SOCS signaling in autoimmune diseases: Molecular mechanisms and therapeutic implications

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Angela Lee et al.   ARTHRITIS AND RHEUMATISM

Suppression of cytokine signaling: The SOCS perspective

(2013) Edmond M. Linossi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses

(2013) Stefania Madonna et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and functionin vitroandin vivo

(2013) Christina E. Arnold et al.   IMMUNOLOGY

miR-150 Promotes Renal Fibrosis in Lupus Nephritis by Downregulating SOCS1

(2013) H. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

(2013) Xuexian O Yang et al.   NATURE IMMUNOLOGY

Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

(2012) B. T. van den Brand et al.   ARTHRITIS AND RHEUMATISM

The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter

(2012) Takayuki Satoh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

JAK's SOCS: A Mechanism of Inhibition

(2012) Akihiko Yoshimura et al.   IMMUNITY

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

Constitutive Phosphorylation of Interferon Receptor A-Associated Signaling Proteins in Systemic Lupus Erythematosus

(2012) Gabriela Ramírez-Vélez et al.   PLoS One

Dysregulation of Suppressor of Cytokine Signaling 3 in Keratinocytes Causes Skin Inflammation Mediated by Interleukin-20 Receptor-Related Cytokines

(2012) Ayako Uto-Konomi et al.   PLoS One

Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis

(2012) S Madonna et al.   Cell Death & Disease

A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis

(2011) S. Veenbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

(2011) Reiko Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of SOCS1-/- Lethal Autoinflammatory Disease Correlated to Enhanced Peripheral Foxp3+ Regulatory T Cell Homeostasis

(2011) E. L. Collins et al.   JOURNAL OF IMMUNOLOGY

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

(2011) Zhi-Ping Feng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance

(2011) Takatoshi Chinen et al.   Nature Communications

The IFN- -Dependent Suppressor of Cytokine Signaling 1 Promoter Activity Is Positively Regulated by IFN Regulatory Factor-1 and Sp1 but Repressed by Growth Factor Independence-1b and Kruppel-Like Factor-4, and It Is Dysregulated in Psoriatic Keratinocytes

(2010) S. Madonna et al.   JOURNAL OF IMMUNOLOGY

Deficient SOCS3 and SHP-1 Expression in Psoriatic T Cells

(2010) Karsten W. Eriksen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Suppressor of cytokine signaling 1 gene expression and polymorphisms in systemic lupus erythematosus

(2010) HC Chan et al.   LUPUS

Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice

(2010) S. Wang et al.   LUPUS

Identification of a Common Lupus Disease-Associated microRNA Expression Pattern in Three Different Murine Models of Lupus

(2010) Rujuan Dai et al.   PLoS One

Suppressor of cytokine signaling-1 inhibits caspase activation and protects from cytokine-induced beta cell death

(2009) Irina I. Zaitseva et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

(2009) Li-Fan Lu et al.   IMMUNITY

SOCS3 in T and NKT Cells Negatively Regulates Cytokine Production and Ameliorates ConA-Induced Hepatitis

(2009) M. Nakaya et al.   JOURNAL OF IMMUNOLOGY

Stage Dependent Aberrant Regulation of Cytokine-STAT Signaling in Murine Systemic Lupus Erythematosus

(2009) Matthew B. Hale et al.   PLoS One

Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling

(2009) P. Pflegerl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function

(2009) Douglas C. Palmer et al.   TRENDS IN IMMUNOLOGY

The analysis of CIS, SOCS1, SOSC2 and SOCS3 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients

(2008) Jeng-Ting Tsao et al.   CLINICAL AND EXPERIMENTAL MEDICINE

The many faces of the SOCS box

(2008) Julie Piessevaux et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Suppressor of cytokine signalling-3 expression inhibits cytokine-mediated destruction of primary mouse and rat pancreatic islets and delays allograft rejection

(2008) S. G. Rønn et al.   DIABETOLOGIA