Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)

Dietary Carotenoids and Non-Alcoholic Fatty Liver Disease among US Adults, NHANES 2003–2014

(2019) Krista Christensen et al.   Nutrients

Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor

(2018) Erica E. Alexeev et al.   AMERICAN JOURNAL OF PATHOLOGY

Nonalcoholic Fatty Liver Disease and Metabolic Syndrome

(2018) Donghee Kim et al.   Clinics in Liver Disease

The gut microbiota metabolite indole alleviates liver inflammation in mice

(2018) Martin Beaumont et al.   FASEB JOURNAL

Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1–IKKϵ–IRF3 axis activation

(2018) Hiroki Tsukamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide from Bacterial Outer Membrane Vesicles

(2018) Lan Gu et al.   SHOCK

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

(−)-Epigallocatechin-3-gallate (EGCG) inhibits starch digestion and improves glucose homeostasis through direct or indirect activation of PXR/CAR-mediated phase II metabolism in diabetic mice

(2018) Xiaopeng Li et al.   Food & Function

Butyrate Protects Mice Against Methionine–Choline-Deficient Diet-Induced Non-alcoholic Steatohepatitis by Improving Gut Barrier Function, Attenuating Inflammation and Reducing Endotoxin Levels

(2018) Jianzhong Ye et al.   Frontiers in Microbiology

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

(2018) Joeri Tulkens et al.   GUT

Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome

(2018) Luigi Barrea et al.   Nutrients

Loss of lipopolysaccharide-binding protein attenuates the development of diet-induced non-alcoholic fatty liver disease in mice

(2017) Cheng Jun Jin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+Thymocyte Selection

(2017) Marianne M. Martinic et al.   JOURNAL OF IMMUNOLOGY

The role of bile acids in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2017) Monica D. Chow et al.   MOLECULAR ASPECTS OF MEDICINE

Sodium butyrate attenuates high-fat diet-induced steatohepatitis in mice by improving gut microbiota and gastrointestinal barrier

(2017) Da Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour

(2017) Anders Abildgaard et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss

(2017) Fernando F. Anhê et al.   Molecular Metabolism

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota

(2016) A. Sloan Devlin et al.   Cell Host & Microbe

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Bile Acids and the Potential Role in Primary Biliary Cirrhosis

(2016) Hang Yang et al.   DIGESTION

Effects of bile acids on neurological function and disease

(2016) Matthew McMillin et al.   FASEB JOURNAL

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Hepatocyte mitochondrial DNA drives nonalcoholic steatohepatitis by activation of TLR9

(2016) Irma Garcia-Martinez et al.   JOURNAL OF CLINICAL INVESTIGATION

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Bacterial outer membrane vesicles: New insights and applications

(2016) Deepak Anand et al.   MOLECULAR MEMBRANE BIOLOGY

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

(2016) Katja Koeppen et al.   PLoS Pathogens

Carotenoids Functionality, Sources, and Processing by Supercritical Technology: A Review

(2016) Natália Mezzomo et al.   Journal of Chemistry

Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH

(2016) Xingyong Wan et al.   Canadian Journal of Gastroenterology and Hepatology

GPR41 and GPR43 in Obesity and Inflammation – Protective or Causative?

(2016) Zhiwei Ang et al.   Frontiers in Immunology

Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism

(2016) Limin Zhang et al.   mSystems

Bacterial endotoxin and non-alcoholic fatty liver disease in the general population: a prospective cohort study

(2015) V. W.-S. Wong et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Hepatic TLR4 signaling in obese NAFLD

(2015) Torfay Sharifnia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Supplementation of sodium butyrate protects mice from the development of non-alcoholic steatohepatitis (NASH)

(2015) Cheng Jun Jin et al.   BRITISH JOURNAL OF NUTRITION

Expression of odorant receptor Olfr78 in enteroendocrine cells of the colon

(2015) Joerg Fleischer et al.   CELL AND TISSUE RESEARCH

Presepsin (sCD14-ST), an innate immune response marker in sepsis

(2015) Camille Chenevier-Gobeaux et al.   CLINICA CHIMICA ACTA

Olfaction in the kidney: ‘smelling’ gut microbial metabolites

(2015) Niranjana Natarajan et al.   EXPERIMENTAL PHYSIOLOGY

Role of serum toll-like receptors 2 and 4 in non-alcoholic steatohepatitis and liver fibrosis

(2015) Mustafa Cengiz et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88

(2015) Shuhong Guo et al.   JOURNAL OF IMMUNOLOGY

TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus

(2015) Marco Túlio Gomes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interactions between the intestinal microbiota and bile acids in gallstones patients

(2015) Nirit Keren et al.   Environmental Microbiology Reports

LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease

(2015) Sara Ceccarelli et al.   Oncotarget

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E

(2015) Yinhua Ni et al.   Scientific Reports

The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance

(2015) Manya Warrier et al.   Cell Reports

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Identification and Characterization of Outer Membrane Vesicle-Associated Proteins in Salmonella enterica Serovar Typhimurium

(2014) Jaewoo Bai et al.   INFECTION AND IMMUNITY

Brown Alga Ecklonia cava Polyphenol Extract Ameliorates Hepatic Lipogenesis, Oxidative Stress, and Inflammation by Activation of AMPK and SIRT1 in High-Fat Diet-Induced Obese Mice

(2014) Hyeyoon Eo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

(2014) Diana M. Shih et al.   JOURNAL OF LIPID RESEARCH

One-week high-fat diet leads to reduced toll-like receptor 2 expression and function in young healthy men

(2014) Zhongxiao Wan et al.   NUTRITION RESEARCH

Gut microbiome and nonalcoholic fatty liver diseases

(2014) Lixin Zhu et al.   PEDIATRIC RESEARCH

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

(2014) Guiyu Lou et al.   PLoS One

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease

(2014) Kouichi Miura   WORLD JOURNAL OF GASTROENTEROLOGY

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

(2014) Catalin Chimerel et al.   Cell Reports

Role of Innate Immune Response in Non-Alcoholic Fatty Liver Disease: Metabolic Complications and Therapeutic Tools

(2014) Rosaria Meli et al.   Frontiers in Immunology

Regulation of Energy Homeostasis by GPR41

(2014) Daisuke Inoue et al.   Frontiers in Endocrinology

The SCFA Receptor GPR43 and Energy Metabolism

(2014) Ikuo Kimura et al.   Frontiers in Endocrinology

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Lipopolysaccharides accelerate hepatic steatosis in the development of nonalcoholic fatty liver disease in Zucker rats

(2013) Shinya Fukunishi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders

(2013) Philip B Busbee et al.   NUTRITION REVIEWS

Soluble CD14 Levels Reflect Liver Inflammation in Patients with Nonalcoholic Steatohepatitis

(2013) Yuji Ogawa et al.   PLoS One

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

(2012) Shuhong Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content

(2012) Mohamed Bellahcene et al.   BRITISH JOURNAL OF NUTRITION

Formation of Phenolic Microbial Metabolites and Short-Chain Fatty Acids from Rye, Wheat, and Oat Bran and Their Fractions in the Metabolical in Vitro Colon Model

(2012) Emilia Nordlund et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bile Acids Induce Pancreatic Acinar Cell Injury and Pancreatitis by Activating Calcineurin

(2012) Kamaldeen A. Muili et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway

(2012) Kyung-Ah Kim et al.   PLoS One

Indole Production Promotes Escherichia coli Mixed-Culture Growth with Pseudomonas aeruginosa by Inhibiting Quorum Signaling

(2011) Weihua Chu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Diet-induced Obesity Up-regulates the Abundance of GPR43 and GPR120 in a Tissue Specific Manner

(2011) Lauren M. Cornall et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

NOD1 Activators Link Innate Immunity to Insulin Resistance

(2011) J. D. Schertzer et al.   DIABETES

Molecular basis of indole production catalyzed by tryptophanase in the genus Prevotella

(2011) Takako Sasaki-Imamura et al.   FEMS MICROBIOLOGY LETTERS

NOD-Like Receptor Activation by Outer Membrane Vesicles fromVibrio choleraeNon-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR

(2011) H. Bielig et al.   INFECTION AND IMMUNITY

Mycobacteria release active membrane vesicles that modulate immune responses in a TLR2-dependent manner in mice

(2011) Rafael Prados-Rosales et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Dietary Fiber in the Bioaccessibility and Bioavailability of Fruit and Vegetable Antioxidants

(2011) Hugo Palafox-Carlos et al.   JOURNAL OF FOOD SCIENCE

Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa

(2011) Dong-Sic Choi et al.   PROTEOMICS

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

(2010) Mikael Bjursell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Production of Indole from L-Tryptophan and Effects of These Compounds on Biofilm Formation by Fusobacterium nucleatum ATCC 25586

(2010) T. Sasaki-Imamura et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease

(2010) Zhao-Xia Yang et al.   Hepatology International

Elevated endotoxin levels in non-alcoholic fatty liver disease

(2010) Alison L Harte et al.   Journal of Inflammation-London

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Phylogenetic and Evolutionary Patterns in Microbial Carotenoid Biosynthesis Are Revealed by Comparative Genomics

(2010) Jonathan L. Klassen   PLoS One

Contribution of Gut Bacteria to Liver Pathobiology

(2010) Gakuhei Son et al.   Gastroenterology Research and Practice

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus

(2009) In Koo Hwang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of Diaminopimelic Acid Containing Peptidoglycan Fragments and Tracheal Cytotoxin (TCT) and Investigation of Their Biological Functions

(2008) Akiko Kawasaki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bacterial Peptidoglycan-Degrading Enzymes and Their Impact on Host Muropeptide Detection

(2008) Jessica Humann et al.   Journal of Innate Immunity

Attenuation of the cardiovascular and metabolic complications of obesity in CD14 knockout mice

(2008) Roberto Roncon-Albuquerque et al.   LIFE SCIENCES

Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay

(2007) Yoshiaki Amakura et al.   PHYTOCHEMISTRY