Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation

Endothelial Akt1 loss promotes prostate cancer metastasis via β-catenin-regulated tight-junction protein turnover

(2018) Fei Gao et al.   BRITISH JOURNAL OF CANCER

CXCR2 promotes breast cancer metastasis and chemoresistance via suppression of AKT1 and activation of COX2

(2018) Han Xu et al.   CANCER LETTERS

Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway

(2018) Linlin Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Knockdown of mediator subunit Med19 suppresses bladder cancer cell proliferation and migration by downregulating Wnt/β-catenin signalling pathway

(2017) Hejia Yuan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

β-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model

(2017) Bui Tung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer

(2017) Kirstine Jacobsen et al.   Nature Communications

Combined inhibition of AKT and HSF1 suppresses breast cancer stem cells and tumor growth

(2017) Richard L. Carpenter et al.   Oncotarget

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins

(2017) Marina Riggio et al.   Scientific Reports

Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations

(2017) Guanhua Rao et al.   Scientific Reports

AKT in cancer: new molecular insights and advances in drug development

(2016) Prabhjot S. Mundi et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Differentiation therapy of hepatocellular carcinoma by inhibiting the activity of AKT/GSK-3β/β-catenin axis and TGF-β induced EMT with sophocarpine

(2016) Ping-Ping Zhang et al.   CANCER LETTERS

AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

(2016) Chia-Wei Li et al.   CANCER RESEARCH

Phase I Study of an AKT Inhibitor (MK-2206) Combined with Lapatinib in Adult Solid Tumors Followed by Dose Expansion in Advanced HER2+ Breast Cancer

(2016) K. B. Wisinski et al.   CLINICAL CANCER RESEARCH

High basal Wnt signaling is further induced by PI3K/mTor inhibition but sensitive to cSRC inhibition in mammary carcinoma cell lines with HER2/3 overexpression

(2015) Elpetra P. M. Timmermans-Sprang et al.   BMC CANCER

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis

(2015) Lisa M. Ooms et al.   CANCER CELL

Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy

(2015) Elias E. Stratikopoulos et al.   CANCER CELL

Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6

(2015) YONG WEON YI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

JRK is a positive regulator of β-catenin transcriptional activity commonly overexpressed in colon, breast and ovarian cancer

(2015) L Pangon et al.   ONCOGENE

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor

(2015) Huey-En Tzeng et al.   Oncotarget

The prognostic value of phosphorylated Akt in breast cancer: a systematic review

(2015) Zu-Yao Yang et al.   Scientific Reports

Transmembrane-Bound IL-15–Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3β/β-Catenin Pathway

(2015) Huaqin Yuan et al.   NEOPLASIA

PIKfyve, MTMR3 and their product PtdIns5Pregulate cancer cell migration and invasion through activation of Rac1

(2014) Angela Oppelt et al.   BIOCHEMICAL JOURNAL

Akt1 and Akt3 Exert Opposing Roles in the Regulation of Vascular Tumor Growth

(2014) T. L. Phung et al.   CANCER RESEARCH

Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells

(2013) Yong Weon Yi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Distinct roles of Akt1 in regulating proliferation, migration and invasion in HepG2 and HCT 116 cells

(2013) LIANG CHEN et al.   ONCOLOGY REPORTS

Role of epidermal growth factor receptor in breast cancer

(2012) Hiroko Masuda et al.   BREAST CANCER RESEARCH AND TREATMENT

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

(2012) Reetta Virtakoivu et al.   MOLECULAR BIOLOGY OF THE CELL

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

(2012) S. N. Zolov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Akt1 deficiency delays tumor progression, vascular invasion and distant metastasis in a murine model of thyroid cancer

(2011) M Saji et al.   ONCOGENE

Akt isoform-specific signaling in breast cancer

(2011) Y. Rebecca Chin et al.   Cell Adhesion & Migration

A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5Pand other phosphoinositides

(2010) Deborah Sarkes et al.   BIOCHEMICAL JOURNAL

Epidermal Growth Factor Receptor in Triple-Negative and Basal-Like Breast Cancer

(2010) Monika L. Burness et al.   CANCER JOURNAL

Epidermal growth factor receptor regulates β-catenin location, stability, and transcriptional activity in oral cancer

(2010) Chien-Hsing Lee et al.   Molecular Cancer

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

(2009) O. K. Mirzoeva et al.   CANCER RESEARCH

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE