Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Critical differences in toxicity mechanisms in induced pluripotent stem cell-derived hepatocytes, hepatic cell lines and primary hepatocytes

(2014) Anna-Karin M. Sjogren et al.   ARCHIVES OF TOXICOLOGY

Genetic and epigenetic regulation of gene expression in fetal and adult human livers

(2014) Marc Bonder et al.   BMC GENOMICS

Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture

(2014) Richard L. Gieseck III et al.   PLoS One

Histone Deacetylase Inhibitor Valproic Acid Promotes the Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-Like Cells

(2014) Yuki Kondo et al.   PLoS One

Lineage-Specific Regulation of Epigenetic Modifier Genes in Human Liver and Brain

(2014) Matthias K. Weng et al.   PLoS One

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

(2014) Kazuo Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pluripotent Stem Cell–Derived Hepatocytes: Potential and Challenges in Pharmacology

(2013) Dagmara Szkolnicka et al.   Annual Review of Pharmacology and Toxicology

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Production of hepatocyte-like cells from human pluripotent stem cells

(2013) Nicholas R F Hannan et al.   Nature Protocols

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Coordinate Regulation of DNA Methylation and H3K27me3 in Mouse Embryonic Stem Cells

(2013) James A. Hagarman et al.   PLoS One

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

(2013) Clay W Scott et al.   TOXICOLOGY LETTERS

DNA methylation dynamics in the hepatic CYP3A4 gene promoter

(2012) Marina Kacevska et al.   BIOCHIMIE

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

(2012) Kazuo Takayama et al.   BIOMATERIALS

Transcriptional ontogeny of the developing liver

(2012) Janice S Lee et al.   BMC GENOMICS

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

(2012) Richard Kia et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Perspectives on Epigenetics and Its Relevance to Adverse Drug Reactions

(2011) M Kacevska et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung

(2011) Xavier Tekpli et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatic Xenobiotic Metabolizing Enzyme and Transporter Gene Expression through the Life Stages of the Mouse

(2011) Janice S. Lee et al.   PLoS One

Evaluation of 28 Human Embryonic Stem Cell Lines for Use as Unrelated Donors in Stem Cell Therapy: Implications of HLA and ABO Genotypes

(2010) Jeoung Eun Lee et al.   CELL TRANSPLANTATION

Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection

(2010) Hirotaka Kawakami et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Role of Epigenetic Mechanisms in Differential Regulation of the Dioxin-Inducible Human CYP1A1 and CYP1B1 Genes

(2010) S. R. Beedanagari et al.   MOLECULAR PHARMACOLOGY

Analysis of humanCYP1A1andCYP1A2genes and their shared bidirectional promoter in eight world populations

(2009) Lucia F. Jorge-Nebert et al.   HUMAN MUTATION

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

(2009) Roza Ghotbi et al.   PHARMACOGENOMICS JOURNAL

Stem cell-derived hepatocytes and their use in toxicology

(2009) Christiane Guguen-Guillouzo et al.   TOXICOLOGY

Epigenetic Regulation of Genes Encoding Drug-Metabolizing Enzymes and Transporters; DNA Methylation and Other Mechanisms

(2008) Ichiro Ieiri et al.   CURRENT DRUG METABOLISM

Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice

(2008) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes

(2008) Hesham Basma et al.   GASTROENTEROLOGY

QUMA: quantification tool for methylation analysis

(2008) Y. Kumaki et al.   NUCLEIC ACIDS RESEARCH