Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect

Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products

(2010) Michael Haack et al.   BIOLOGICAL CHEMISTRY

Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA

(2010) Tiziana Squillaro et al.   FASEB JOURNAL

Impact of histone deacetylase inhibitors SAHA and MS-275 on DNA repair pathways in human mesenchymal stem cells

(2010) Giovanni Di Bernardo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin

(2010) Ahmad Faizal Abdull Razis et al.   LUNG CANCER

Electrophilic tuning of the chemoprotective natural product sulforaphane

(2010) Y.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers

(2009) Natalya Hanlon et al.   CANCER LETTERS

Antioxidant and pro-oxidant capacities of ITCs

(2009) Luca Valgimigli et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Oncogene-Induced Senescence Does Not Require the p16INK4a or p14ARF Melanoma Tumor Suppressors

(2009) Sebastian Haferkamp et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention

(2009) Emily Ho et al.   JOURNAL OF NUTRITION

Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS

(2008) Tatyana A. Klimova et al.   FASEB JOURNAL

Covalent Binding to Tubulin by Isothiocyanates

(2008) Lixin Mi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interferon-γ induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells

(2008) Kwang Seok Kim et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hormetic Dietary Phytochemicals

(2008) Tae Gen Son et al.   NEUROMOLECULAR MEDICINE

Histone Deacetylase Inhibitors Promote Apoptosis and Senescence in Human Mesenchymal Stem Cells

(2008) Giovanni Di Bernardo et al.   STEM CELLS AND DEVELOPMENT