Article
Pharmacology & Pharmacy
Mingjun Gao, Jin Yang, Hailong Gong, Yuancai Lin, Jing Liu
Summary: Trametinib has the potential to inhibit glioma cell proliferation, migration, and invasion, induce apoptosis, and target the PKM2/c-myc pathway. The inhibitory effects on glycolytic metabolism may hold promise for the treatment of gliomas.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Weidong Wu, Nanding Yu, Fang Li, Pengqiang Gao, Shiyu Lin, Yong Zhu
Summary: RPL35 plays a crucial role in promoting proliferation and migration of neuroblastoma cells, and its upregulation has been linked to increased aerobic glycolysis. Knockdown of RPL35 decreases HIF1 alpha expression and negatively regulates the ERK pathway, suggesting that the RPL35/ERK/HIF1 alpha axis could be a potential therapeutic target for neuroblastoma.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Qiang Wang, Wei Fan, Bingxue Liang, Bowen Hou, Zaiqun Jiang, Chao Li
Summary: The present study revealed that transcription factor YY1 promotes aerobic glycolysis and cell proliferation in neuroblastoma cells, potentially through direct regulation of LDHA.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Oncology
Simeng Zhang, Zhongyan Hua, Gen Ba, Ning Xu, Jianing Miao, Guifeng Zhao, Wei Gong, Zhihui Liu, Carol J. Thiele, Zhijie Li
Summary: DMAMCL as a single agent decreased cell proliferation in a time- and dose-dependent manner, increased apoptosis in vitro, inhibited tumor growth, and prolonged survival in vivo. It showed synergistic effects when combined with etoposide or cisplatin in vitro, and enhanced antitumor effects when combined with etoposide in vivo. Mechanistically, DMAMCL suppressed aerobic glycolysis by reducing glucose consumption, lactate excretion, ATP production, and PFKL expression.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Jianqun Wang, Xiaojing Wang, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shuang Cai, Boling Yuan, Shikai Jin, Yi Zhou, Qilan Li, Liduan Zheng, Qiangsong Tong
Summary: Salmonella pathogenicity island 1 (SPI1/PU.1), a haematopoietic transcription factor, was found to facilitate glycolytic process, tumourigenesis, invasiveness, and metastasis of colon cancer cells, in association with tumour-associated neutrophils. The delivery of SPI1 mRNA by neutrophils via extracellular vesicles resulted in enhanced SPI1 expression within cancer cells, driving glycolytic gene expression and promoting cancer progression. Therapeutic targeting of SPIB/SPI1-facilitated interplay between cancer cells and neutrophils may suppress aerobic glycolysis and slow cancer progression.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lu Bai, Zhao-Xu Yang, Peng-Fei Ma, Jian-Shan Liu, De-Sheng Wang, Heng-Chao Yu
Summary: SLC25A51 is overexpressed in hepatocellular carcinoma (HCC) and correlates with clinicopathological characteristics and poor survival in HCC patients. Its overexpression promotes the growth and metastasis of HCC cells through reprogramming glucose metabolism.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chenchen Hu, Tianyue Liu, Wenxin Zhang, Yuanjie Sun, Dongbo Jiang, Xiyang Zhang, Yang Liu, Siyi Mao, Yiming Xu, Jingyu Pan, Jing Wang, Yinan Huang, Shuya Yang, Kun Yang
Summary: In this study, it was found that miR-145 negatively correlated with metabolic reprogramming-related genes and inhibited the proliferation and metastasis of cervical cancer cell lines by impeding aerobic glycolysis. The research also showed that miR-145 affected glycolysis through its binding to the 3' UTR of MYC and suppressed tumor growth in mice.
Article
Cell Biology
Qiang Yu, Weiqi Dai, Jie Ji, Liwei Wu, Jiao Feng, Jingjing Li, Yuanyuan Zheng, Yan Li, Ziqi Cheng, Jie Zhang, Jianye Wu, Xuanfu Xu, Chuanyong Guo
Summary: Sodium butyrate (NaBu) inhibits aerobic glycolysis and proliferation, and induces apoptosis in hepatocellular carcinoma (HCC) cells. It downregulates hexokinase 2 (HK2) expression via c-myc signaling, and enhances the anti-HCC effect of sorafenib.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Oncology
Jia Li, Zhi-Qiang Hu, Song-Yang Yu, Li Mao, Zheng-Jun Zhou, Peng-Cheng Wang, Yu Gong, Sheng Su, Jian Zhou, Jia Fan, Shao-Lai Zhou, Xiao-Wu Huang
Summary: This study reveals that circRPN2 can suppress the metastasis of hepatocellular carcinoma by accelerating the degradation of ENO1 and regulating the miR-183-5p/FOXO1 axis to inhibit glycolysis and tumor progression. Additionally, the expression level of circRPN2 can serve as a novel indicator for HCC prognosis.
Article
Chemistry, Multidisciplinary
Xiujuan Zhang, Fei Luo, Shaliu Luo, Ling Li, Xinxin Ren, Jing Lin, Yingchun Liang, Chao Ma, Lihua Ding, Deyu Zhang, Tianxing Ye, Yanni Lin, Bilian Jin, Shan Gao, Qinong Ye
Summary: Aerobic glycolysis, or the Warburg effect, is a critical process in cancer cell growth and metastasis. This study demonstrates that the transcription factor OVOL2 can directly repress glycolytic gene expression to block the Warburg effect. The activation of OVOL2 by the tumor suppressor p53 through inhibiting MDM2-mediated degradation presents a potential avenue for cancer treatment, particularly in breast cancer.
Article
Biochemistry & Molecular Biology
Zhaoyuan Meng, Xueli Bian, Leina Ma, Gang Zhang, Qingxia Ma, Qianqian Xu, Juanjuan Liu, Runze Wang, Jie Lun, Qian Lin, Gaoxiang Zhao, Hongfei Jiang, Wensheng Qiu, Jing Fang, Zhimin Lu
Summary: In this study, it was found that key glycolytic enzyme phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) can interact with SUMO-conjugating enzyme UBC9 and be SUMOylated in glioblastoma cells. Activation of EGFR increases the interaction between UBC9 and PFKFB3, leading to increased SUMOylation and expression of PFKFB3. These findings reveal a previously unknown mechanism underlying the regulation of the Warburg effect through EGFR activation-induced and UBC9-mediated SUMOylation and stabilization of PFKFB3.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Energy & Fuels
Wenchang Yang, Yaxin Wang, Yongzhou Huang, Jiaxian Yu, Tao Wang, Chengguo Li, Lei Yang, Peng Zhang, Liang Shi, Yuping Yin, Kaixiong Tao, Ruidong Li
Summary: Cuproptosis, a new cell death pathway induced by copper, is associated with mitochondrial respiration and mediated by protein lipoylation. This study explores the role of cuproptosis in colorectal cancer progression. The results show that elesclomol-Cu inhibits cell viability and promotes apoptosis in colorectal cancer cells. Additionally, 4-Octyl itaconate (4-OI) enhances cuproptosis and inhibits aerobic glycolysis through GAPDH, leading to better anti-tumor effects in vivo.
Article
Oncology
Yumin Huang, Wei Zhao, Xiaoping Ouyang, Feng Wu, Yujian Tao, Minhua Shi
Summary: The study revealed that the expression of MAOA is downregulated in LUAD and correlates with clinicopathologic features, serving as an independent biomarker. Overexpression of MAOA inhibits LUAD cell proliferation and suppresses aerobic glycolysis by decreasing HK2. This suggests that the MAOA/HK2 axis could be potential targets in LUAD therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Monika Sakowicz-Burkiewicz, Tadeusz Pawelczyk, Marlena Zysk
Summary: Neuroblastoma is a common childhood cancer with a significant risk of death. Recent studies have shown that extracellular vesicles play a crucial role in promoting tumorigenesis by carrying metabolic enzymes that influence energy metabolism. Glycolysis has been identified as playing a primary role in energy metabolism in neuroblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yanbo Zhu, Fang Li, Yilong Wan, Hansi Liang, Si Li, Bo Peng, Liqun Shao, Yunyun Xu, Dong Jiang
Summary: MiR-620 inhibits ESCC malignancy and suppresses aerobic glycolysis in ESCC cells by targeting FOXM1 and HER2. Exosomal miR-620 is highly secreted in ESCC and can regulate aerobic glycolysis in HFL1 cells via the FOXM1/HER2 signaling pathway. Additionally, exosomal miR-620 can promote ESCC metastasis by reprogramming aerobic glycolysis in lung fibroblasts.
FRONTIERS IN ONCOLOGY
(2022)