Targeting the Hippo Pathway for Breast Cancer Therapy

Statins: a role in breast cancer therapy?

(2018) S. Borgquist et al.   JOURNAL OF INTERNAL MEDICINE

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

(2018) T. Azad et al.   Nature Communications

The Hippo Pathway: Immunity and Cancer

(2018) Zaid Taha et al.   Cancers

Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors

(2018) et al.   Cancers

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

(2018) Francesca Zanconato et al.   NATURE MEDICINE

TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells

(2018) Dana Elster et al.   Nature Communications

Regulation of the Hippo Pathway by Phosphatidic Acid-Mediated Lipid-Protein Interaction

(2018) Han Han et al.   MOLECULAR CELL

Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM)

(2017) M.J. Duffy et al.   EUROPEAN JOURNAL OF CANCER

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

(2017) Adrian Britschgi et al.   NATURE

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ

(2017) Deanna N. Edwards et al.   Science Signaling

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

(2016) Toshiro Moroishi et al.   CELL

Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies

(2016) Min Hwan Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

(2016) Ballachanda N Devaiah et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer

(2016) Gabriel N. Hortobagyi et al.   NEW ENGLAND JOURNAL OF MEDICINE

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

(2016) Y Wang et al.   ONCOGENE

Targeting the Hippo pathway: Clinical implications and therapeutics

(2016) Shuai Ye et al.   PHARMACOLOGICAL RESEARCH

Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network

(2016) Shuguo Sun et al.   TRENDS IN CELL BIOLOGY

Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors

(2016) A. Patnaik et al.   Cancer Discovery

BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin

(2016) Ballachanda N Devaiah et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations

(2016) Albino Troilo et al.   Oncotarget

Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015

(2015) A. S. Coates et al.   ANNALS OF ONCOLOGY

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Abstract 4444: Small molecule drug Verteporfin inhibits TAZ/YAP-driven signaling and tumorigenicity of breast cancer cells

(2015) Han Sun et al.   CANCER RESEARCH

Opposing roles of conventional and novel PKC isoforms in Hippo-YAP pathway regulation

(2015) Rui Gong et al.   CELL RESEARCH

FDA Approval: Palbociclib for the Treatment of Postmenopausal Patients with Estrogen Receptor-Positive, HER2-Negative Metastatic Breast Cancer

(2015) J. A. Beaver et al.   CLINICAL CANCER RESEARCH

Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer

(2015) J. Diaz-Martin et al.   ENDOCRINE-RELATED CANCER

The Hippo transducers TAZ and YAP in breast cancer: oncogenic activities and clinical implications

(2015) Marcello Maugeri-Saccà et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides

(2015) Zheng Zhou et al.   FASEB JOURNAL

A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells

(2015) Cheng Chang et al.   GENES & DEVELOPMENT

Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors

(2015) Chun-Han Lin et al.   MOLECULAR BIOLOGY OF THE CELL

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

(2015) Huabing Zhang et al.   Science Signaling

Regulation of sensitivity of tumor cells to antitubulin drugs by Cdk1-TAZ signalling

(2015) Yulei Zhao et al.   Oncotarget

Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins

(2015) Wenqi Wang et al.   Cell Reports

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

(2015) Huabing Zhang et al.   Science Signaling

Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers

(2015) Yusuke Oku et al.   FEBS Open Bio

The Hippo transducer TAZ as a biomarker of pathological complete response in HER2-positive breast cancer patients treated with trastuzumab-based neoadjuvant therapy

(2015) Patrizia Vici et al.   Oncotarget

Molecular profiling and computational network analysis of TAZ-mediated mammary tumorigenesis identifies actionable therapeutic targets

(2015) Costa Frangou et al.   Oncotarget

Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype

(2015) Lisha Xiang et al.   Oncotarget

Hippo pathway in mammary gland development and breast cancer

(2014) P. Shi et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

YAP-Induced Resistance of Cancer Cells to Antitubulin Drugs Is Modulated by a Hippo-Independent Pathway

(2014) Y. Zhao et al.   CANCER RESEARCH

Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

(2014) X. Hong et al.   EMBO JOURNAL

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation

(2014) Jianhua Huang et al.   JOURNAL OF CELL BIOLOGY

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

(2014) M Bartucci et al.   ONCOGENE

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

Ado-trastuzumab emtansine (T-DM1): a novel antibody-drug conjugate for the treatment of HER2-positive metastatic breast cancer

(2014) Jessica M Baron et al.   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Auranofin, an Anti-Rheumatic Gold Compound, Modulates Apoptosis by Elevating the Intracellular Calcium Concentration ([Ca2+]i) in MCF-7 Breast Cancer Cells

(2014) Elizabeth Varghese et al.   Cancers

BMP4 is a novel transcriptional target and mediator of mammary cell migration downstream of the Hippo pathway component TAZ

(2013) Dulcie Lai et al.   CELLULAR SIGNALLING

Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer

(2013) Paola Bendinelli et al.   EUROPEAN JOURNAL OF CANCER

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Actin-binding and Cell Proliferation Activities of Angiomotin Family Members Are Regulated by Hippo Pathway-mediated Phosphorylation

(2013) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic significance of mammalian sterile 20-like kinase 1 in breast cancer

(2013) Xiaoyan Lin et al.   TUMOR BIOLOGY

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

(2013) Isabel Serrano et al.   Nature Communications

Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer

(2013) Eva J. Vlug et al.   CELLULAR ONCOLOGY

The Ets Transcription Factor GABP Is a Component of the Hippo Pathway Essential for Growth and Antioxidant Defense

(2013) Hongtan Wu et al.   Cell Reports

YAP Promotes Breast Cell Proliferation and Survival Partially through Stabilizing the KLF5 Transcription Factor

(2012) Xu Zhi et al.   AMERICAN JOURNAL OF PATHOLOGY

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

(2012) Y. Liu-Chittenden et al.   GENES & DEVELOPMENT

The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain

(2012) J. M. Lamar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hippo signaling pathway and stem cell biology

(2012) Azucena Ramos et al.   TRENDS IN CELL BIOLOGY

TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer

(2012) Alejandra Bruna et al.   Nature Communications

Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2011) S. Aebi et al.   ANNALS OF ONCOLOGY

Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011

(2011) A. Goldhirsch et al.   ANNALS OF ONCOLOGY

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF

(2011) D. Lai et al.   CANCER RESEARCH

TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis

(2011) Dong Zhao et al.   CARCINOGENESIS

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

LATS1 tumor suppressor is a novel actin-binding protein and negative regulator of actin polymerization

(2011) Stacy Visser-Grieve et al.   CELL RESEARCH

Dasatinib as a Single Agent in Triple-Negative Breast Cancer: Results of an Open-Label Phase 2 Study

(2011) R. S. Finn et al.   CLINICAL CANCER RESEARCH

Exemestane for Breast-Cancer Prevention in Postmenopausal Women

(2011) Paul E. Goss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Excellent outcomes with adjuvant toremifene or tamoxifen in early stage breast cancer

(2010) Jaime D. Lewis et al.   CANCER

LATS tumor suppressor: A new governor of cellular homeostasis

(2010) Stacy Visser et al.   CELL CYCLE

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

The Hippo Pathway Regulates Wnt/β-Catenin Signaling

(2010) Xaralabos Varelas et al.   DEVELOPMENTAL CELL

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCPE3 Ligase

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP1 Cooperates with ASPP2 to Dephosphorylate and Activate TAZ

(2010) Chen-Ying Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neratinib, an Irreversible ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced ErbB2-Positive Breast Cancer

(2010) Harold J. Burstein et al.   JOURNAL OF CLINICAL ONCOLOGY

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma

(2010) M Z Xu et al.   ONCOGENE

c-Abl phosphorylation of ΔNp63α is critical for cell viability

(2010) M Yuan et al.   Cell Death & Disease

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis

(2010) V Tomlinson et al.   Cell Death & Disease

Semisynthetic Latrunculin Derivatives as Inhibitors of Metastatic Breast Cancer: Biological Evaluations, Preliminary Structure-Activity Relationship and Molecular Modeling Studies

(2009) Mohammad A. Khanfar et al.   ChemMedChem

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

(2009) Joel S. Parker et al.   JOURNAL OF CLINICAL ONCOLOGY

The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals

(2008) Qi Zeng et al.   CANCER CELL

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

(2008) S. W. Chan et al.   CANCER RESEARCH

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

NDR Kinase Is Activated by RASSF1A/MST1 in Response to Fas Receptor Stimulation and Promotes Apoptosis

(2008) Anton Vichalkovski et al.   CURRENT BIOLOGY

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Latrunculin A and Its C-17-O-Carbamates Inhibit Prostate Tumor Cell Invasion and HIF-1 Activation in Breast Tumor Cells⊥

(2008) Khalid A. El Sayed et al.   JOURNAL OF NATURAL PRODUCTS

The Hippo Pathway Promotes Notch Signaling in Regulation of Cell Differentiation, Proliferation, and Oocyte Polarity

(2008) Jianzhong Yu et al.   PLoS One