Taming the TCR: Antigen-Specific Immunotherapeutic Agents for Autoimmune Diseases

Loss of IFN-  Enables the Expansion of Autoreactive CD4+ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen

(2014) J. J. Sabatino et al.   JOURNAL OF IMMUNOLOGY

MHC Class II Derived Recombinant T Cell Receptor Ligands Protect DBA/1LacJ Mice from Collagen-Induced Arthritis

(2014) J. Huan et al.   JOURNAL OF IMMUNOLOGY

Correlation of Blood T Cell and Antibody Reactivity to Myelin Proteins with HLA Type and Lesion Localization in Multiple Sclerosis

(2014) Judith M. Greer et al.   JOURNAL OF IMMUNOLOGY

MHC Variant Peptide-Mediated Anergy of Encephalitogenic T Cells Requires SHP-1

(2014) H. A. Wasserman et al.   JOURNAL OF IMMUNOLOGY

Route of Uptake of Palmitoylated Encephalitogenic Peptides of Myelin Proteolipid Protein by Antigen-Presenting Cells: Importance of the Type of Bond between Lipid Chain and Peptide and Relevance to Autoimmunity

(2014) N. A. Pfender et al.   JOURNAL OF IMMUNOLOGY

HLA Class II Molecules Influence Susceptibility versus Protection in Inflammatory Diseases by Determining the Cytokine Profile

(2013) A. K. Mangalam et al.   JOURNAL OF IMMUNOLOGY

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction

(2012) Marie-Christophe Boissier et al.   JOURNAL OF AUTOIMMUNITY

A novel regulatory pathway for autoimmune disease: Binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

(2012) Arthur A. Vandenbark et al.   JOURNAL OF AUTOIMMUNITY

Self-reactive human CD4 T cell clones form unusual immunological synapses

(2012) David A. Schubert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GAD65 Antigen Therapy in Recently Diagnosed Type 1 Diabetes Mellitus

(2012) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Soluble MOG35-55/I-Ab Dimers Ameliorate Experimental Autoimmune Encephalomyelitis by Reducing Encephalitogenic T Cells

(2012) Yeli Gong et al.   PLoS One

HLA and Celiac Disease Susceptibility: New Genetic Factors Bring Open Questions about the HLA Influence and Gene-Dosage Effects

(2012) Luz María Medrano et al.   PLoS One

Acetylcholine Receptor-Induced Experimental Myasthenia Gravis: What Have We Learned from Animal Models After Three Decades?

(2011) Fulvio Baggi et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway

(2011) Monika-Sarah ED Schulze et al.   CURRENT OPINION IN IMMUNOLOGY

Experimental models of multiple sclerosis

(2011) Andrew R Pachner   CURRENT OPINION IN NEUROLOGY

Effector T cells in rheumatoid arthritis: Lessons from animal models

(2011) Saba Alzabin et al.   FEBS LETTERS

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

RTL551 Treatment of EAE Reduces CD226 and T-bet+ CD4 T Cells in Periphery and Prevents Infiltration of T-bet+ IL-17, IFN-γ Producing T Cells into CNS

(2011) Sushmita Sinha et al.   PLoS One

Routes to manipulate MHC class II antigen presentation

(2010) Tineke van den Hoorn et al.   CURRENT OPINION IN IMMUNOLOGY

Reversal of type 1 diabetes by a new MHC II-peptide chimera: “Single-epitope-mediated suppression” to stabilize a polyclonal autoimmune T-cell process

(2010) Marvin Lin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

A proinsulin74-90 -derived protease-resistant, altered peptide ligand increases TGF-β1 secretion in PBMC from patients with type 1 diabetes mellitus

(2010) Denise van Aalst et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis

(2010) Sushmita Sinha et al.   JOURNAL OF NEUROIMMUNOLOGY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Strategies and Limitations in Dendrimeric Immunogen Synthesis. The Influenza Virus M2e Epitope as a Case Study

(2009) Wioleta Kowalczyk et al.   BIOCONJUGATE CHEMISTRY

No Effect of the Altered Peptide Ligand NBI-6024 on  -Cell Residual Function and Insulin Needs in New-Onset Type 1 Diabetes

(2009) M. Walter et al.   DIABETES CARE

Organization of proximal signal initiation at the TCR:CD3 complex

(2009) Clifford S. Guy et al.   IMMUNOLOGICAL REVIEWS

Suppression of Ongoing T Cell-Mediated Autoimmunity by Peptide-MHC Class II Dimer Vaccination

(2009) L. Li et al.   JOURNAL OF IMMUNOLOGY

Peptide-MHC Class II Complex Stability Governs CD4 T Cell Clonal Selection

(2009) C. K. Baumgartner et al.   JOURNAL OF IMMUNOLOGY

Protease-resistant human GAD-derived altered peptide ligands decrease TNF-α and IL-17 production in peripheral blood cells from patients with type 1 diabetes mellitus

(2009) Bernhard O. Boehm et al.   MOLECULAR IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Abortive activation of CD4 T cell responses during competitive priming in vivo

(2009) J. M. Weaver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosally induced Immunological Tolerance, Regulatory T Cells and the Adjuvant Effect by Cholera Toxin B Subunit

(2009) J.-B. Sun et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response

(2009) R. Li et al.   TISSUE ANTIGENS

The HLA gene complex in thyroid autoimmunity: From epidemiology to etiology

(2008) Eric M. Jacobson et al.   JOURNAL OF AUTOIMMUNITY

Mucosal administration of an altered CII263-272 peptide inhibits collagen-induced arthritis by suppression of Th1/Th17 cells and expansion of regulatory T cells

(2008) Jinxia Zhao et al.   RHEUMATOLOGY INTERNATIONAL