Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues

Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis

(2012) Vito Ferro et al.   JOURNAL OF MEDICINAL CHEMISTRY

PG545, a Heparan Sulfate Mimetic, Reduces Heparanase Expression In Vivo, Blocks Spontaneous Metastases and Enhances Overall Survival in the 4T1 Breast Carcinoma Model

(2012) Edward Hammond et al.   PLoS One

Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids

(2011) Nicolas Sapay et al.   BIOPOLYMERS

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models

(2011) K Dredge et al.   BRITISH JOURNAL OF CANCER

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-d-glucuronidase (heparanase)

(2011) Neha S Gandhi et al.   GLYCOBIOLOGY

Rethinking the metastatic cascade as a therapeutic target

(2011) Lida A. Mina et al.   Nature Reviews Clinical Oncology

M402, a Novel Heparan Sulfate Mimetic, Targets Multiple Pathways Implicated in Tumor Progression and Metastasis

(2011) He Zhou et al.   PLoS One

Inhibition kinetics of catabolic dehydrogenases by elevated moieties of ATP and ADP - implication for a new regulation mechanism in Lactococcus lactis

(2010) Rong Cao et al.   FEBS Journal

Unraveling the Specificity of Heparanase Utilizing Synthetic Substrates

(2010) Sherket B. Peterson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening

(2009) Edward Hammond et al.   ANALYTICAL BIOCHEMISTRY

The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy

(2009) K. Dredge et al.   INVESTIGATIONAL NEW DRUGS

Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage

(2009) Chun-Jen Liu et al.   JOURNAL OF HEPATOLOGY

Heparanase: One Molecule with Multiple Functions in Cancer Progression

(2008) Israel Vlodavsky et al.   CONNECTIVE TISSUE RESEARCH

Synthesis and heparanase inhibitory activity of sulfated mannooligosaccharides related to the antiangiogenic agent PI-88

(2007) Jon K. Fairweather et al.   BIOORGANIC & MEDICINAL CHEMISTRY