Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1–IKKϵ–IRF3 axis activation

An inhibitory epitope of human Toll-like receptor 4 resides on leucine-rich repeat 13 and is recognized by a monoclonal antibody

(2017) Hiroki Tsukamoto et al.   FEBS LETTERS

Reconstruction of LPS Transfer Cascade Reveals Structural Determinants within LBP, CD14, and TLR4-MD2 for Efficient LPS Recognition and Transfer

(2017) Je-Kyung Ryu et al.   IMMUNITY

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Mechanisms of Toll-like Receptor 4 Endocytosis Reveal a Common Immune-Evasion Strategy Used by Pathogenic and Commensal Bacteria

(2015) Yunhao Tan et al.   IMMUNITY

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance

(2015) Rajesh Rajaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

(2014) Kevin S. Bonham et al.   CELL

TRAM Is Required for TLR2 Endosomal Signaling to Type I IFN Induction

(2014) Julianne Stack et al.   JOURNAL OF IMMUNOLOGY

MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface

(2013) Hiroki Tsukamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs

(2012) H. Tsukamoto et al.   INTERNATIONAL IMMUNOLOGY

Reduced Surface Expression of TLR4 by a V254I Point Mutation Accounts for the Low Lipopolysaccharide Responder Phenotype of BALB/c B Cells

(2012) H. Tsukamoto et al.   JOURNAL OF IMMUNOLOGY

Defining the subcellular sites of innate immune signal transduction

(2012) Jonathan C. Kagan   TRENDS IN IMMUNOLOGY

Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule

(2011) Ralf R. Schumann   BIOCHEMICAL SOCIETY TRANSACTIONS

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

(2011) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells

(2010) H. Tsukamoto et al.   INTERNATIONAL IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY