Article
Biochemistry & Molecular Biology
Wenqian Li, Daojiong Wang, Yushu Ge, Lei Zhang, Jiang Wu, Dan Liu
Summary: This study presents a novel strategy for discovering CD147 glycosylation inhibitors through computer-aided screening, identifying compound 72 as the best candidate. Experimental results confirmed that compound 72 inhibited MMP production and cancer cell metastasis, and could promote E-cadherin expression by targeting CD147 to inhibit tumor migration. The structures of potential CD147 N-glycosylation inhibitors may guide future optimization efforts.
Article
Oncology
Han-Soo Kim, Ha Jeong Kim, Mi Ra Lee, Ilkyu Han
Summary: The study found that the expression level of EMMPRIN in osteosarcoma is associated with metastasis-free survival, and EMMPRIN plays an important role in osteosarcoma metastasis by regulating the production of MMP and VEGF.
Article
Biochemistry & Molecular Biology
Won Jung Bae, Seokhwi Kim, Ji Mi Ahn, Jae Ho Han, Dakeun Lee
Summary: This study investigated the effect of estrogen on cancer-associated fibroblasts (CAFs) in gastric cancer and found that a subset of CAFs expressed estrogen receptor alpha (ER alpha). Estrogen could induce the expression of ER alpha in CAFs and promote the secretion of a paracrine factor CD147, which significantly enhanced cancer cell migration and invasion. High expression of CD147 was associated with poor prognosis in gastric cancer patients.
Article
Oncology
Xun Gong, Chenglong Zheng, Haiying Jia, Yangruiyu Liu, Rui Yang, Zizhou Chen, Yihang Pan, Xiaowu Li, Yuchen Liu
Summary: This study provides a comprehensive analysis of the expression, mutation, copy number, promoter methylation level changes of LFNG, MFNG, and RFNG in different tumors, along with their prognosis values. High LFNG expression may serve as a poor prognosis molecular marker for PAAD.
Article
Chemistry, Physical
David Teze, Joan Coines, Folmer Fredslund, Kshatresh D. Dubey, Gonzalo N. Bidart, Paul D. Adams, John E. Dueber, Birte Svensson, Carme Rovira, Ditte H. Welner
Summary: The study found that UGT1 from Polygonum tinctorium can catalyze N-, O-, or S-glycosylation with similar rates, and elucidated the molecular basis of N-, O-, and S-specificities using experimental mutagenesis and simulations. It also showed that the active site can be engineered to increase or favor one of the three glycosylation activities over another, leading to the design of more active and specific enzyme variants for glycoside production.
Article
Oncology
Lingling Gao, Xin Nie, Gou Rui, Yue Qi, Juanjuan Liu, Bei Lin
Summary: The study revealed that CD147 and HE4 co-immunoprecipitated and co-located in ovarian cancer tissues and cells, and were associated with disease progression and poor prognosis. HE4 was identified as an independent risk factor for CD147 in ovarian cancer tissues, and ANXA2 was also confirmed as a interacting protein of CD147 in ovarian cancer. Interaction between CD147 and HE4 can affect the invasion and metastasis of ovarian cancer.
Article
Oncology
Shuo Cai, Zhiwei Sun, Ping-Hui Sun, Xiangyu Gao, Ke Ji, Xiuyun Tian, Jiafu Ji, Chunyi Hao, Faris Soliman, Chang Liu, Bilal Al-Sarireh, Paul Griffiths, Stephen Hiscox, Wen G. Jiang, Lin Ye
Summary: The study revealed that reduced expression of Kidins220 was associated with tumorigenesis, metastasis, and overall survival in pancreatic cancer. Knockdown of Kidins220 promoted proliferation, colony formation, and tumorigenic capacity of pancreatic cancer cells, and regulated cell migration through the EGFR/AKT/ERK signaling pathway. Kidins220 also influenced cell invasion via MMP1 in pancreatic cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Plant Sciences
Richard Strasser, Georg Seifert, Monika S. Doblin, Kim L. Johnson, Colin Ruprecht, Fabian Pfrengle, Antony Bacic, Jose M. Estevez
Summary: Glycosylation is a crucial modification process that can alter the biological function of proteins and lipids, affecting the development and physiology of an organism. While challenges remain in understanding plant glycosylation, high throughput approaches may help to address these gaps, revolutionizing the identification and characterization of unknown plant glycosyltransferases and hydrolases.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Jiao Wu, Liang Chen, Chuan Qin, Fei Huo, Xue Liang, Xu Yang, Kui Zhang, Peng Lin, Jiangning Liu, Zhuan Feng, Jiansheng Zhou, Zhuo Pei, Yatao Wang, Xiu-Xuan Sun, Ke Wang, Jiejie Geng, Zhaohui Zheng, Xianghui Fu, Man Liu, Qingyi Wang, Zheng Zhang, Huijie Bian, Ping Zhu, Zhi-Nan Chen
Summary: This study systematically analyzed lung pathogenesis in SARS-CoV-2-infected humanized CD147 transgenic mice and identified CD147 as a crucial regulator for fibroblast activation induced by SARS-CoV-2. The study demonstrated that CD147 plays a significant role in SARS-CoV-2-triggered progressive pulmonary fibrosis and identified it as a potential therapeutic target for treating post-COVID-19 pulmonary fibrosis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Medicine, Research & Experimental
Iolanda Scognamiglio, Lorenza Cocca, Ilaria Puoti, Francesco Palma, Francesco Ingenito, Cristina Quintavalle, Alessandra Affinito, Giuseppina Roscigno, Silvia Nuzzo, Rosario Vincenzo Chianese, Stefania Belli, Guglielmo Thomas, Timo Schomann, Alan Chan, Maria Patrizia Stoppelli, Gerolama Condorelli
Summary: Research has shown that exosomes derived from triple-negative breast cancer cells can activate normal fibroblasts and transform them into cancer-associated fibroblasts, thereby promoting tumor invasion. These findings highlight the significant role of breast cancer cells in remodeling the tumor microenvironment and contributing to tumor evolution.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Biochemistry & Molecular Biology
Martina Duca, Nadia Malagolini, Fabio Dall'Olio
Summary: Glycosylation is a crucial process in the post-synthetic modification of proteins and lipids, while non-coding RNAs play an important role in regulating glycosylation and have reciprocal interactions with it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Paweena Dana, Ryusho Kariya, Worachart Lert-itthiporn, Wunchana Seubwai, Saowaluk Saisomboon, Chaisiri Wongkham, Seiji Okada, Sopit Wongkham, Kulthida Vaeteewoottacharn
Summary: This study focused on the role of CD147 in promoting proinflammatory cytokine production in cholangiocarcinoma (CCA), revealing that CD147-regulated cytokines, such as IL-6, IL-8, and GM-CSF, play a critical role in CCA invasion. The findings suggest that modulation of CD147-related inflammation could be a promising therapeutic strategy for advanced CCA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jung-A Choi, Hyosun Kim, Hyunja Kwon, Elizabeth Hyeji Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: This study examined the clinical value and therapeutic potential of ascitic autotaxin (ATX) in epithelial ovarian cancer (EOC). The results showed that elevated levels of ascitic ATX were associated with advanced stage, high grade, and a short disease-free period in EOC patients. Combining ascitic ATX and serum CA-125 levels improved the diagnostic accuracy for EOC, and functional studies revealed that ascitic ATX played a role in maintaining cancer stem cell-like characteristics and invadopodia formation in EOC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
Reihaneh Alsadat Mahmoudian, Maryam Lotfi Gharaie, Mohammad Reza Abbaszadegan, Ali Alasti, Mohammad Mahdi Forghanifard, Atena Mansouri, Mehran Gholamin
Summary: This study investigated the expression of MMP-13, TWIST1, and CD44 in ESCC and found significant correlations with clinical features, such as tumor progression and invasion. The results suggest that the TWIST1-CD44-MMP-13 axis may be involved in tumor aggressiveness and could serve as diagnostic markers and therapeutic targets in ESCC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Sang Yeol Lee
Summary: Matrix metalloproteinases (MMPs) play crucial roles in cancer metastasis and chronic inflammatory diseases, while ginsenosides have therapeutic potentials. Ginsenosides exhibit anti-metastatic and anti-inflammatory activities by suppressing MMPs through regulation of various signaling pathways.
Review
Oncology
Yiming Li, Juan Tang, Jianli Jiang, Zhinan Chen
Summary: Immunotherapy has achieved significant success in treating cancer, but resistance to this treatment often occurs due to the complex metabolic networks in the tumor microenvironment. Metabolic checkpoints play a crucial role in regulating T cell development, differentiation, and function, as well as coordinating metabolic competition between tumor cells and infiltrating T cells. Thus, targeting metabolic checkpoints may enhance the efficacy of immunotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Chen, Gang Nan, Ding Wei, Ren-You Zhai, Ming Huang, Wu-Wei Yang, Bao-Cai Xing, Xu Zhu, Hai-Feng Xu, Xiao-Dong Wang, Xiao-Yong Zhang, Bao-Rang Zhu, Peng Liu, Guang Cao, Song Gao, Chun-Yi Hao, Ren-Jie Yang, Jian-Hai Guo, Xin Zhang, Kun Gao, Kun Wang, Jian-Feng Wang, Zi-Yu Li, Lin-Zhong Zhu, Rong Ding, Jing Li, Ling Zhao, Yu-Jun Shao, Hai-Chun Liu, Jie-Lai Xia, Ling Wang, Ling-Min Kong, Zhi-Nan Chen, Huijie Bian
Summary: In the adjuvant treatment of unresectable hepatocellular carcinoma, the combination of TACE and I-131-MabThera showed superior antirecurrence efficacy, significantly improved 5-year survival rate of patients, and was well tolerated.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Editorial Material
Cell Biology
Huijie Bian, Ye-Mao Liu, Zhi-Nan Chen
Summary: Two recent studies have found new strategies for ACC targeting in NASH therapy, successfully resolving the unwanted side effects of ACC inhibitors and bringing new hope to NASH treatment.
Review
Neurosciences
Yang Bai, Song Han, Jing-Yu Guan, Jun Lin, Ming-Guang Zhao, Guo-Biao Liang
Summary: The last three decades have seen significant advancements in the use of contralateral C7 nerve transfer in the treatment of upper-extremity paralysis. Surgical techniques have evolved to shorten regeneration distance and achieve direct neurorrhaphy, while research has also explored the role of the brain in functional improvement after CC7 transfer. This review summarizes recent developments in CC7 transfer for both peripheral and central causes of upper-extremity paralysis and discusses the potential of motor cortex stimulation as a rehabilitation treatment.
REVIEWS IN THE NEUROSCIENCES
(2022)
Article
Neurosciences
Dan Ren, Jia-Ni Li, Xin-Tong Qiu, Fa-Ping Wan, Zhen-Yu Wu, Bo-Yuan Fan, Ming-Ming Zhang, Tao Chen, Hui Li, Yang Bai, Yun-Qing Li
Summary: The anterior cingulate cortex (ACC) plays a crucial role in the pathogenesis of abdominal hyperalgesia and anxiety in rats with painful chronic pancreatitis (CP).
NEUROSCIENCE BULLETIN
(2022)
Article
Medicine, General & Internal
Yang Bai, Liang Wen, Yulong Zhao, Jianan Li, Chen Guo, Xiaobin Zhang, Jiaming Yang, Yushu Dong, Litian Ma, Guobiao Liang, Yun Kou, Enxin Wang
Summary: Information about COVID-19 patients with pre-existing COPD is limited. This study aimed to describe the clinical course and outcomes of COVID-19 patients with COPD. The study found that patients with COPD were more likely to experience dyspnea, respiratory failure, and poor clinical outcomes compared to age- and sex-matched patients without COPD. However, laboratory tests did not show more severe infection or inflammation in COPD patients.
Article
Oncology
Ze-Kun Liu, Ke-Fei Wu, Ren-Yu Zhang, Ling-Min Kong, Run-Ze Shang, Jian-Jun Lv, Can Li, Meng Lu, Yu-Le Yong, Cong Zhang, Nai-Shan Zheng, Yan-Hong Li, Zhi-Nan Chen, Huijie Bian, Ding Wei
Summary: In this study, a prognostic signature based on pyroptosis-related lncRNAs in hepatocellular carcinoma (HCC) was constructed, showing significant predictive value for HCC patient prognosis and potential clinical guidance for individualized immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Lian Jingxuan, Ma Litian, Tu Yanyang, Fu Jianfang
Summary: This study investigates the changes and roles of CLC-3 in diabetic encephalopathy, suggesting that CLC-3 may regulate insulin receptor signaling and downstream PI3K/AKT/GSK3 ss signaling pathways, ultimately affecting the pathogenesis of the disease.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Oncology
Hong-Yong Cui, Wei Wei, Mei-Rui Qian, Ruo-Fei Tian, Xin Fu, Hong-Wei Li, Gang Nan, Ting Yang, Peng Lin, Xi Chen, Yu-Meng Zhu, Bin Wang, Xiu-Xuan Sun, Jian-Hua Dou, Jian-Li Jiang, Ling Li, Shi-Jie Wang, Zhi-Nan Chen
Summary: This study identified PDAP1 as a key player in colorectal cancer (CRC) development. PDAP1 overexpression was associated with cell proliferation, migration, invasion, and metastasis in CRC. Inhibiting PDAP1 may be an effective strategy for treating CRC patients with PDAP1 overexpression.
CANCER COMMUNICATIONS
(2022)
Article
Immunology
Li-Tian Ma, Jing-Xuan Lian, Yang Bai, Meng-Juan Shang, Zhe-Zhe Zhang, Fei-Fei Wu, Jing Chen, Xian-Bo Meng, Jin Zheng, Tian Li, Yun-Qing Li, Jing-Jie Wang
Summary: Viral vector technology, especially rAAV, has shown great promise in clinical applications. This study found that intraperitoneal injection of AAV9 can successfully transduce the colonic mucosa and submucosa, and alter the diversity and composition of fecal microbiota in rats.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Lei Gu, Hao Wu, Yang Zhang, Yousheng Wu, Yuan Jin, Tian Li, Litian Ma, Jin Zheng
Summary: This study investigates the effects of ObjectiveElemene emulsion injection (EEI) on the fecal microbiota and metabolites in rats, and finds that different concentrations of EEI have different effects on the microbiota composition.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Neurosciences
Xin-Tong Qiu, Chen Guo, Li-Tian Ma, Xin-Ning Li, Qi-Yan Zhang, Fen-Sheng Huang, Ming-Ming Zhang, Yang Bai, Guo-Biao Liang, Yun-Qing Li
Summary: This study integrated transcriptomic and proteomic data to investigate the molecular correlates of neuropathic pain in the anterior cingulate cortex (ACC). The results identified new pathways associated with NP etiology and highlighted the importance of studying protein-level changes in understanding NP processes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Oncology
Yu-Chen Yang, Can-Jun Zhao, Zhao-Feng Jin, Jin Zheng, Li-Tian Ma
Summary: Lung cancer is a common malignant tumor with a high mortality rate worldwide, especially non-small-cell lung cancer (NSCLC). Current treatment methods, such as radiotherapy, chemotherapy, targeted therapy, and surgery, often face challenges due to drug resistance and tumor invasion or metastasis. The ubiquitin-proteasome pathway (UPP) plays a critical role in tumor occurrence and development. Ubiquitin-specific proteases (USPs), as regulators of UPP, have the potential to be targeted for the treatment of NSCLC. This review focuses on the role of USPs in NSCLC and the potential of targeted drugs, PROTACs, and small-molecule inhibitors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Li-Tian Ma, Yang Bai, Peng Cao, Kai-Xi Ren, Jing Chen, Ting Zhang, Bo-Yuan Fan, Yu Qiao, Hong-Yu Yan, Jing-Jie Wang, Yun-Qing Li, Jin Zheng
Summary: The study evaluated the analgesic effect of β-elemene in neuropathic pain and found that it exerts remarkable analgesic effects by inhibiting spinal astrocytic ERK activation and subsequent neuroinflammatory processes.
