Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides

(2015) Mashal M. Almutairi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly

(2015) Yury S Polikanov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Markerless Escherichia coli rrn Deletion Strains for Genetic Determination of Ribosomal Binding Sites

(2015) Selwyn Quan et al.   G3-Genes Genomes Genetics

The general mode of translation inhibition by macrolide antibiotics

(2014) Krishna Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence selectivity of macrolide-induced translational attenuation

(2014) A. R. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tools for Characterizing Bacterial Protein Synthesis Inhibitors

(2013) Cédric Orelle et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin

(2013) Douglas A. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identifying the targets of aminoacyl-tRNA synthetase inhibitors by primer extension inhibition

(2013) Cédric Orelle et al.   NUCLEIC ACIDS RESEARCH

Selective Protein Synthesis by Ribosomes with a Drug-Obstructed Exit Tunnel

(2012) Krishna Kannan et al.   CELL

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis of Pikromycin

(2011) Hong-Se Oh et al.   JOURNAL OF ORGANIC CHEMISTRY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Revisiting the structures of several antibiotics bound to the bacterial ribosome

(2010) D. Bulkley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Total synthesis of methymycin

(2009) Hong-Se Oh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The methymycin/pikromycin pathway: A model for metabolic diversity in natural product biosynthesis

(2008) Jeffrey D. Kittendorf et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Genome Sequence of a Nephritogenic and Highly Transformable M49 Strain of Streptococcus pyogenes

(2008) W. M. McShan et al.   JOURNAL OF BACTERIOLOGY

Molecular Mechanism of Drug-Dependent Ribosome Stalling

(2008) Nora Vazquez-Laslop et al.   MOLECULAR CELL