL IMMUNOLOGY

Immunoglobulin switch μ sequence causes RNA polymerase II accumulation and reduces dA hypermutation

(2009) Deepa Rajagopal et al.   JOURNAL OF EXPERIMENTAL MEDICINE

S region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombination

(2009) Lili Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Class Switch Recombination Efficiency and Junction Microhomology Patterns in Msh2-, Mlh1-, and Exo1-Deficient Mice Depend on the Presence of   Switch Region Tandem Repeats

(2009) J. Eccleston et al.   JOURNAL OF IMMUNOLOGY

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

(2009) Davide F. Robbiani et al.   MOLECULAR CELL

Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates

(2009) Ludovic Deriano et al.   MOLECULAR CELL

Mechanisms promoting translocations in editing and switching peripheral B cells

(2009) Jing H. Wang et al.   NATURE

A coming-of-age story: activation-induced cytidine deaminase turns 10

(2009) Rebecca K Delker et al.   NATURE IMMUNOLOGY

Mre11: roles in DNA repair beyond homologous recombination

(2009) Shan Zha et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Multiple functions of MRN in end-joining pathways during isotype class switching

(2009) Maria Dinkelmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of mammalian Mre11 in classical and alternative nonhomologous end joining

(2009) Anyong Xie et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

(2009) Hwei-Ling Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Balancing AID and DNA repair during somatic hypermutation

(2009) Man Liu et al.   TRENDS IN IMMUNOLOGY

A cis-Acting Diversification Activator Both Necessary and Sufficient for AID-Mediated Hypermutation

(2009) Artem Blagodatski et al.   PLoS Genetics

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

The discovery and application of gene fusions in prostate cancer

(2008) David S. Morris et al.   BJU INTERNATIONAL

Molecular biology of bcr-abl1-positive chronic myeloid leukemia

(2008) A. Quintas-Cardama et al.   BLOOD

Non-solid oncogenes in solid tumors:EML4-ALKfusion genes in lung cancer

(2008) Hiroyuki Mano   CANCER SCIENCE

AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations

(2008) Davide F. Robbiani et al.   CELL

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

(2008) Jing H. Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE

The roles of APE1, APE2, DNA polymerase   and mismatch repair in creating S region DNA breaks during antibody class switch

(2008) C. E Schrader et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS