HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

From instruction to output: Wnt/PCP signaling in development and cancer

(2018) Ashley Ceinwen Humphries et al.   CURRENT OPINION IN CELL BIOLOGY

Wnt signalling: conquering complexity

(2018) Katrin E. Wiese et al.   DEVELOPMENT

Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles

(2018) Thomas Tu et al.   JOURNAL OF VIROLOGY

Recapitulation of hepatitis B virus–host interactions in liver organoids from human induced pluripotent stem cells

(2018) Yun-Zhong Nie et al.   EBioMedicine

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes

(2017) Florian A. Lempp et al.   HEPATOLOGY

Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions

(2017) Yuchen Xia et al.   JOURNAL OF HEPATOLOGY

Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Mohsen Naghavi et al.   LANCET

A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms

(2017) A. S. Khazali et al.   Stem Cell Reviews and Reports

A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms

(2017) A. S. Khazali et al.   Stem Cell Reviews and Reports

Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

(2017) Fuminori Sakurai et al.   Scientific Reports

Activation of signal transduction pathways during hepatic oncogenesis

(2016) Waihong Chung et al.   CANCER LETTERS

HBx mutations promote hepatoma cell migration through the Wnt/β-catenin signaling pathway

(2016) Zhen Chen et al.   CANCER SCIENCE

Genetic polymorphisms in the Wnt/β-catenin pathway genes as predictors of tumor development and survival in patients with hepatitis B virus-associated hepatocellular carcinoma

(2016) Soon Sun Kim et al.   CLINICAL BIOCHEMISTRY

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor

(2016) Florian A. Lempp et al.   JOURNAL OF HEPATOLOGY

Experimental in vitro and in vivo models for the study of human hepatitis B virus infection

(2016) Lena Allweiss et al.   JOURNAL OF HEPATOLOGY

Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor

(2016) Adrien Decorsière et al.   NATURE

Targeting Wnt/β-catenin pathway in hepatocellular carcinoma treatment

(2016) Valery Vilchez   WORLD JOURNAL OF GASTROENTEROLOGY

Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus

(2016) Shun Kaneko et al.   Scientific Reports

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

(2016) Sathidpak Nantasanti et al.   Stem Cells Translational Medicine

Frizzled7: A Promising Achilles’ Heel for Targeting the Wnt Receptor Complex to Treat Cancer

(2016) Toby Phesse et al.   Cancers

Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation

(2015) Stefan Koch et al.   CELL

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

A developmental framework for induced pluripotency

(2015) Kazutoshi Takahashi et al.   DEVELOPMENT

Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactionsin vitro

(2015) Dustin R. Berger et al.   HEPATOLOGY

New physiologically-relevant liver tissue model based on hierarchically cocultured primary rat hepatocytes with liver endothelial cells

(2015) Wenjin Xiao et al.   Integrative Biology

Estimating the global prevalence of hepatitis B

(2015) Jennifer H MacLachlan et al.   LANCET

Hepatic progenitor cells of biliary origin with liver repopulation capacity

(2015) Wei-Yu Lu et al.   NATURE CELL BIOLOGY

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

(2015) Han-Jin Park et al.   PLoS One

Pluripotent stem cell-derived hepatocyte-like cells

(2014) R.E. Schwartz et al.   BIOTECHNOLOGY ADVANCES

HBV life cycle is restricted in mouse hepatocytes expressing human NTCP

(2014) Hanjie Li et al.   Cellular & Molecular Immunology

C-terminal-truncated hepatitis B virus X protein enhances the development of diethylnitrosamine-induced hepatocellular carcinogenesis

(2014) I. Quetier et al.   JOURNAL OF GENERAL VIROLOGY

Strategies for immortalization of primary hepatocytes

(2014) Eva Ramboer et al.   JOURNAL OF HEPATOLOGY

Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems

(2014) A. Shlomai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line

(2014) Darong Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly of Human Organs from Stem Cells to Study Liver Disease

(2013) Kan Handa et al.   AMERICAN JOURNAL OF PATHOLOGY

Human Induced Pluripotent Stem Cells in Hepatology

(2013) Sabine Gerbal-Chaloin et al.   AMERICAN JOURNAL OF PATHOLOGY

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

(2013) A. Dash et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

Discovery of naturally occurring transmissible chronic hepatitis B virus infection among Macaca fascicularis from mauritius island

(2013) Tatiana Dupinay et al.   HEPATOLOGY

Molecular Determinants of Hepatitis B and D Virus Entry Restriction in Mouse Sodium Taurocholate Cotransporting Polypeptide

(2013) H. Yan et al.   JOURNAL OF VIROLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Identification of small molecules for human hepatocyte expansion and iPS differentiation

(2013) Jing Shan et al.   Nature Chemical Biology

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Adult-Derived Human Liver Progenitor Cells in Long-Term Culture Maintain Appropriate Gatekeeper Mechanisms against Transformation

(2012) Isabelle Scheers et al.   CELL TRANSPLANTATION

Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy

(2012) Ching-Lung Lai et al.   HEPATOLOGY

Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies

(2012) Yue Yu et al.   Stem Cell Research

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

Metastatic Progression of Prostate Cancer and E-Cadherin

(2011) Aaron P. Putzke et al.   AMERICAN JOURNAL OF PATHOLOGY

The Amelioration of AH by Abstinence and the Attenuation of Oxidative Stress

(2011) Tianyi Wang et al.   HEPATO-GASTROENTEROLOGY

Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells

(2011) Yuki Ohi et al.   NATURE CELL BIOLOGY

Isolation of Primary Human Hepatocytes from Normal and Diseased Liver Tissue: A One Hundred Liver Experience

(2011) Ricky H. Bhogal et al.   PLoS One

Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

(2011) J.-P. Gillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment of functional telomerase immortalized human hepatocytes and a hepatic stellate cell line for telomere-targeting anticancer drug development

(2010) Koji Waki et al.   CANCER SCIENCE

The Lower Serum Immunoglobulin G2 Level in Severe Cases than in Mild Cases of Pandemic H1N1 2009 Influenza Is Associated with Cytokine Dysregulation

(2010) Jasper Fuk-Woo Chan et al.   Clinical and Vaccine Immunology

When pathways collide: collaboration and connivance among signalling proteins in development

(2010) Helen McNeill et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad

(2010) Kari Nichole Nejak-Bowen et al.   SEMINARS IN CANCER BIOLOGY

Tumors Originating from Induced Pluripotent Stem Cells and Methods for Their Prevention

(2009) Dirk Duinsbergen et al.   Annals of the New York Academy of Sciences

Subcellular Mislocalization of Mutant Hepatitis B X Proteins Contributes to Modulation of STAT/SOCS Signaling in Hepatocellular Carcinoma

(2009) C.-Thomas Bock et al.   INTERVIROLOGY

Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro

(2009) Elsa Genové et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melioidosis and Aboriginal seasons in northern Australia

(2009) Allen C. Cheng et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Dysregulation of hepatocyte cell cycle and cell viability by hepatitis B virus

(2009) Ruth Chin et al.   VIRUS RESEARCH

Isolation of Primary Human Hepatocytes After Partial Hepatectomy: Criteria for Identification of the Most Promising Liver Specimen

(2008) Florian Wolfgang Rudolf Vondran et al.   ARTIFICIAL ORGANS

Senescence and immortality in hepatocellular carcinoma

(2008) Mehmet Ozturk et al.   CANCER LETTERS

The IκB kinase – a bridge between inflammation and cancer

(2008) Michael Karin   CELL RESEARCH

c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts

(2008) Marius Wernig et al.   Cell Stem Cell

Establishment of Immortalized Human Hepatocytes by Introduction of HPV16 E6/E7 and hTERT as Cell Sources for Liver Cell-Based Therapy

(2008) Yosuke Tsuruga et al.   CELL TRANSPLANTATION

The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression

(2008) Elizabeth Vincan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Molecular targeted therapies in hepatocellular carcinoma

(2008) Josep M. Llovet et al.   HEPATOLOGY

Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells

(2008) Miran Kim et al.   JOURNAL OF HEPATOLOGY

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

(2008) K. Okita et al.   SCIENCE