Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule

Cellular response to small molecules that selectively stall protein synthesis by the ribosome

(2019) Nadège Liaud et al.   PLoS Genetics

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

(2018) Jinzhong Lin et al.   Annual Review of Biochemistry

Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

(2018) Allyn T. Londregan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ribosome Display: A Potent Display Technology used for Selecting and Evolving Specific Binders with Desired Properties

(2018) Ruowei Li et al.   MOLECULAR BIOTECHNOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

UMI-tools: modeling sequencing errors in Unique Molecular Identifiers to improve quantification accuracy

(2017) Tom Smith et al.   GENOME RESEARCH

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P

(2017) Paul Huter et al.   MOLECULAR CELL

Visualization of chemical modifications in the human 80S ribosome structure

(2017) S. Kundhavai Natchiar et al.   NATURE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

(2017) Mashal M. Almutairi et al.   NUCLEIC ACIDS RESEARCH

Ribosome structural dynamics in translocation: yet another functional role for ribosomal RNA

(2017) Harry F. Noller et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

(2017) Nathanael G. Lintner et al.   PLOS BIOLOGY

The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling

(2017) Ting Su et al.   eLife

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Choreography of molecular movements during ribosome progression along mRNA

(2016) Riccardo Belardinelli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center

(2016) James Marks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–function insights reveal the human ribosome as a cancer target for antibiotics

(2016) Alexander G. Myasnikov et al.   Nature Communications

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

(2016) Michael R Wasserman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Choreography of molecular movements during ribosome progression along mRNA

(2016) Riccardo Belardinelli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SeqKit: A Cross-Platform and Ultrafast Toolkit for FASTA/Q File Manipulation

(2016) Wei Shen et al.   PLoS One

Structural Snapshots of Actively Translating Human Ribosomes

(2015) Elmar Behrmann et al.   CELL

Structural basis for stop codon recognition in eukaryotes

(2015) Alan Brown et al.   NATURE

High-resolution structure of the Escherichia coli ribosome

(2015) Jonas Noeske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of a human translation termination complex

(2015) Sarah Matheisl et al.   NUCLEIC ACIDS RESEARCH

High-resolution structure of the Escherichia coli ribosome

(2015) Jonas Noeske et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of ribosome stalling by SecM at multiple elongation steps

(2015) Jun Zhang et al.   eLife

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution

(2014) Rebecca M. Voorhees et al.   CELL

Structural basis for the inhibition of the eukaryotic ribosome

(2014) Nicolas Garreau de Loubresse et al.   NATURE

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome

(2014) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The general mode of translation inhibition by macrolide antibiotics

(2014) Krishna Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrolide antibiotics allosterically predispose the ribosome for translation arrest

(2014) Shanmugapriya Sothiselvam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Dynamics of SecM-Induced Translational Stalling

(2014) Albert Tsai et al.   Cell Reports

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Generating Efficient Quantum Chemistry Codes for Novel Architectures

(2012) Alexey V. Titov et al.   Journal of Chemical Theory and Computation

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

The Arginine Attenuator Peptide Interferes with the Ribosome Peptidyl Transferase Center

(2012) J. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The Elongation, Termination, and Recycling Phases of Translation in Eukaryotes

(2012) T. E. Dever et al.   Cold Spring Harbor Perspectives in Biology

Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action

(2011) Krishna Kannan et al.   Annals of the New York Academy of Sciences

The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling

(2011) Daniel N Wilson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Insights into the molecular determinants of EF-G catalyzed translocation

(2011) L. Wang et al.   RNA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Probing Translation with Small-Molecule Inhibitors

(2010) Scott C. Blanchard et al.   CHEMISTRY & BIOLOGY

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel

(2010) Shashi Bhushan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Quantum Chemistry on Graphical Processing Units. 3. Analytical Energy Gradients, Geometry Optimization, and First Principles Molecular Dynamics

(2009) Ivan S. Ufimtsev et al.   Journal of Chemical Theory and Computation