The role of somatic hypermutation in the generation of pathogenic antibodies in SLE

Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface

(2012) Giovanni Di Zenzo et al.   JOURNAL OF CLINICAL INVESTIGATION

B Cell Tolerance and Positive Selection in Lupus

(2012) D. Eilat et al.   JOURNAL OF IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Selective Utilization of Toll-like Receptor and MyD88 Signaling in B Cells for Enhancement of the Antiviral Germinal Center Response

(2011) Baidong Hou et al.   IMMUNITY

Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus

(2011) Sulaiman M Al-Mayouf et al.   NATURE GENETICS

IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE

(2010) Luis E. Munoz et al.   AUTOIMMUNITY

Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity

(2010) Wenzhong Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of self-reactive germinal center B cells and plasma cells in autoimmune FcγRIIB-deficient mice

(2010) Thomas Tiller et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus

(2009) Luis E. Muñoz et al.   ARTHRITIS AND RHEUMATISM

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus

(2009) Nicholas Simpson et al.   ARTHRITIS AND RHEUMATISM

Lupus-prone MRL/faslpr/lprmice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: Concurrent upregulation of somatic hypermutation and class switch DNA recombination

(2009) Hong Zan et al.   AUTOIMMUNITY

Lupus Nephritis

(2008) Elin S. Mortensen et al.   AMERICAN JOURNAL OF PATHOLOGY

Clearance deficiency—A potential link between infections and autoimmunity

(2008) C. Schulze et al.   AUTOIMMUNITY REVIEWS

Activation-induced deaminase heterozygous MRL/lpr mice are delayed in the production of high-affinity pathogenic antibodies and in the development of lupus nephritis

(2008) Chuancang Jiang et al.   IMMUNOLOGY

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

(2008) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

(2008) B. Mietzner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA