PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

Heparin/heparan sulphate-based drugs

(2010) Neha S. Gandhi et al.   DRUG DISCOVERY TODAY

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis

(2010) Uri Barash et al.   FEBS Journal

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

(2010) Ken D. Johnstone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited

(2009) Sonja Loges et al.   CANCER CELL

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Preclinical Drug Development Must Consider the Impact on Metastasis

(2009) P. S. Steeg et al.   CLINICAL CANCER RESEARCH

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage

(2009) Chun-Jen Liu et al.   JOURNAL OF HEPATOLOGY

Expression and clinical significance of heparanase in neuroblastoma

(2009) Li-Duan Zheng et al.   World Journal of Pediatrics

Expression of Heparanase in Renal Cell Carcinomas: Implications for Tumor Invasion and Prognosis

(2008) S. Mikami et al.   CLINICAL CANCER RESEARCH

Expression of Heparanase in Hepatocellular Carcinoma Has Prognostic Significance: A Tissue Microarray Study

(2008) Gang Chen et al.   ONCOLOGY RESEARCH