Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation

Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation

(2015) Jinzhong Lin et al.   CELL

Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis

(2015) Angelica Ferguson et al.   MOLECULAR CELL

Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions

(2015) Michael R. Wasserman et al.   Nature Communications

Fluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome

(2015) Sarah Adio et al.   Nature Communications

Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis

(2014) Wolf Holtkamp et al.   BIOESSAYS

Programmed –1 Frameshifting by Kinetic Partitioning during Impeded Translocation

(2014) Neva Caliskan et al.   CELL

Fusidic Acid Targets Elongation Factor G in Several Stages of Translocation on the Bacterial Ribosome

(2014) Anneli Borg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocation

(2014) J. Zhou et al.   SCIENCE

Structural Basis of the Translational Elongation Cycle

(2013) Rebecca M. Voorhees et al.   Annual Review of Biochemistry

Coordinated conformational and compositional dynamics drive ribosome translocation

(2013) Jin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Visualization of two transfer RNAs trapped in transit during elongation factor G-mediated translocation

(2013) D. J. F. Ramrath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the ribosome with elongation factor G trapped in the pretranslocation state

(2013) A. F. Brilot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structures of EF-G-Ribosome Complexes Trapped in Intermediate States of Translocation

(2013) J. Zhou et al.   SCIENCE

How Should We Think About the Ribosome?

(2012) Peter B. Moore   Annual Review of Biophysics

Unraveling the dynamics of ribosome translocation

(2012) Jin Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Enhanced photostability of cyanine fluorophores across the visible spectrum

(2012) Roger B Altman et al.   NATURE METHODS

Allosteric control of the ribosome by small-molecule antibiotics

(2012) Leyi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural characterization of mRNA-tRNA translocation intermediates

(2012) X. Agirrezabala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rotation of the head of the 30S ribosomal subunit during mRNA translocation

(2012) Z. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms and implications of programmed translational frameshifting

(2012) Jonathan D. Dinman   Wiley Interdisciplinary Reviews-RNA

Single-Molecule Fluorescence Measurements of Ribosomal Translocation Dynamics

(2011) Chunlai Chen et al.   MOLECULAR CELL

Messenger RNA interactions in the decoding center control the rate of translocation

(2011) Prashant K Khade et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

mRNA translocation occurs during the second step of ribosomal intersubunit rotation

(2011) Dmitri N Ermolenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis

(2011) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the molecular determinants of EF-G catalyzed translocation

(2011) L. Wang et al.   RNA

Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding

(2011) J. A. Dunkle et al.   SCIENCE

Conformational Sampling of Aminoacyl-tRNA during Selection on the Bacterial Ribosome

(2010) Peter Geggier et al.   JOURNAL OF MOLECULAR BIOLOGY

Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy

(2010) Niels Fischer et al.   NATURE

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites

(2010) Andreas H. Ratje et al.   NATURE

Correlated conformational events in EF-G and the ribosome regulate translocation

(2010) James B Munro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosomal Translocation: One Step Closer to the Molecular Mechanism

(2009) Shinichiro Shoji et al.   ACS Chemical Biology

Mitigating Unwanted Photophysical Processes for Improved Single-Molecule Fluorescence Imaging

(2009) Richa Dave et al.   BIOPHYSICAL JOURNAL

A fast dynamic mode of the EF-G-bound ribosome

(2009) James B Munro et al.   EMBO JOURNAL

Aminoglycoside activity observed on single pre-translocation ribosome complexes

(2009) Michael B Feldman et al.   Nature Chemical Biology

Spontaneous formation of the unlocked state of the ribosome is a multistep process

(2009) J. B. Munro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu

(2009) Xabier Agirrezabala et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Distinct functions of elongation factor G in ribosome recycling and translocation

(2009) A. Savelsbergh et al.   RNA

The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State

(2009) Y.-G. Gao et al.   SCIENCE

Navigating the ribosome's metastable energy landscape

(2009) James B. Munro et al.   TRENDS IN BIOCHEMICAL SCIENCES

Coupling of Ribosomal L1 Stalk and tRNA Dynamics during Translation Elongation

(2008) Jingyi Fei et al.   MOLECULAR CELL

Spontaneous Intersubunit Rotation in Single Ribosomes

(2008) Peter V. Cornish et al.   MOLECULAR CELL

Role of hybrid tRNA-binding states in ribosomal translocation

(2008) S. E. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for hygromycin B inhibition of protein biosynthesis

(2008) M. A. Borovinskaya et al.   RNA

An Oxygen Scavenging System for Improvement of Dye Stability in Single-Molecule Fluorescence Experiments

(2007) Colin Echeverría Aitken et al.   BIOPHYSICAL JOURNAL