- Home
- Publications
- Publication Search
- Publication Details
Title
Leukocyte Heparanase: A Double-Edged Sword in Tumor Progression
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2019-04-29
DOI
10.3389/fonc.2019.00331
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours
- (2018) Keith Dredge et al. BRITISH JOURNAL OF CANCER
- Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury
- (2018) Valentina Masola et al. FASEB JOURNAL
- The Immune Landscape of Cancer
- (2018) Vésteinn Thorsson et al. IMMUNITY
- Molecular principles for heparin oligosaccharide-based inhibition of neutrophil elastase in cystic fibrosis
- (2018) Apparao B. Kummarapurugu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Early low-anticoagulant desulfated heparin after traumatic brain injury
- (2018) Katsuhiro Nagata et al. Journal of Trauma and Acute Care Surgery
- Early low-anticoagulant desulfated heparin after traumatic brain injury
- (2018) Katsuhiro Nagata et al. Journal of Trauma and Acute Care Surgery
- Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors
- (2018) Edward Hammond et al. Journal for ImmunoTherapy of Cancer
- Heparan Sulfate Mimetics in Cancer Therapy: The Challenge to Define Structural Determinants and the Relevance of Targets for Optimal Activity
- (2018) Cinzia Lanzi et al. MOLECULES
- NK cell heparanase controls tumor invasion and immune surveillance
- (2017) Eva M. Putz et al. JOURNAL OF CLINICAL INVESTIGATION
- Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats
- (2017) Benjarat Changyaleket et al. Journal of Neuroinflammation
- Macrophages as Key Drivers of Cancer Progression and Metastasis
- (2017) Sebastian R. Nielsen et al. MEDIATORS OF INFLAMMATION
- BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
- (2017) Kimberly Mayes et al. Oncotarget
- Heparanase and macrophage interplay in the onset of liver fibrosis
- (2017) Maria Francesca Secchi et al. Scientific Reports
- The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression
- (2017) Preeti Singh et al. NEOPLASIA
- The Role of Heparanase in the Pathogenesis of Acute Pancreatitis: A Potential Therapeutic Target
- (2017) Iyad Khamaysi et al. Scientific Reports
- Overexpression of heparanase enhances T lymphocyte activities and intensifies the inflammatory response in a model of murine rheumatoid arthritis
- (2017) Andreas Digre et al. Scientific Reports
- Heparanase augments inflammatory chemokine production from colorectal carcinoma cell lines
- (2016) Naoki Tsunekawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Dendritic Cell-Based Immunotherapy: State of the Art and Beyond
- (2016) K. F. Bol et al. CLINICAL CANCER RESEARCH
- Heparanase: From basic research to therapeutic applications in cancer and inflammation
- (2016) Israel Vlodavsky et al. DRUG RESISTANCE UPDATES
- Mechanisms of heparanase inhibitors in cancer therapy
- (2016) Benjamin Heyman et al. EXPERIMENTAL HEMATOLOGY
- An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches
- (2016) Mayumi Sue et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Heparanase Promotes Glioma Progression and Is Inversely Correlated with Patient Survival
- (2016) Soumi Kundu et al. MOLECULAR CANCER RESEARCH
- Heparanase-neutralizing antibodies attenuate lymphoma tumor growth and metastasis
- (2016) Marina Weissmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heparanase is required for activation and function of macrophages
- (2016) Lilach Gutter-Kapon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects
- (2016) Shengmeng Di et al. Science China-Life Sciences
- Heparanase and cancer progression: New directions, new promises
- (2016) Gil Arvatz et al. Human Vaccines & Immunotherapeutics
- PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples
- (2015) Boris Winterhoff et al. EUROPEAN JOURNAL OF CANCER
- Regulation of natural cytotoxicity receptors by heparan sulfate proteoglycans in -cis : A lesson from NKp44
- (2015) Michael Brusilovsky et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Heparanase of murine effector lymphocytes and neutrophils is not required for their diapedesis into sites of inflammation
- (2015) Liat Stoler-Barak et al. FASEB JOURNAL
- Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation
- (2015) Todd V. Brennan et al. JOURNAL OF CLINICAL INVESTIGATION
- Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes
- (2015) Ignazio Caruana et al. NATURE MEDICINE
- The Profile of Heparanase Expression Distinguishes Differentiated Thyroid Carcinoma from Benign Neoplasms
- (2015) Leandro Luongo Matos et al. PLoS One
- Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression
- (2015) Bo Tang et al. Oncotarget
- The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine
- (2015) Deok-Beom Jung et al. Oncotarget
- Tumor cell secretion of soluble factor(s) for specific immunosuppression
- (2015) Arihiro Kano Scientific Reports
- HLA-A2–Restricted Cytotoxic T Lymphocyte Epitopes from Human Heparanase as Novel Targets for Broad-Spectrum Tumor Immunotherapy
- (2015) Ting Chen et al. NEOPLASIA
- Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium
- (2014) Rebecca Lever et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- 2-O, 3-O-Desulfated Heparin Inhibits Neutrophil Elastase–Induced HMGB-1 Secretion and Airway Inflammation
- (2014) Kathryn L. Griffin et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Heparanase expression and localization in different types of human lung cancer
- (2014) Teresa Cristina Fernandes dos Santos et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Mice deficient in heparanase exhibit impaired dendritic cell migration and reduced airway inflammation
- (2014) Ivan K. H. Poon et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Tumor-Associated Macrophages: From Mechanisms to Therapy
- (2014) Roy Noy et al. IMMUNITY
- Macrophage Polarization in Pancreatic Carcinoma: Role of Heparanase Enzyme
- (2014) Esther Hermano et al. JNCI-Journal of the National Cancer Institute
- Soluble Heparan Sulfate Fragments Generated by Heparanase Trigger the Release of Pro-Inflammatory Cytokines through TLR-4
- (2014) Katharine J. Goodall et al. PLoS One
- Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia
- (2014) M. L. Davila et al. Science Translational Medicine
- Adjuvant heparanase inhibitor PI-88 therapy for hepatocellular carcinoma recurrence
- (2014) Chun-Jen Liu WORLD JOURNAL OF GASTROENTEROLOGY
- Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
- (2014) Guillermo Arango Duque et al. Frontiers in Immunology
- The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics
- (2014) Edward Hammond et al. Frontiers in Oncology
- The Function of Heparanase in Diabetes and its Complications
- (2013) Fang Wang et al. Canadian Journal of Diabetes
- Heparanase in inflammation and inflammation-associated cancer
- (2013) Amichay Meirovitz et al. FEBS Journal
- Partially-desulfated heparin improves survival inPseudomonaspneumonia by enhancing bacterial clearance and ameliorating lung injury
- (2013) Lokesh Sharma et al. Journal of Immunotoxicology
- The metastasis-promoting roles of tumor-associated immune cells
- (2013) Heath A. Smith et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Involvement of heparanase in atherosclerosis and other vessel wall pathologies
- (2013) Israel Vlodavsky et al. MATRIX BIOLOGY
- Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation
- (2013) C.R. Parish et al. MATRIX BIOLOGY
- Versatile role of heparanase in inflammation
- (2013) Rachel Goldberg et al. MATRIX BIOLOGY
- PG545, an Angiogenesis and Heparanase Inhibitor, Reduces Primary Tumor Growth and Metastasis in Experimental Pancreatic Cancer
- (2013) K. T. Ostapoff et al. MOLECULAR CANCER THERAPEUTICS
- Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues
- (2013) Edward Hammond et al. FEBS Open Bio
- Heparanase and Autoimmune Diabetes
- (2013) Charmaine J. Simeonovic et al. Frontiers in Immunology
- Cancer and Innate Immune System Interactions
- (2012) Yanan Liu et al. JOURNAL OF IMMUNOTHERAPY
- Molecular characterization, expression profiles of the porcine SDC2 and HSPG2 genes and their association with hematologic parameters
- (2012) Weimin Wang et al. MOLECULAR BIOLOGY REPORTS
- Multiple Antigenic Peptides Based on H-2Kb-Restricted CTL Epitopes from Murine Heparanase Induce a Potent Antitumor Immune Response In Vivo
- (2012) X.-D. Tang et al. MOLECULAR CANCER THERAPEUTICS
- The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis
- (2012) Eric P Schmidt et al. NATURE MEDICINE
- PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma Model
- (2012) Edward Hammond et al. PLoS One
- PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models
- (2011) K Dredge et al. BRITISH JOURNAL OF CANCER
- Multiple Antigenic Peptides of Human Heparanase Elicit a Much More Potent Immune Response against Tumors
- (2011) G.-Z. Wang et al. Cancer Prevention Research
- Heparanase Is Highly Expressed and Regulates Proliferation in GH-Secreting Pituitary Tumor Cells
- (2011) Hadara Rubinfeld et al. ENDOCRINOLOGY
- Tumor-infiltrating immune cells and prognosis: the potential link between conventional cancer therapy and immunity
- (2011) Caroline Jochems et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Heparanase Induces Signal Transducer and Activator of Transcription (STAT) Protein Phosphorylation
- (2011) Victoria Cohen-Kaplan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice
- (2011) Immanuel Lerner et al. JOURNAL OF CLINICAL INVESTIGATION
- Engineering Dendritic Cells to Enhance Cancer Immunotherapy
- (2011) Jeanette E Boudreau et al. MOLECULAR THERAPY
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
- (2011) M. Kalos et al. Science Translational Medicine
- Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands
- (2010) Narayanam V. Rao et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Cytotoxic T lymphocyte epitopes from human heparanase can elicit a potent anti-tumor immune response in mice
- (2010) Xu-Dong Tang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer
- (2010) Roy M. Bremnes et al. Journal of Thoracic Oncology
- Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis
- (2010) Menachem Bitan et al. MOLECULAR IMMUNOLOGY
- The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy
- (2009) K. Dredge et al. INVESTIGATIONAL NEW DRUGS
- Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage
- (2009) Chun-Jen Liu et al. JOURNAL OF HEPATOLOGY
- Heparanase expression by Barrett's epithelium and during esophageal carcinoma progression
- (2009) Rita Brun et al. MODERN PATHOLOGY
- A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy
- (2009) Y Watanabe et al. ONCOGENE
- H-2Kb-Restricted CTL Epitopes from Mouse Heparanase Elicit an Antitumor Immune Response In vivo
- (2008) X.-D. Tang et al. CANCER RESEARCH
- Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies
- (2008) Noriko Komatsu et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Heparanase Facilitates Cell Adhesion and Spreading by Clustering of Cell Surface Heparan Sulfate Proteoglycans
- (2008) Flonia Levy-Adam et al. PLoS One
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation