Hepatitis B Virus DNA Integration Occurs Early in the Viral Life Cycle in an In Vitro Infection Model via Sodium Taurocholate Cotransporting Polypeptide-Dependent Uptake of Enveloped Virus Particles

Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivo

(2017) Lena Allweiss et al.   GUT

Identification of an Intermediate in Hepatitis B Virus Covalently Closed Circular (CCC) DNA Formation and Sensitive and Selective CCC DNA Detection

(2017) Jun Luo et al.   JOURNAL OF VIROLOGY

RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg

(2017) Christine I. Wooddell et al.   Science Translational Medicine

HBV DNA Integration: Molecular Mechanisms and Clinical Implications

(2017) Thomas Tu et al.   Viruses-Basel

Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma

(2017) R Chauhan et al.   Oncogenesis

HDV RNA replication is associated with HBV repression and interferon-stimulated genes induction in super-infected hepatocytes

(2016) Dulce Alfaiate et al.   ANTIVIRAL RESEARCH

Antiviral activity of various interferons and pro-inflammatory cytokines in non-transformed cultured hepatocytes infected with hepatitis B virus

(2016) Nathalie Isorce et al.   ANTIVIRAL RESEARCH

A Slow Maturation Process Renders Hepatitis B Virus Infectious

(2016) Stefan Seitz et al.   Cell Host & Microbe

HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant

(2016) William S. Mason et al.   GASTROENTEROLOGY

Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor

(2016) Florian A. Lempp et al.   JOURNAL OF HEPATOLOGY

Intracellular transport and egress of hepatitis B virus

(2016) Marie-Lise Blondot et al.   JOURNAL OF HEPATOLOGY

The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013

(2016) Jeffrey D Stanaway et al.   LANCET

Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes

(2016) Anirban Chakraborty et al.   Nature Communications

Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

(2016) Ling-Hao Zhao et al.   Nature Communications

Serum viral duplex-linear DNA proportion increases with the progression of liver disease in patients infected with HBV

(2015) Xing-Liang Zhao et al.   GUT

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B

(2015) Michael Nassal   GUT

Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma

(2015) Hongli Yan et al.   HEPATOLOGY

Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection

(2015) T. Tu et al.   JOURNAL OF VIRAL HEPATITIS

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression

(2014) Chi-Chiu Lau et al.   CANCER CELL

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

(2014) Hind Ghezraoui et al.   MOLECULAR CELL

Transcript-RNA-templated DNA recombination and repair

(2014) Havva Keskin et al.   NATURE

Explanted Diseased Livers – A Possible Source of Metabolic Competent Primary Human Hepatocytes

(2014) Moritz Kleine et al.   PLoS One

Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly

(2013) Guoyi Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

(2012) Tassilo Volz et al.   JOURNAL OF HEPATOLOGY

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

(2012) Akihiro Fujimoto et al.   NATURE GENETICS

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

(2012) Wing-Kin Sung et al.   NATURE GENETICS

GenBank

(2012) Dennis A. Benson et al.   NUCLEIC ACIDS RESEARCH

Recurrent Targeted Genes of Hepatitis B Virus in the Liver Cancer Genomes Identified by a Next-Generation Sequencing–Based Approach

(2012) Dong Ding et al.   PLoS Genetics

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells

(2011) Zhiyong Mao et al.   CELL CYCLE

Hepatocyte polarization is essential for the productive entry of the hepatitis B virus

(2011) Andreas Schulze et al.   HEPATOLOGY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Clonal Expansion of Normal-Appearing Human Hepatocytes during Chronic Hepatitis B Virus Infection

(2010) W. S. Mason et al.   JOURNAL OF VIROLOGY

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Efficiency of carcinogenesis: Is the mutator phenotype inevitable?

(2010) Robert A. Beckman   SEMINARS IN CANCER BIOLOGY

Circos: An information aesthetic for comparative genomics

(2009) M. Krzywinski et al.   GENOME RESEARCH

Clearance of hepatitis B surface antigen and risk of hepatocellular carcinoma in a cohort chronically infected with hepatitis B virus

(2009) Josephine Simonetti et al.   HEPATOLOGY

Detection of Clonally Expanded Hepatocytes in Chimpanzees with Chronic Hepatitis B Virus Infection

(2009) W. S. Mason et al.   JOURNAL OF VIROLOGY

Fine Mapping of Pre-S Sequence Requirements for Hepatitis B Virus Large Envelope Protein-Mediated Receptor Interaction

(2009) A. Schulze et al.   JOURNAL OF VIROLOGY

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells

(2008) O. Hantz et al.   JOURNAL OF GENERAL VIROLOGY

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS