Hyperpolarized13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model

Oxidative Stress Induced by Lipid Peroxidation Is Related with Inflammation of Demyelination and Neurodegeneration in Multiple Sclerosis

(2017) Pin Wang et al.   EUROPEAN NEUROLOGY

Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages

(2016) Caroline Guglielmetti et al.   GLIA

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

(2016) Debbie Le Blon et al.   Journal of Neuroinflammation

Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination

(2016) C. Guglielmetti et al.   NEUROIMAGE

Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis

(2016) Alessandro Didonna et al.   Scientific Reports

The evaluation of MRI diffusion values of active demyelinating lesions in multiple sclerosis

(2016) Mohammad Abdoli et al.   Multiple Sclerosis and Related Disorders

Hyperpolarized 13 C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring

(2016) Myriam M. Chaumeil et al.   NeuroImage-Clinical

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Pro-inflammatory Macrophages Sustain Pyruvate Oxidation through Pyruvate Dehydrogenase for the Synthesis of Itaconate and to Enable Cytokine Expression

(2015) Johannes Meiser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pyruvate Dehydrogenase Kinase 1 Participates in Macrophage Polarization via Regulating Glucose Metabolism

(2015) Zheng Tan et al.   JOURNAL OF IMMUNOLOGY

Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis

(2015) M. K. Jha et al.   JOURNAL OF NEUROSCIENCE

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

(2015) Àlex Rovira et al.   Nature Reviews Neurology

Exploring the origins of grey matter damage in multiple sclerosis

(2015) Massimiliano Calabrese et al.   NATURE REVIEWS NEUROSCIENCE

Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy

(2015) Jasmien Orije et al.   NEUROIMAGE

Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra

(2015) Jelle Praet et al.   NMR IN BIOMEDICINE

Assessing inflammatory liver injury in an acute CCl4model using dynamic 3D metabolic imaging of hyperpolarized [1-13C]pyruvate

(2015) Sonal Josan et al.   NMR IN BIOMEDICINE

Inflammation, Iron, Energy Failure, and Oxidative Stress in the Pathogenesis of Multiple Sclerosis

(2015) Lukas Haider   Oxidative Medicine and Cellular Longevity

Metabolic Reprograming of Mononuclear Phagocytes in Progressive Multiple Sclerosis

(2015) Gillian Margaret Tannahill et al.   Frontiers in Immunology

Analysis of Cancer Metabolism by Imaging Hyperpolarized Nuclei: Prospects for Translation to Clinical Research

(2015) John Kurhanewicz et al.   NEOPLASIA

Hyperpolarized [1-13C] Glutamate: A Metabolic Imaging Biomarker of IDH1 Mutational Status in Glioma

(2014) M. M. Chaumeil et al.   CANCER RESEARCH

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility

(2014) Shuai Zhang et al.   Nutrition & Metabolism

Mapping metabolic changes associated with early Radiation Induced Lung Injury post conformal radiotherapy using hyperpolarized 13C-pyruvate Magnetic Resonance Spectroscopic Imaging

(2014) Kundan Thind et al.   RADIOTHERAPY AND ONCOLOGY

Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models

(2014) Nabeela Nathoo et al.   NeuroImage-Clinical

Metabolic Reprograming in Macrophage Polarization

(2014) Silvia Galván-Peña et al.   Frontiers in Immunology

Chemistry and biochemistry of13C hyperpolarized magnetic resonance using dynamic nuclear polarization

(2013) Kayvan R. Keshari et al.   CHEMICAL SOCIETY REVIEWS

Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum

(2013) Caroline Guglielmetti et al.   NEUROIMAGE

Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination

(2013) Jonathan D. Thiessen et al.   NMR IN BIOMEDICINE

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate

(2013) S. J. Nelson et al.   Science Translational Medicine

Microglia, seen from the CX3CR1 angle

(2013) Yochai Wolf et al.   Frontiers in Cellular Neuroscience

Non-invasive in vivo assessment of IDH1 mutational status in glioma

(2013) Myriam M. Chaumeil et al.   Nature Communications

Magnetic resonance monitoring of lesion evolution in multiple sclerosis

(2013) Àlex Rovira et al.   Therapeutic Advances in Neurological Disorders

Perfusion and vascular permeability: Basic concepts and measurement in DCE-CT and DCE-MRI

(2013) C.A. Cuenod et al.   Diagnostic and Interventional Imaging

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders

(2012) Mithilesh Kumar Jha et al.   Current Neuropharmacology

Multiple sclerosis

(2012) Alyssa Nylander et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Energy failure in multiple sclerosis and its investigation using MR techniques

(2011) David Paling et al.   JOURNAL OF NEUROLOGY

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy

(2011) Kevin M. Brindle et al.   MAGNETIC RESONANCE IN MEDICINE

Characterisation of microglia during de- and remyelination: Can they create a repair promoting environment?

(2011) Elke Verena Voß et al.   NEUROBIOLOGY OF DISEASE

Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma

(2011) Myriam M. Chaumeil et al.   NEUROIMAGE

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Detection of Inflammatory Arthritis by Using Hyperpolarized13C-Pyruvate with MR Imaging and Spectroscopy

(2011) John D. MacKenzie et al.   RADIOLOGY

Noninvasive Detection of Target Modulation following Phosphatidylinositol 3-Kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

(2010) C. S. Ward et al.   CANCER RESEARCH

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Regional differences between grey and white matter in cuprizone induced demyelination

(2009) Viktoria Gudi et al.   BRAIN RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE